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Gene

SLC7A7

solute carrier family 7 member 7

Summary

Cytogenetic location
14q11.2
Coordinates
Chromosome 14: 22,773,222–22,815,435 (GRCh38)
Exons
10 exons across 42.2 kb
Protein
511 amino acids
Inheritance
Autosomal recessive
Also known as
y+LAT-1, Y+LAT1
Previous symbols
LPI
MANE Select transcript
ENST00000674313.1NM_003982.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Urea Cycle Disorder

    • Lysinuric Protein IntoleranceAutosomal recessive

      Caused by variants in SLC7A7, which impair transport of lysine, arginine and ornithine and can cause high ammonia after protein-rich meals, poor growth, lung and kidney complications.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing allows protein restriction and citrulline supplementation, managed like a urea cycle disorder, with monitoring of lungs and kidneys.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How SLC7A7 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 14, with a bracket where SLC7A7 sits. SLC7A7 and 24 genes near it on chromosome 14, from 22,294,329 to 23,294,328.Chromosome 1414q11.2p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.11q32.12q32.13q32.2q32.31q32.32q32.3322.4 Mb22.6 Mb22.8 Mb23 Mb23.2 MbDAD1: 22,564,902–22,589,245, reverse strandDAD1ABHD4: 22,598,243–22,612,963, forward strandABHD4OR6J1: 22,630,929–22,644,352, reverse strandOR6J1OXA1L: 22,766,522–22,776,355, forward strandOXA1LSLC7A7: 22,773,222–22,815,435, reverse strandSLC7A7MRPL52: 22,829,871–22,836,024, forward strandMRPL52MMP14: 22,836,532–22,849,041, forward strandMMP14LRP10: 22,871,709–22,881,713, forward strandLRP10REM2: 22,883,136–22,887,686, forward strandREM2RBM23: 22,893,204–22,919,182, reverse strandRBM23PRMT5: 22,920,108–22,929,458, reverse strandPRMT5HAUS4: 22,946,228–22,957,161, reverse strandHAUS4: 22,946,270–22,982,258, reverse strandAJUBA: 22,971,177–22,982,647, reverse strandAJUBAC14orf93: 22,985,894–23,010,529, reverse strandC14orf93PSMB5: 23,016,540–23,035,239, reverse strandPSMB5PSMB11: 23,042,212–23,044,060, forward strandPSMB11CDH24: 23,047,062–23,057,668, reverse strandCDH24ACIN1: 23,058,561–23,095,614, reverse strandACIN1C14orf119: 23,094,692–23,100,456, forward strandC14orf119CIROP: 23,099,062–23,105,018, reverse strandCIROPCEBPE: 23,117,036–23,120,256, reverse strandCEBPESLC7A8: 23,125,295–23,183,683, reverse strandSLC7A8RNF212B: 23,185,316–23,273,477, forward strandRNF212BHOMEZ: 23,258,697–23,299,796, reverse strandHOMEZDiagram of SLC7A7: 10 exons on the reverse strand of chromosome 14Exon 10: 2 known disease-causing sitesExon 9: 19 known disease-causing sitesExon 8: 13 known disease-causing sitesExon 7: 5 known disease-causing sitesExon 6: 8 known disease-causing sitesExon 5: 3 known disease-causing sitesExon 4: 12 known disease-causing sitesExon 3: 12 known disease-causing sitesExon 2: 40 known disease-causing sitesExon 10: 22,773,222–22,773,716, 495 basesExon 9: 22,773,933–22,774,116, 184 basesExon 8: 22,774,354–22,774,503, 150 basesExon 7: 22,775,444–22,775,540, 97 basesExon 6: 22,775,833–22,775,936, 104 basesExon 5: 22,776,195–22,776,318, 124 basesExon 4: 22,778,793–22,778,937, 145 basesExon 3: 22,779,926–22,780,051, 126 basesExon 2: 22,812,900–22,813,440, 541 basesExon 1: 22,815,320–22,815,435, 116 bases10864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.1 kb of the gene's 42.2 kb; 1,536 of those bases code for the protein.

How a genome test reads SLC7A7

130

positions in SLC7A7 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 42.2 kb of SLC7A7, introns included, not only the 2.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SLC7A7 gene: solute carrier family 7 member 7. Retrieved 16 October 2026, from https://dantelabs.com/genes/slc7a7

Vancouver

Dante Labs. SLC7A7 gene: solute carrier family 7 member 7 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/slc7a7

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