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Gene

IL10

interleukin 10

Summary

Cytogenetic location
1q32.1
Coordinates
Chromosome 1: 206,767,602–206,772,494 (GRCh38)
Exons
5 exons across 4.9 kb
Protein
178 amino acids
Also known as
CSIF, TGIF, IL10A, IL-10
MANE Select transcript
ENST00000423557.1NM_000572.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Inflammatory Bowel Diseases (IBD)

    • Inflammatory Bowel Disease

      A spectrum of small and large bowel inflammatory diseases of unknown etiology. It includes Crohn's disease, ulcerative colitis, and colitis of indeterminate type.

      • ClinGen rates the link moderate
      • 1 GenCC submitter rates it definitive or strong

Broader groupings

  • Other Inborn Errors of Immunity

    • Inborn error of immunity

      One of 114 genes linked to it

      Inherited disorders of the immune system caused by changes in single genes, affecting how the body fights infection or regulates inflammation.

      • ClinGen rates the link moderate
      • 1 GenCC submitter rates it definitive or strong

How IL10 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 1, with a bracket where IL10 sits. IL10 and 17 genes near it on chromosome 1, from 206,270,048 to 207,270,047.Chromosome 11q32.1p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44206.4 Mb206.6 Mb206.8 Mb207 Mb207.2 MbSRGAP2: 206,203,346–206,464,436, forward strandSRGAP2IKBKE: 206,470,332–206,498,687, forward strandIKBKERASSF5: 206,507,521–206,603,589, forward strandRASSF5EIF2D: 206,571,292–206,612,556, reverse strandEIF2DDYRK3: 206,635,518–206,684,419, forward strandDYRK3MAPKAPK2: 206,684,871–206,734,284, forward strandMAPKAPK2IL10: 206,767,602–206,772,494, reverse strandIL10IL19: 206,770,764–206,842,981, forward strandIL19IL20: 206,865,621–206,869,223, forward strandIL20IL24: 206,897,443–206,904,139, forward strandIL24FCMR: 206,903,267–206,923,247, reverse strandFCMRPIGR: 206,928,522–206,949,367, reverse strandPIGRFCAMR: 206,957,965–206,970,625, reverse strandFCAMRC1orf116: 207,018,050–207,032,821, reverse strandC1orf116PFKFB2: 207,034,366–207,081,243, forward strandPFKFB2YOD1: 207,043,849–207,052,980, reverse strandYOD1C4BPB: 207,088,802–207,100,001, forward strandC4BPBC4BPA: 207,102,319–207,145,047, forward strandC4BPADiagram of IL10: 5 exons on the reverse strand of chromosome 1Exon 5: 206,767,602–206,768,728, 1,127 basesExon 4: 206,769,829–206,769,894, 66 basesExon 3: 206,770,907–206,771,059, 153 basesExon 2: 206,771,356–206,771,415, 60 basesExon 1: 206,772,271–206,772,494, 224 bases543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.6 kb of the gene's 4.9 kb; 537 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). IL10 gene: interleukin 10. Retrieved 16 October 2026, from https://dantelabs.com/genes/il10

Vancouver

Dante Labs. IL10 gene: interleukin 10 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/il10

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