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Gene

H19

H19 imprinted maternally expressed transcript

Summary

Cytogenetic location
11p15.5
Coordinates
Chromosome 11: 1,995,176–1,997,842 (GRCh38)
Exons
5 exons across 2.7 kb
Inheritance
Autosomal dominant
Also known as
D11S813E, ASM, ASM1, NCRNA00008, LINC00008, MIR675HG, GMRSP
MANE Select transcript
ENST00000414790.11NR_002196.3
Locus type
RNA, long non-coding

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Imprinting Disorders: Prader-Willi, Silver-Russell and Beckwith-Wiedemann

    • Beckwith-Wiedemann syndrome

      An overgrowth disorder caused by imprinting changes at 11p15 (and sometimes CDKN1C variants) that can cause large birth size, an enlarged tongue, abdominal wall defects and a higher risk of childhood tumours such as Wilms tumour.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Diagnosis leads to childhood tumour surveillance, including abdominal ultrasound.

Broader groupings

  • Hypertrophic Cardiomyopathy

    • Autosomal dominant

      One of 62 genes linked to it

      A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Beta-blockers, non-dihydropyridine calcium channel blockers, activity restriction, genetic counseling

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How H19 is laid out

  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 11, with a bracket where H19 sits. H19 and 29 genes near it on chromosome 11, from 1,496,509 to 2,496,508.Chromosome 1111p15.5p15.5p15.4p15.3p15.2p15.1p14.3p14.2p14.1p13p12p11.2p11.12p11.11q11q12.1q12.2q12.3q13.1q13.2q13.3q13.4q13.5q14.1q14.2q14.3q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q251.6 Mb1.8 Mb2 Mb2.2 Mb2.4 MbMOB2: 1,469,457–1,501,247, reverse strandMOB2DUSP8: 1,554,051–1,573,076, reverse strandKRTAP5-1: 1,584,342–1,585,283, reverse strandKRTAP5-2: 1,597,177–1,598,294, reverse strandKRTAP5-2KRTAP5-3: 1,607,565–1,608,463, reverse strandKRTAP5-3KRTAP5-4: 1,620,958–1,622,138, reverse strandKRTAP5-4KRTAP5-5: 1,629,775–1,630,930, forward strandKRTAP5-5KRTAP5-6: 1,697,195–1,697,755, forward strandKRTAP5-6IFITM10: 1,732,406–1,750,607, reverse strandIFITM10: 1,734,821–1,763,954, reverse strandCTSD: 1,752,752–1,764,573, reverse strandCTSDSYT8: 1,828,307–1,837,521, forward strandSYT8TNNI2: 1,838,971–1,841,680, forward strandTNNI2LSP1: 1,850,904–1,892,267, forward strandLSP1PRR33: 1,888,078–1,917,713, reverse strandPRR33TNNT3: 1,919,456–1,938,711, forward strandTNNT3MRPL23: 1,947,278–2,014,943, forward strandMRPL23H19: 1,995,176–1,997,842, reverse strandH19: 2,129,112–2,149,603, reverse strandIGF2: 2,129,112–2,158,596, reverse strandIGF2INS-IGF2: 2,132,538–2,161,209, reverse strandINS-IGF2INS: 2,159,779–2,161,221, reverse strandINSTH: 2,163,929–2,171,968, reverse strandASCL2: 2,268,498–2,271,040, reverse strandASCL2C11orf21: 2,295,628–2,303,180, reverse strandC11orf21TSPAN32: 2,301,981–2,318,204, forward strandTSPAN32CD81: 2,376,166–2,398,079, forward strandCD81TSSC4: 2,400,488–2,403,878, forward strandTSSC4TRPM5: 2,404,515–2,444,519, reverse strandTRPM5KCNQ1: 2,444,654–2,849,105, forward strandKCNQ1Diagram of H19: 5 exons on the reverse strand of chromosome 11Exon 5: 1,995,176–1,995,794, 619 basesExon 4: 1,995,876–1,995,998, 123 basesExon 3: 1,996,079–1,996,191, 113 basesExon 2: 1,996,287–1,996,421, 135 basesExon 1: 1,996,518–1,997,842, 1,325 bases543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.3 kb of the gene's 2.7 kb.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). H19 gene: H19 imprinted maternally expressed transcript. Retrieved 16 October 2026, from https://dantelabs.com/genes/h19

Vancouver

Dante Labs. H19 gene: H19 imprinted maternally expressed transcript [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/h19

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