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Gene

REN

renin

Summary

Cytogenetic location
1q32.1
Coordinates
Chromosome 1: 204,154,819–204,166,337 (GRCh38)
Exons
10 exons across 11.5 kb
Protein
406 amino acids
MANE Select transcript
ENST00000272190.9NM_000537.4
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

  • Autosomal Dominant Tubulointerstitial Kidney Disease

    • Familial Juvenile Hyperuricemic NephropathyAutosomal dominant

      A dominantly inherited tubulointerstitial kidney disease, most often caused by UMOD variants (and also REN or SEC61A1), with high uric acid, early gout and gradual loss of kidney function.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong
      Actionability

      Knowing supports kidney function monitoring, gout treatment and careful evaluation of related living kidney donors; the REN form may respond to fludrocortisone.

  • Renal Tubular Dysgenesis

    • Autosomal recessive

      A recessive disorder of the renin-angiotensin system caused by variants in REN, AGT, ACE or AGTR1, leading to absent urine production before birth and usually fatal in the newborn period.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong
      Actionability

      Carrier status can inform reproductive planning for couples.

How REN is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where REN sits. REN and 15 genes near it on chromosome 1, from 203,660,578 to 204,660,577.Chromosome 11q32.1p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44203.8 Mb204 Mb204.2 Mb204.4 Mb204.6 MbATP2B4: 203,626,664–203,744,081, forward strandATP2B4LAX1: 203,765,169–203,778,175, forward strandLAX1ZC3H11A: 203,795,562–203,854,999, forward strandZC3H11AZBED6: 203,795,623–203,854,999, forward strandZBED6: 203,802,094–203,802,192, forward strandSNRPE: 203,861,496–203,871,152, forward strandSNRPESOX13: 204,073,106–204,127,744, forward strandSOX13ETNK2: 204,131,062–204,152,184, reverse strandETNK2REN: 204,154,819–204,166,337, reverse strandRENKISS1: 204,190,337–204,196,638, reverse strandKISS1GOLT1A: 204,198,157–204,214,121, reverse strandGOLT1APLEKHA6: 204,218,851–204,378,391, reverse strandPLEKHA6PPP1R15B: 204,396,492–204,411,887, reverse strandPPP1R15BPIK3C2B: 204,421,803–204,494,858, reverse strandPIK3C2BMDM4: 204,516,369–204,558,120, forward strandMDM4LRRN2: 204,617,170–204,685,745, reverse strandLRRN2Diagram of REN: 10 exons on the reverse strand of chromosome 1Exon 10: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 2: 2 known disease-causing sitesExon 1: 5 known disease-causing sitesExon 10: 204,154,819–204,155,177, 359 basesExon 9: 204,155,820–204,155,918, 99 basesExon 8: 204,156,178–204,156,319, 142 basesExon 7: 204,156,677–204,156,796, 120 basesExon 6: 204,157,361–204,157,369, 9 basesExon 5: 204,159,399–204,159,595, 197 basesExon 4: 204,160,560–204,160,678, 119 basesExon 3: 204,161,292–204,161,415, 124 basesExon 2: 204,162,013–204,162,163, 151 basesExon 1: 204,166,196–204,166,337, 142 bases109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.5 kb of the gene's 11.5 kb; 1,221 of those bases code for the protein.

Sequencing REN

10

positions in REN where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 11.5 kb of REN, introns included, not only the 1.5 kb of exons.

Genes linked to the same conditions

Traits linked to REN

The Human Phenotype Ontology lists these as features of the rare conditions REN can cause. Each trait's page lists the other genes linked to it.

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-17: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). REN gene: renin. Retrieved 17 October 2026, from https://dantelabs.com/genes/ren

Vancouver

Dante Labs. REN gene: renin [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ren

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