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Gene

VPS33B

VPS33B late endosome and lysosome associated

Summary

Cytogenetic location
15q26.1
Coordinates
Chromosome 15: 90,998,673–91,022,594 (GRCh38)
Exons
23 exons across 23.9 kb
Protein
617 amino acids
Also known as
FLJ14848
MANE Select transcript
ENST00000333371.8NM_018668.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads VPS33B yet. The test sequences your whole genome, so your data includes it all the same.

How VPS33B is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 15, with a bracket where VPS33B sits. VPS33B and 11 genes near it on chromosome 15, from 90,510,634 to 91,510,633.Chromosome 1515q26.1p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q14q15.1q15.2q15.3q21.1q21.2q21.3q22.1q22.2q22.31q22.32q22.33q23q24.1q24.2q24.3q25.1q25.2q25.3q26.1q26.2q26.390.6 Mb90.8 Mb91 Mb91.2 Mb91.4 MbCRTC3: 90,529,881–90,645,345, forward strandCRTC3BLM: 90,717,340–90,816,166, forward strandBLMFURIN: 90,868,588–90,883,564, forward strandFURINFES: 90,883,695–90,896,371, forward strandFESMAN2A2: 90,902,218–90,922,585, forward strandMAN2A2HDDC3: 90,911,796–90,935,196, reverse strandHDDC3UNC45A: 90,930,180–90,954,093, forward strandUNC45ARCCD1: 90,954,825–90,964,809, forward strandRCCD1PRC1: 90,966,038–90,995,629, reverse strandPRC1: 90,966,190–91,022,566, reverse strandVPS33B: 90,998,673–91,022,594, reverse strandVPS33BSV2B: 91,099,700–91,302,565, forward strandSV2BDiagram of VPS33B: 23 exons on the reverse strand of chromosome 15Exon 22: 2 known disease-causing sitesExon 21: 2 known disease-causing sitesExon 20: 5 known disease-causing sitesExon 18: 3 known disease-causing sitesExon 17: 3 known disease-causing sitesExon 9: 1 known disease-causing siteExon 8: 2 known disease-causing sitesExon 7: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 5: 3 known disease-causing sitesExon 4: 2 known disease-causing sitesExon 2: 2 known disease-causing sitesExon 1: 3 known disease-causing sitesExon 23: 90,998,673–90,999,054, 382 basesExon 22: 90,999,677–90,999,793, 117 basesExon 21: 90,999,900–90,999,975, 76 basesExon 20: 91,000,490–91,000,591, 102 basesExon 19: 91,001,389–91,001,462, 74 basesExon 18: 91,002,050–91,002,182, 133 basesExon 17: 91,003,085–91,003,131, 47 basesExon 16: 91,004,877–91,004,931, 55 basesExon 15: 91,005,055–91,005,119, 65 basesExon 14: 91,005,380–91,005,454, 75 basesExon 13: 91,005,694–91,005,784, 91 basesExon 12: 91,005,973–91,006,059, 87 basesExon 11: 91,006,372–91,006,445, 74 basesExon 10: 91,006,652–91,006,729, 78 basesExon 9: 91,006,950–91,007,046, 97 basesExon 8: 91,007,469–91,007,573, 105 basesExon 7: 91,007,870–91,007,964, 95 basesExon 6: 91,009,801–91,009,846, 46 basesExon 5: 91,013,804–91,013,871, 68 basesExon 4: 91,014,384–91,014,433, 50 basesExon 3: 91,016,963–91,017,024, 62 basesExon 2: 91,017,805–91,017,885, 81 basesExon 1: 91,022,154–91,022,594, 441 bases23201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.5 kb of the gene's 23.9 kb; 1,854 of those bases code for the protein.

How a genome test reads VPS33B

44

positions in VPS33B where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 23.9 kb of VPS33B, introns included, not only the 2.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). VPS33B gene: VPS33B late endosome and lysosome associated. Retrieved 16 October 2026, from https://dantelabs.com/genes/vps33b

Vancouver

Dante Labs. VPS33B gene: VPS33B late endosome and lysosome associated [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/vps33b

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