Skip to content
Use your HSA or FSA funds

Gene

DNASE1L3

deoxyribonuclease 1L3

Summary

Cytogenetic location
3p14.3
Coordinates
Chromosome 3: 58,192,257–58,210,972 (GRCh38)
Exons
8 exons across 18.7 kb
Protein
305 amino acids
Also known as
DNAS1L3, LSD, D3
MANE Select transcript
ENST00000394549.7NM_004944.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Autoimmune Disease

    • A disorder resulting from loss of function or tissue destruction of an organ or multiple organs, arising from humoral or cellular immune responses of the individual to their own tissue constituents. It may be systemic (e.g., systemic lupus erythematosus), or organ specific, (e.g., thyroiditis).

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong

  • Systemic Lupus Erythematosus

    • An autoimmune multi-organ disease typically associated with vasculopathy and autoantibody production. Most patients have antinuclear antibodies (ANA). The presence of anti-dsDNA or anti-Smith antibodies are highly-specific.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Standard SLE: hydroxychloroquine, mycophenolate, belimumab, anifrolumab; Complement-deficient lupus: FFP replacement; Interferonopathy: anifrolumab, JAK inhibitors; All: sun protection, cardiovascular risk management, pregnancy planning

How DNASE1L3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where DNASE1L3 sits. DNASE1L3 and 11 genes near it on chromosome 3, from 57,701,615 to 58,701,614.Chromosome 33p14.3p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q2957.8 Mb58 Mb58.2 Mb58.4 Mb58.6 MbSLMAP: 57,755,450–57,931,461, forward strandSLMAPFLNB: 58,008,398–58,172,251, forward strandFLNBDNASE1L3: 58,192,257–58,210,972, reverse strandDNASE1L3ABHD6: 58,237,502–58,296,814, forward strandABHD6RPP14: 58,306,239–58,324,695, forward strandRPP14HTD2: 58,306,239–58,324,695, forward strandHTD2PXK: 58,332,579–58,426,867, forward strandPXKPDHB: 58,425,143–58,434,012, reverse strandPDHBKCTD6: 58,491,078–58,502,584, forward strandKCTD6ACOX2: 58,504,544–58,537,400, reverse strandACOX2FAM107A: 58,564,114–58,627,651, reverse strandFAM107AFAM3D: 58,633,941–58,666,877, reverse strandFAM3DDiagram of DNASE1L3: 8 exons on the reverse strand of chromosome 3Exon 8: 1 known disease-causing siteExon 6: 2 known disease-causing sitesExon 5: 2 known disease-causing sitesExon 3: 2 known disease-causing sitesExon 2: 1 known disease-causing siteExon 8: 58,192,257–58,192,803, 547 basesExon 7: 58,193,343–58,193,439, 97 basesExon 6: 58,197,821–58,197,978, 158 basesExon 5: 58,200,997–58,201,109, 113 basesExon 4: 58,204,769–58,204,881, 113 basesExon 3: 58,205,471–58,205,560, 90 basesExon 2: 58,208,218–58,208,306, 89 basesExon 1: 58,210,766–58,210,972, 207 bases876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.4 kb of the gene's 18.7 kb; 918 of those bases code for the protein.

How a genome test reads DNASE1L3

8

positions in DNASE1L3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 18.7 kb of DNASE1L3, introns included, not only the 1.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DNASE1L3 gene: deoxyribonuclease 1L3. Retrieved 17 October 2026, from https://dantelabs.com/genes/dnase1l3

Vancouver

Dante Labs. DNASE1L3 gene: deoxyribonuclease 1L3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/dnase1l3

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test