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Gene

TET2

tet methylcytosine dioxygenase 2

Summary

Cytogenetic location
4q24
Coordinates
Chromosome 4: 105,146,876–105,279,803 (GRCh38)
Exons
11 exons across 132.9 kb
Protein
2,002 amino acids
Also known as
FLJ20032
Previous symbols
KIAA1546
MANE Select transcript
ENST00000380013.9NM_001127208.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Other Inborn Errors of Immunity

      • Immunodeficiency Disease

        One of 170 genes linked to it

        Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

        • 2 GenCC submitters rate it definitive or strong
        What knowing changes

        HSCT for SCID and severe PIDs; immunoglobulin replacement (IVIG/SCIG) for antibody deficiencies; leniolisib (Joenja, FDA 2023) for APDS; gene therapy for ADA-SCID; abatacept for CTLA4/LRBA deficiency; prophylactic antibiotics; G-CSF for CGD

    How TET2 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 4, with a bracket where TET2 sits. TET2 and 4 genes near it on chromosome 4, from 104,713,340 to 105,713,339.Chromosome 44q24p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.2104.8 Mb105 Mb105.2 Mb105.4 Mb105.6 MbTET2: 105,146,876–105,279,803, forward strandTET2PPA2: 105,357,684–105,474,113, reverse strandPPA2ARHGEF38: 105,552,484–105,708,093, forward strandARHGEF38INTS12: 105,682,014–105,895,986, reverse strandINTS12GSTCD: 105,708,774–105,849,570, forward strandGSTCDDiagram of TET2: 11 exons on the forward strand of chromosome 4Exon 3: 5 known disease-causing sitesExon 6: 2 known disease-causing sitesExon 1: 105,146,876–105,146,979, 104 basesExon 2: 105,190,360–105,190,505, 146 basesExon 3: 105,233,897–105,237,351, 3,455 basesExon 4: 105,241,339–105,241,429, 91 basesExon 5: 105,242,834–105,242,927, 94 basesExon 6: 105,243,570–105,243,778, 209 basesExon 7: 105,259,619–105,259,769, 151 basesExon 8: 105,261,759–105,261,848, 90 basesExon 9: 105,269,610–105,269,747, 138 basesExon 10: 105,272,564–105,272,918, 355 basesExon 11: 105,275,048–105,279,803, 4,756 bases1246810115′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 9.6 kb of the gene's 132.9 kb; 6,009 of those bases code for the protein.

    How a genome test reads TET2

    8

    positions in TET2 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 132.9 kb of TET2, introns included, not only the 9.6 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). TET2 gene: tet methylcytosine dioxygenase 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/tet2

    Vancouver

    Dante Labs. TET2 gene: tet methylcytosine dioxygenase 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tet2

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