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Gene

DNASE1

deoxyribonuclease 1

Summary

Cytogenetic location
16p13.3
Coordinates
Chromosome 16: 3,654,691–3,658,095 (GRCh38)
Exons
9 exons across 3.4 kb
Protein
282 amino acids
Previous symbols
DNL1
MANE Select transcript
ENST00000246949.10NM_005223.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads DNASE1 yet. The test sequences your whole genome, so your data includes it all the same.

How DNASE1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 16, with a bracket where DNASE1 sits. DNASE1 and 19 genes near it on chromosome 16, from 3,156,393 to 4,156,392.Chromosome 1616p13.3p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.33.2 Mb3.4 Mb3.6 Mb3.8 Mb4 MbOR1F1: 3,188,204–3,224,779, forward strandOR1F1ZNF200: 3,222,324–3,236,221, reverse strandZNF200MEFV: 3,240,392–3,256,954, reverse strandMEFVZNF263: 3,263,800–3,301,705, forward strandZNF263TIGD7: 3,298,390–3,305,729, reverse strandTIGD7ZNF75A: 3,305,385–3,320,003, forward strandZNF75AOR2C1: 3,355,889–3,357,306, forward strandOR2C1: 3,365,099–3,479,550, forward strandZSCAN32: 3,382,081–3,401,483, reverse strandZSCAN32ZNF174: 3,401,194–3,409,478, forward strandZNF174ZNF597: 3,432,414–3,443,539, reverse strandZNF597NAA60: 3,443,623–3,486,961, forward strandNAA60C16orf90: 3,493,484–3,495,489, reverse strandC16orf90IFT38: 3,500,976–3,540,653, forward strandIFT38NLRC3: 3,538,090–3,577,403, reverse strandNLRC3SLX4: 3,579,654–3,611,617, reverse strandSLX4TRAP1: 3,651,639–3,717,595, reverse strandTRAP1DNASE1: 3,654,691–3,658,095, forward strandDNASE1CREBBP: 3,725,054–3,880,734, reverse strandCREBBPADCY9: 3,953,387–4,116,493, reverse strandADCY9Diagram of DNASE1: 9 exons on the forward strand of chromosome 16Exon 2: 1 known disease-causing siteExon 1: 3,654,691–3,655,044, 354 basesExon 2: 3,655,373–3,655,520, 148 basesExon 3: 3,655,849–3,655,937, 89 basesExon 4: 3,656,102–3,656,185, 84 basesExon 5: 3,656,638–3,656,753, 116 basesExon 6: 3,656,999–3,657,111, 113 basesExon 7: 3,657,187–3,657,341, 155 basesExon 8: 3,657,720–3,657,816, 97 basesExon 9: 3,657,906–3,658,095, 190 bases1234567895′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.3 kb of the gene's 3.4 kb; 849 of those bases code for the protein.

How a genome test reads DNASE1

1

position in DNASE1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 3.4 kb of DNASE1, introns included, not only the 1.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DNASE1 gene: deoxyribonuclease 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/dnase1

Vancouver

Dante Labs. DNASE1 gene: deoxyribonuclease 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/dnase1

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