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Gene

UNG

uracil DNA glycosylase

Summary

Cytogenetic location
12q24.11
Coordinates
Chromosome 12: 109,097,597–109,110,992 (GRCh38)
Exons
7 exons across 13.4 kb
Protein
313 amino acids
Also known as
UDG, UNG1, UNG2, HIGM4
Previous symbols
DGU
MANE Select transcript
ENST00000242576.7NM_080911.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Hyper-IgM Syndromes

    • Hyper-IgM syndrome

      Defective antibody class switching caused by changes in CD40LG (X-linked), CD40, AICDA or UNG.

      • ClinGen rates the link moderate
      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Immunoglobulin replacement is standard; CD40L and CD40 deficiency also need Pneumocystis prophylaxis, safe drinking water to prevent cryptosporidium and consideration of stem cell transplantation.

Broader groupings

  • Other Inborn Errors of Immunity

    • Inborn error of immunity

      One of 114 genes linked to it

      Inherited disorders of the immune system caused by changes in single genes, affecting how the body fights infection or regulates inflammation.

      • ClinGen rates the link moderate
      • 2 GenCC submitters rate it definitive or strong
    • Immunodeficiency Disease

      One of 170 genes linked to it

      Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

      • ClinGen rates the link moderate
      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      HSCT for SCID and severe PIDs; immunoglobulin replacement (IVIG/SCIG) for antibody deficiencies; leniolisib (Joenja, FDA 2023) for APDS; gene therapy for ADA-SCID; abatacept for CTLA4/LRBA deficiency; prophylactic antibiotics; G-CSF for CGD

How UNG is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 12, with a bracket where UNG sits. UNG and 14 genes near it on chromosome 12, from 108,604,295 to 109,604,294.Chromosome 1212q24.11p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.33108.8 Mb109 Mb109.2 Mb109.4 Mb109.6 MbSELPLG: 108,620,413–108,633,894, reverse strandSELPLGCORO1C: 108,645,109–108,760,599, reverse strandCORO1CSSH1: 108,778,191–108,857,637, reverse strandSSH1DAO: 108,858,932–108,901,052, forward strandDAOSVOP: 108,907,741–109,021,068, reverse strandSVOPUSP30: 109,023,089–109,088,023, forward strandUSP30ALKBH2: 109,085,154–109,098,462, reverse strandALKBH2UNG: 109,097,597–109,110,992, forward strandUNGACACB: 109,116,320–109,268,226, forward strandACACBFOXN4: 109,277,978–109,309,289, reverse strandFOXN4MYO1H: 109,347,900–109,455,523, forward strandMYO1HKCTD10: 109,448,655–109,477,359, reverse strandKCTD10UBE3B: 109,477,375–109,536,705, forward strandUBE3BMMAB: 109,553,715–109,573,580, reverse strandMMABMVK: 109,573,255–109,600,609, forward strandMVKDiagram of UNG: 7 exons on the forward strand of chromosome 12Exon 1: 1 known disease-causing siteExon 2: 5 known disease-causing sitesExon 3: 3 known disease-causing sitesExon 4: 1 known disease-causing siteExon 5: 2 known disease-causing sitesExon 6: 4 known disease-causing sitesExon 1: 109,097,597–109,097,811, 215 basesExon 2: 109,098,432–109,098,638, 207 basesExon 3: 109,099,189–109,099,284, 96 basesExon 4: 109,101,902–109,101,999, 98 basesExon 5: 109,102,839–109,102,927, 89 basesExon 6: 109,103,433–109,103,611, 179 basesExon 7: 109,109,829–109,110,992, 1,164 bases12345675′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2 kb of the gene's 13.4 kb; 942 of those bases code for the protein.

How a genome test reads UNG

20

positions in UNG where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 13.4 kb of UNG, introns included, not only the 2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). UNG gene: uracil DNA glycosylase. Retrieved 17 October 2026, from https://dantelabs.com/genes/ung

Vancouver

Dante Labs. UNG gene: uracil DNA glycosylase [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ung

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