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Gene

ITGA8

integrin subunit alpha 8

Summary

Cytogenetic location
10p13
Coordinates
Chromosome 10: 15,513,954–15,719,922 (GRCh38)
Exons
30 exons across 206 kb
Protein
1,063 amino acids
Inheritance
Autosomal recessive
MANE Select transcript
ENST00000378076.4NM_003638.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How ITGA8 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 10, with a bracket where ITGA8 sits. ITGA8 and 4 genes near it on chromosome 10, from 15,116,938 to 16,116,937.Chromosome 1010p13p15.3p15.2p15.1p14p13p12.33p12.32p12.31p12.2p12.1p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.31q23.32q23.33q24.1q24.2q24.31q24.32q24.33q25.1q25.2q25.3q26.11q26.12q26.13q26.2q26.315.2 Mb15.4 Mb15.6 Mb15.8 Mb16 MbRPP38: 15,097,073–15,139,818, forward strandRPP38NMT2: 15,102,584–15,168,724, reverse strandNMT2FAM171A1: 15,211,324–15,371,309, reverse strandFAM171A1ITGA8: 15,513,954–15,719,922, reverse strandITGA8MINDY3: 15,776,915–15,860,553, reverse strandMINDY3Diagram of ITGA8: 30 exons on the reverse strand of chromosome 10Exon 27: 2 known disease-causing sitesExon 25: 1 known disease-causing siteExon 13: 1 known disease-causing siteExon 4: 2 known disease-causing sitesExon 1: 1 known disease-causing siteExon 30: 15,513,954–15,517,244, 3,291 basesExon 29: 15,519,290–15,519,412, 123 basesExon 28: 15,531,050–15,531,151, 102 basesExon 27: 15,548,455–15,548,568, 114 basesExon 26: 15,558,074–15,558,202, 129 basesExon 25: 15,572,211–15,572,369, 159 basesExon 24: 15,575,489–15,575,594, 106 basesExon 23: 15,586,584–15,586,664, 81 basesExon 22: 15,592,225–15,592,304, 80 basesExon 21: 15,597,207–15,597,299, 93 basesExon 20: 15,604,208–15,604,355, 148 basesExon 19: 15,605,724–15,605,791, 68 basesExon 18: 15,606,285–15,606,422, 138 basesExon 17: 15,607,677–15,607,831, 155 basesExon 16: 15,608,235–15,608,290, 56 basesExon 15: 15,613,660–15,613,767, 108 basesExon 14: 15,616,514–15,616,559, 46 basesExon 13: 15,644,030–15,644,221, 192 basesExon 12: 15,646,846–15,647,051, 206 basesExon 11: 15,655,354–15,655,406, 53 basesExon 10: 15,658,999–15,659,055, 57 basesExon 9: 15,660,879–15,660,922, 44 basesExon 8: 15,671,603–15,671,647, 45 basesExon 7: 15,672,624–15,672,749, 126 basesExon 6: 15,677,592–15,677,637, 46 basesExon 5: 15,678,722–15,678,783, 62 basesExon 4: 15,684,004–15,684,127, 124 basesExon 3: 15,687,938–15,688,038, 101 basesExon 2: 15,718,766–15,718,899, 134 basesExon 1: 15,719,563–15,719,922, 360 bases3025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 6.5 kb of the gene's 206 kb; 3,192 of those bases code for the protein.

How a genome test reads ITGA8

10

positions in ITGA8 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 206 kb of ITGA8, introns included, not only the 6.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ITGA8 gene: integrin subunit alpha 8. Retrieved 17 October 2026, from https://dantelabs.com/genes/itga8

Vancouver

Dante Labs. ITGA8 gene: integrin subunit alpha 8 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/itga8

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