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Gene

STAT2

signal transducer and activator of transcription 2

Summary

Cytogenetic location
12q13.3
Coordinates
Chromosome 12: 56,341,597–56,360,107 (GRCh38)
Exons
24 exons across 18.5 kb
Protein
851 amino acids
Also known as
STAT113
MANE Select transcript
ENST00000314128.9NM_005419.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Other Inborn Errors of Immunity

      • Inborn error of immunity

        One of 114 genes linked to it

        Inherited disorders of the immune system caused by changes in single genes, affecting how the body fights infection or regulates inflammation.

        • 2 GenCC submitters rate it definitive or strong
      • Immunodeficiency Disease

        One of 170 genes linked to it

        Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

        • 2 GenCC submitters rate it definitive or strong
        What knowing changes

        HSCT for SCID and severe PIDs; immunoglobulin replacement (IVIG/SCIG) for antibody deficiencies; leniolisib (Joenja, FDA 2023) for APDS; gene therapy for ADA-SCID; abatacept for CTLA4/LRBA deficiency; prophylactic antibiotics; G-CSF for CGD

    How STAT2 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 12, with a bracket where STAT2 sits. STAT2 and 41 genes near it on chromosome 12, from 55,850,852 to 56,850,851.Chromosome 1212q13.3p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3356 Mb56.2 Mb56.4 Mb56.6 Mb56.8 MbPYM1: 55,901,413–55,932,618, reverse strandPYM1DGKA: 55,927,319–55,954,027, forward strandDGKAPMEL: 55,954,104–55,973,317, reverse strandPMELCDK2: 55,966,781–55,972,789, forward strandCDK2RAB5B: 55,973,859–55,996,683, forward strandRAB5BSUOX: 55,996,855–56,006,641, forward strandSUOXIKZF4: 56,007,392–56,038,435, forward strandIKZF4RPS26: 56,041,351–56,044,697, forward strandRPS26ERBB3: 56,076,799–56,103,505, forward strand: 56,101,331–56,109,289, forward strandPA2G4: 56,104,349–56,116,329, forward strandRPL41: 56,116,585–56,117,967, forward strandZC3H10: 56,118,243–56,127,514, forward strandESYT1: 56,118,250–56,150,107, forward strandESYT1MYL6B: 56,151,966–56,159,647, forward strandMYL6BMYL6: 56,158,322–56,166,572, forward strandMYL6SMARCC2: 56,162,359–56,189,587, reverse strandSMARCC2RNF41: 56,202,179–56,224,275, reverse strandNABP2: 56,221,978–56,229,860, forward strandNABP2SLC39A5: 56,230,039–56,238,214, forward strandSLC39A5ANKRD52: 56,237,807–56,258,665, reverse strandANKRD52COQ10A: 56,266,846–56,271,736, forward strandCOQ10ACS: 56,271,699–56,300,395, reverse strandCS: 56,285,916–56,316,059, reverse strandCNPY2: 56,308,024–56,316,363, reverse strandCNPY2PAN2: 56,316,223–56,334,053, reverse strandPAN2IL23A: 56,334,174–56,340,410, forward strandIL23ASTAT2: 56,341,597–56,360,107, reverse strandSTAT2APOF: 56,360,565–56,362,862, reverse strandAPOFTIMELESS: 56,416,363–56,449,457, reverse strandTIMELESSMIP: 56,449,502–56,469,166, reverse strandMIP: 56,449,700–56,488,170, reverse strandSPRYD4: 56,468,537–56,479,708, forward strandSPRYD4GLS2: 56,470,945–56,488,414, reverse strandRBMS2: 56,521,807–56,617,037, forward strandRBMS2BAZ2A: 56,595,596–56,636,914, reverse strandBAZ2AATP5F1B: 56,637,490–56,646,079, reverse strandATP5F1BPTGES3: 56,651,663–56,688,408, reverse strandPTGES3NACA: 56,712,305–56,731,628, reverse strandNACA: 56,714,612–56,741,535, reverse strandPRIM1: 56,730,438–56,752,384, reverse strandPRIM1HSD17B6: 56,751,817–56,788,409, forward strandHSD17B6Diagram of STAT2: 24 exons on the reverse strand of chromosome 12Exon 23: 2 known disease-causing sitesExon 21: 1 known disease-causing siteExon 20: 4 known disease-causing sitesExon 19: 2 known disease-causing sitesExon 18: 1 known disease-causing siteExon 17: 3 known disease-causing sitesExon 13: 1 known disease-causing siteExon 10: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 8: 3 known disease-causing sitesExon 5: 2 known disease-causing sitesExon 3: 1 known disease-causing siteExon 2: 2 known disease-causing sitesExon 24: 56,341,597–56,343,531, 1,935 basesExon 23: 56,343,825–56,344,135, 311 basesExon 22: 56,346,146–56,346,203, 58 basesExon 21: 56,346,442–56,346,624, 183 basesExon 20: 56,346,819–56,346,955, 137 basesExon 19: 56,348,529–56,348,623, 95 basesExon 18: 56,348,752–56,348,804, 53 basesExon 17: 56,348,924–56,349,059, 136 basesExon 16: 56,349,163–56,349,261, 99 basesExon 15: 56,349,426–56,349,509, 84 basesExon 14: 56,349,589–56,349,636, 48 basesExon 13: 56,350,097–56,350,190, 94 basesExon 12: 56,350,412–56,350,432, 21 basesExon 11: 56,350,829–56,350,888, 60 basesExon 10: 56,351,098–56,351,190, 93 basesExon 9: 56,351,292–56,351,450, 159 basesExon 8: 56,354,466–56,354,614, 149 basesExon 7: 56,354,778–56,354,863, 86 basesExon 6: 56,355,276–56,355,351, 76 basesExon 5: 56,355,443–56,355,532, 90 basesExon 4: 56,355,708–56,355,803, 96 basesExon 3: 56,356,132–56,356,285, 154 basesExon 2: 56,356,441–56,356,578, 138 basesExon 1: 56,360,058–56,360,107, 50 bases24201510515′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 4.4 kb of the gene's 18.5 kb; 2,556 of those bases code for the protein.

    How a genome test reads STAT2

    30

    positions in STAT2 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 18.5 kb of STAT2, introns included, not only the 4.4 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). STAT2 gene: signal transducer and activator of transcription 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/stat2

    Vancouver

    Dante Labs. STAT2 gene: signal transducer and activator of transcription 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/stat2

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