Skip to content
Use your HSA or FSA funds

Gene

NLRP12

NLR family pyrin domain containing 12

Summary

Cytogenetic location
19q13.42
Coordinates
Chromosome 19: 53,793,741–53,824,314 (GRCh38)
Exons
10 exons across 30.6 kb
Protein
1,061 amino acids
Inheritance
Autosomal dominant
Also known as
RNO2, PYPAF7, Monarch1, PAN6, CLR19.3
Previous symbols
NALP12
MANE Select transcript
ENST00000324134.11NM_144687.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hereditary Periodic Fever Syndromes

    • Cryopyrin-associated periodic syndrome (CAPS)Autosomal dominant

      A spectrum of conditions caused mainly by changes in NLRP3, ranging from cold-induced rashes and fevers to chronic inflammation affecting the skin, joints, hearing and brain.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Interleukin-1 blocking treatment controls symptoms and helps prevent hearing loss and amyloidosis.

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How NLRP12 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 19, with a bracket where NLRP12 sits. NLRP12 and 29 genes near it on chromosome 19, from 53,309,028 to 54,309,027.Chromosome 1919q13.42p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4353.4 Mb53.6 Mb53.8 Mb54 Mb54.2 MbZNF845: 53,333,733–53,357,023, forward strandZNF845ZNF525: 53,365,671–53,393,980, forward strandZNF525ZNF765: 53,389,793–53,430,413, forward strandZNF765ZNF761: 53,431,948–53,462,809, forward strandZNF761ZNF813: 53,467,703–53,496,255, forward strandZNF813ZNF331: 53,519,527–53,580,271, forward strandZNF331DPRX: 53,600,777–53,637,014, forward strandDPRXNLRP12: 53,793,741–53,824,314, reverse strandNLRP12MYADM: 53,864,763–53,878,125, forward strandMYADMPRKCG: 53,879,190–53,907,652, forward strandPRKCGCACNG7: 53,909,264–53,943,950, forward strandCACNG7CACNG8: 53,962,937–53,990,215, forward strandCACNG8CACNG6: 53,991,605–54,012,670, forward strandCACNG6VSTM1: 54,040,825–54,063,959, reverse strandVSTM1TARM1: 54,069,895–54,081,365, reverse strandTARM1OSCAR: 54,094,668–54,102,692, reverse strandOSCARNDUFA3: 54,102,728–54,111,522, forward strandNDUFA3TFPT: 54,107,015–54,115,666, reverse strandTFPTPRPF31: 54,115,410–54,131,719, forward strandCNOT3: 54,137,710–54,155,708, forward strandLENG1: 54,155,161–54,159,760, reverse strandLENG1TMC4: 54,160,095–54,173,250, reverse strandTMC4MBOAT7: 54,173,412–54,189,882, reverse strandMBOAT7TSEN34: 54,188,464–54,194,538, forward strandTSEN34RPS9: 54,200,466–54,249,003, forward strandRPS9LILRB3: 54,215,940–54,223,506, reverse strandLILRB3LILRA6: 54,236,590–54,242,820, reverse strandLILRB5: 54,249,421–54,257,339, reverse strandLILRB5LILRB2: 54,273,812–54,281,184, reverse strandLILRA5: 54,307,037–54,313,177, reverse strandLILRA5Diagram of NLRP12: 10 exons on the reverse strand of chromosome 19Exon 8: 1 known disease-causing siteExon 7: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 3: 5 known disease-causing sitesExon 1: 1 known disease-causing siteExon 10: 53,793,741–53,794,136, 396 basesExon 9: 53,795,859–53,796,029, 171 basesExon 8: 53,798,243–53,798,413, 171 basesExon 7: 53,801,227–53,801,397, 171 basesExon 6: 53,803,952–53,804,122, 171 basesExon 5: 53,805,280–53,805,450, 171 basesExon 4: 53,807,495–53,807,665, 171 basesExon 3: 53,809,587–53,811,288, 1,702 basesExon 2: 53,814,908–53,814,988, 81 basesExon 1: 53,823,886–53,824,314, 429 bases109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.6 kb of the gene's 30.6 kb; 3,186 of those bases code for the protein.

How a genome test reads NLRP12

13

positions in NLRP12 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 30.6 kb of NLRP12, introns included, not only the 3.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NLRP12 gene: NLR family pyrin domain containing 12. Retrieved 16 October 2026, from https://dantelabs.com/genes/nlrp12

Vancouver

Dante Labs. NLRP12 gene: NLR family pyrin domain containing 12 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/nlrp12

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test