Skip to content
Use your HSA or FSA funds

Gene

PTPN22

protein tyrosine phosphatase non-receptor type 22

Summary

Cytogenetic location
1p13.2
Coordinates
Chromosome 1: 113,813,811–113,871,712 (GRCh38)
Exons
21 exons across 57.9 kb
Protein
807 amino acids
Also known as
Lyp, Lyp1, Lyp2
Previous symbols
PTPN8
MANE Select transcript
ENST00000359785.10NM_015967.8
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads PTPN22 yet. The test sequences your whole genome, so your data includes it all the same.

How PTPN22 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 1, with a bracket where PTPN22 sits. PTPN22 and 9 genes near it on chromosome 1, from 113,342,762 to 114,342,761.Chromosome 11p13.2p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44113.4 Mb113.6 Mb113.8 Mb114 Mb114.2 MbMAGI3: 113,390,390–113,687,431, forward strandMAGI3PHTF1: 113,696,052–113,759,908, reverse strandPHTF1RSBN1: 113,761,429–113,812,551, reverse strandRSBN1PTPN22: 113,813,811–113,871,712, reverse strandPTPN22BCL2L15: 113,876,816–113,887,588, reverse strandBCL2L15AP4B1: 113,894,194–113,905,722, reverse strandAP4B1DCLRE1B: 113,904,403–113,914,140, forward strandDCLRE1BHIPK1: 113,929,324–113,977,869, forward strandHIPK1OLFML3: 113,979,024–114,035,572, forward strandOLFML3SYT6: 114,089,291–114,153,880, reverse strandSYT6Diagram of PTPN22: 21 exons on the reverse strand of chromosome 1Exon 21: 113,813,811–113,814,969, 1,159 basesExon 20: 113,819,577–113,819,654, 78 basesExon 19: 113,825,142–113,825,172, 31 basesExon 18: 113,829,592–113,829,707, 116 basesExon 17: 113,829,949–113,830,029, 81 basesExon 16: 113,833,111–113,833,138, 28 basesExon 15: 113,834,309–113,834,439, 131 basesExon 14: 113,834,910–113,834,993, 84 basesExon 13: 113,837,590–113,838,407, 818 basesExon 12: 113,838,544–113,838,620, 77 basesExon 11: 113,848,540–113,848,626, 87 basesExon 10: 113,852,027–113,852,104, 78 basesExon 9: 113,854,471–113,854,537, 67 basesExon 8: 113,854,907–113,855,049, 143 basesExon 7: 113,856,382–113,856,441, 60 basesExon 6: 113,856,548–113,856,619, 72 basesExon 5: 113,857,738–113,857,776, 39 basesExon 4: 113,858,478–113,858,573, 96 basesExon 3: 113,859,002–113,859,078, 77 basesExon 2: 113,859,352–113,859,460, 109 basesExon 1: 113,871,537–113,871,712, 176 bases21201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.6 kb of the gene's 57.9 kb; 2,424 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.

Cite this page

APA

Dante Labs. (n.d.). PTPN22 gene: protein tyrosine phosphatase non-receptor type 22. Retrieved 17 October 2026, from https://dantelabs.com/genes/ptpn22

Vancouver

Dante Labs. PTPN22 gene: protein tyrosine phosphatase non-receptor type 22 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ptpn22

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test