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Gene

WDR4

WDR4 tRNA N7-guanosine methyltransferase non-catalytic subunit

Summary

Cytogenetic location
21q22.3
Coordinates
Chromosome 21: 42,849,226–42,879,539 (GRCh38)
Exons
11 exons across 30.3 kb
Protein
412 amino acids
Also known as
TRM82, TRMT82, Wuho
MANE Select transcript
ENST00000398208.3NM_018669.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads WDR4 yet. The test sequences your whole genome, so your data includes it all the same.

How WDR4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 21, with a bracket where WDR4 sits. WDR4 and 12 genes near it on chromosome 21, from 42,364,383 to 43,364,382.Chromosome 2121q22.3p13p12p11.2p11.1q11.1q11.2q21.1q21.2q21.3q22.11q22.12q22.13q22.2q22.342.4 Mb42.6 Mb42.8 Mb43 Mb43.2 MbTFF1: 42,362,282–42,366,541, reverse strandTFF1TMPRSS3: 42,371,840–42,396,122, reverse strandTMPRSS3UBASH3A: 42,403,447–42,447,684, forward strandUBASH3ARSPH1: 42,472,486–42,496,366, reverse strandRSPH1SLC37A1: 42,495,994–42,581,440, forward strandSLC37A1PDE9A: 42,653,584–42,776,512, forward strandPDE9AWDR4: 42,849,226–42,879,539, reverse strandWDR4NDUFV3: 42,879,644–42,913,304, forward strandNDUFV3ERVH48-1: 42,916,803–42,925,630, reverse strandERVH48-1PKNOX1: 42,974,328–43,034,494, forward strandPKNOX1CBS: 43,050,900–43,076,943, reverse strandCBSU2AF1: 43,092,956–43,107,605, reverse strandU2AF1CRYAA: 43,169,008–43,172,810, forward strandCRYAADiagram of WDR4: 11 exons on the reverse strand of chromosome 21Exon 5: 1 known disease-causing siteExon 1: 1 known disease-causing siteExon 11: 42,849,226–42,850,242, 1,017 basesExon 10: 42,852,255–42,852,324, 70 basesExon 9: 42,853,569–42,853,752, 184 basesExon 8: 42,854,562–42,854,626, 65 basesExon 7: 42,855,682–42,855,780, 99 basesExon 6: 42,859,662–42,859,722, 61 basesExon 5: 42,862,282–42,862,394, 113 basesExon 4: 42,863,440–42,863,596, 157 basesExon 3: 42,873,551–42,873,691, 141 basesExon 2: 42,876,702–42,876,767, 66 basesExon 1: 42,879,407–42,879,539, 133 bases11109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.1 kb of the gene's 30.3 kb; 1,239 of those bases code for the protein.

How a genome test reads WDR4

5

positions in WDR4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 30.3 kb of WDR4, introns included, not only the 2.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). WDR4 gene: WDR4 tRNA N7-guanosine methyltransferase non-catalytic subunit. Retrieved 17 October 2026, from https://dantelabs.com/genes/wdr4

Vancouver

Dante Labs. WDR4 gene: WDR4 tRNA N7-guanosine methyltransferase non-catalytic subunit [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/wdr4

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