Gene
MT-TW
mitochondrially encoded tRNA-Trp (UGA/G)
- HGNC 7501(opens in a new tab)
- Ensembl gene ENSG00000210117(opens in a new tab)
- NCBI Gene 4578(opens in a new tab)
Summary
- Cytogenetic location
- mitochondria
- Also known as
- trnW
- Previous symbols
- MTTW
- Locus type
- RNA, transfer
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read MT-TW, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome TestCurated reports relevant to this gene
No Genome Test report reads MT-TW yet. The test sequences your whole genome, so your data includes it all the same.
How a genome test reads MT-TW
4
positions in MT-TW where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
Traits linked to MT-TW
The Human Phenotype Ontology lists these as features of the rare conditions MT-TW can cause. Each trait's page lists the other genes linked to it.
Abnormality of the nervous system
- Absent/small cerebral white matter
- Dementia
- Difficulty finding words
- EEG abnormality
- Epilepsy
- Migraine
- Widened cerebral subarachnoid space
- Abnormal gait
Show 48 more traits
- Anxiety
- Ataxia
- Chorea
- Depression
- Disorder of involuntary muscle movements
- Dystonia
- Encephalopathy
- Fluctuations in consciousness
- Focal T2 hyperintense basal ganglia lesion
- Generalized myoclonic seizure
- Grand mal seizures
- Impaired visuospatial constructive cognition
- Inability to coordinate movements when walking
- Jerking
- Memory impairment
- Nerve damage causing decreased feeling and movement
- Peripheral neuropathy
- Psychosis
- Recurrent paroxysmal headache
- Seizure affecting one half of brain
- Severe global developmental delay
- Short attention span
- Specific learning disability
- Weakness of one side of body
- Abnormal central motor function
- Abnormal prosody
- Agenesis of corpus callosum
- Bipolar disorder
- Brain degeneration
- Bulbar signs
- Decrease in size of the outer layer of the brain due to loss of brain cells
- Decreased reflex response
- Demyelinating peripheral neuropathy
- Distal peripheral sensory neuropathy
- Disturbances of consciousness
- Elevated brain lactate level by MRS
- Global developmental delay
- Increased reflexes
- Infantile spasms
- Loss of developmental milestones
- Mixed demyelinating and axonal polyneuropathy
- Motor delay
- Peripheral axonal neuropathy
- Personality changes
- Psychotic mentation
- Segmental peripheral demyelination/remyelination
- Stuttering
- Underdevelopment of part of brain called corpus callosum
Abnormality of the eye
- Pigmentary retinopathy
- Visual loss
- Weakness of muscles controlling eye movement
- Involuntary, rapid, rhythmic eye movements
- Optic atrophy
- Progressive external ophthalmoplegia
- Rod-cone dystrophy
- Cerebral visual impairment
Show 3 more traits
Abnormality of the digestive system
- Episodic vomiting
- Vomiting
- Constipation
- Diarrhea
- Enlarged liver
- Gastrointestinal dysmotility
- Intestinal pseudo-obstruction
- Liver failure
Show 2 more traits
External links
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). MT-TW gene: mitochondrially encoded tRNA-Trp (UGA/G). Retrieved 16 October 2026, from https://dantelabs.com/genes/mt-tw
Dante Labs. MT-TW gene: mitochondrially encoded tRNA-Trp (UGA/G) [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/mt-tw
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks