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Gene

IL23R

interleukin 23 receptor

Summary

Cytogenetic location
1p31.3
Coordinates
Chromosome 1: 67,166,454–67,259,979 (GRCh38)
Exons
11 exons across 93.5 kb
Protein
629 amino acids
Also known as
IL-23R
MANE Select transcript
ENST00000347310.10NM_144701.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Mendelian Susceptibility to Mycobacterial Disease (MSMD)

    • Mendelian susceptibility to mycobacterial disease

      Inherited defects in the IL-12/interferon-gamma pathway, caused by genes such as IL12RB1, IL12B, IFNGR1, IFNGR2, STAT1, IRF8, ISG15 and RORC.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Affected people and at-risk relatives should avoid BCG and other live vaccines, infections need prolonged treatment, and some forms respond to interferon-gamma.

Broader groupings

  • Other Inborn Errors of Immunity

    • Immunodeficiency Disease

      One of 170 genes linked to it

      Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      HSCT for SCID and severe PIDs; immunoglobulin replacement (IVIG/SCIG) for antibody deficiencies; leniolisib (Joenja, FDA 2023) for APDS; gene therapy for ADA-SCID; abatacept for CTLA4/LRBA deficiency; prophylactic antibiotics; G-CSF for CGD

How IL23R is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 1, with a bracket where IL23R sits. IL23R and 11 genes near it on chromosome 1, from 66,713,217 to 67,713,216.Chromosome 11p31.3p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q4466.8 Mb67 Mb67.2 Mb67.4 Mb67.6 MbSGIP1: 66,533,267–66,751,139, forward strandSGIP1DYNLT5: 66,751,741–66,779,051, forward strandDYNLT5INSL5: 66,797,740–66,801,276, reverse strandINSL5DNAI4: 66,812,885–66,924,890, reverse strandDNAI4MIER1: 66,924,895–66,989,411, forward strandMIER1SLC35D1: 66,945,905–67,054,400, reverse strandSLC35D1C1orf141: 67,092,005–67,231,853, reverse strandC1orf141IL23R: 67,166,454–67,259,979, forward strandIL23RIL12RB2: 67,307,364–67,398,724, forward strandIL12RB2SERBP1: 67,406,389–67,430,418, reverse strandSERBP1GADD45A: 67,685,048–67,691,165, forward strandGADD45AGNG12: 67,701,461–67,833,811, reverse strandGNG12Diagram of IL23R: 11 exons on the forward strand of chromosome 1Exon 1: 67,166,454–67,166,541, 88 basesExon 2: 67,168,092–67,168,190, 99 basesExon 3: 67,169,342–67,169,638, 297 basesExon 4: 67,182,836–67,182,959, 124 basesExon 5: 67,200,737–67,200,897, 161 basesExon 6: 67,206,910–67,207,055, 146 basesExon 7: 67,219,574–67,219,730, 157 basesExon 8: 67,236,713–67,236,802, 90 basesExon 9: 67,240,179–67,240,281, 103 basesExon 10: 67,255,837–67,255,927, 91 basesExon 11: 67,258,478–67,259,979, 1,502 bases1246810115′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.9 kb of the gene's 93.5 kb; 1,890 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). IL23R gene: interleukin 23 receptor. Retrieved 16 October 2026, from https://dantelabs.com/genes/il23r

Vancouver

Dante Labs. IL23R gene: interleukin 23 receptor [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/il23r

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