Gene
WDR73
WD repeat domain 73
- HGNC 25928↗(opens in a new tab)
- Ensembl gene ENSG00000177082↗(opens in a new tab)
- NCBI Gene 84942↗(opens in a new tab)
Summary
- Cytogenetic location
- 15q25.2
- Coordinates
- Chromosome 15: 84,639,285–84,654,283 (GRCh38)
- Exons
- 8 exons across 15 kb
- Protein
- 378 amino acids
- Also known as
- FLJ14888, HSPC264
- MANE Select transcript
- ENST00000434634.7NM_032856.5
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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No Genome Test report reads WDR73 yet. The test sequences your whole genome, so your data includes it all the same.
How WDR73 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
- Stretches short reads find hard
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 5.3 kb of the gene's 15 kb; 1,137 of those bases code for the protein.
How a genome test reads WDR73
22
positions in WDR73 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 15 kb of WDR73, introns included, not only the 5.3 kb of exons.
Traits linked to WDR73
The Human Phenotype Ontology lists these as features of the rare conditions WDR73 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the nervous system
- Degeneration of cerebellum
- Intellectual disability
- Absent/small cerebellum
- Ataxia
- Cognitive impairment
- Delayed speech and language development
- Global developmental delay
- Motor delay
Show 17 more traits
- Progressive extrapyramidal movement disorder
- Abnormality of neuronal migration
- Brain degeneration
- Degeneration of cerebrum
- Difficulty articulating speech
- Difficulty sleeping
- Dystonia
- EEG abnormality
- Epilepsy
- Fewer and broader ridges in brain
- Aqueductal stenosis
- Paralysis or weakness of one side of body
- Increased reflexes
- Poor speech
- Small brainstem
- Underdevelopment of part of brain called corpus callosum
- Ventriculomegaly
Abnormality of the eye
- Optic atrophy
- Abnormally close eyes
- Wide-set eyes
- Abnormally small eyeball
- Clouding of the lens of the eye
- Cross-eyed
- Drooping upper eyelid
- Involuntary, rapid, rhythmic eye movements
Show 2 more traits
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). WDR73 gene: WD repeat domain 73. Retrieved 17 October 2026, from https://dantelabs.com/genes/wdr73
Dante Labs. WDR73 gene: WD repeat domain 73 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/wdr73
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