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Gene

WWOX

WW domain containing oxidoreductase

Summary

Cytogenetic location
16q23.1-q23.2
Coordinates
Chromosome 16: 78,099,654–79,212,667 (GRCh38)
Exons
9 exons across 1,113 kb
Protein
414 amino acids
Inheritance
Autosomal recessive
Also known as
FOR, WOX1, SDR41C1
MANE Select transcript
ENST00000566780.6NM_016373.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

    • Autosomal Recessive Cerebellar Ataxias (incl. CANVAS and AVED)

      • Autosomal Recessive Cerebellar AtaxiaAutosomal recessive

        One of 57 genes linked to it

        A group of recessively inherited ataxias caused by biallelic variants in genes such as RFC1, FXN, SACS, TTPA, SETX, APTX, PNKP, ANO10 and SYNE1.

        • 3 GenCC submitters rate it definitive or strong
        What knowing changes

        Ataxia with vitamin E deficiency (TTPA) is treatable with vitamin E supplements; other forms are managed with physiotherapy and symptom care, and relatives can be offered carrier testing.

    • Epilepsy (Full Panel)

      • Epilepsy

        One of 171 genes linked to it

        A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

        • ClinGen rates the link definitive
        • 4 GenCC submitters rate it definitive or strong

    Inheritance

    Autosomal recessive
    It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

    How WWOX is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 16, with a bracket where WWOX sits. WWOX and 7 genes near it on chromosome 16, from 76,986,640 to 80,325,681.Chromosome 1616q23.1-q23.2p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.377 Mb77.5 Mb78 Mb78.5 Mb79 Mb79.5 Mb80 MbMON1B: 77,190,835–77,202,398, forward strandMON1BSYCE1L: 77,199,400–77,213,215, forward strandSYCE1LADAMTS18: 77,247,813–77,435,034, reverse strandADAMTS18NUDT7: 77,722,474–77,776,042, forward strandNUDT7VAT1L: 77,788,527–77,980,107, forward strandVAT1LCLEC3A: 78,022,515–78,066,761, forward strandCLEC3AWWOX: 78,099,654–79,212,667, forward strandWWOXMAF: 79,583,128–79,600,737, reverse strandMAFDiagram of WWOX: 9 exons on the forward strand of chromosome 16Exon 1: 7 known disease-causing sitesExon 2: 4 known disease-causing sitesExon 3: 4 known disease-causing sitesExon 4: 4 known disease-causing sitesExon 5: 5 known disease-causing sitesExon 6: 4 known disease-causing sitesExon 7: 7 known disease-causing sitesExon 8: 12 known disease-causing sitesExon 9: 5 known disease-causing sitesExon 1: 78,099,654–78,099,885, 232 basesExon 2: 78,108,423–78,108,487, 65 basesExon 3: 78,109,778–78,109,835, 58 basesExon 4: 78,114,976–78,115,154, 179 basesExon 5: 78,164,183–78,164,289, 107 basesExon 6: 78,386,860–78,386,948, 89 basesExon 7: 78,424,870–78,425,055, 186 basesExon 8: 78,432,488–78,432,752, 265 basesExon 9: 79,211,608–79,212,667, 1,060 bases1595′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 2.2 kb of the gene's 1,113 kb; 1,245 of those bases code for the protein.

    How a genome test reads WWOX

    73

    positions in WWOX where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 1,113 kb of WWOX, introns included, not only the 2.2 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). WWOX gene: WW domain containing oxidoreductase. Retrieved 17 October 2026, from https://dantelabs.com/genes/wwox

    Vancouver

    Dante Labs. WWOX gene: WW domain containing oxidoreductase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/wwox

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