Skip to content
Use your HSA or FSA funds

Gene

IFNGR1

interferon gamma receptor 1

Summary

Cytogenetic location
6q23.3
Coordinates
Chromosome 6: 137,197,485–137,219,385 (GRCh38)
Exons
7 exons across 21.9 kb
Protein
489 amino acids
Also known as
CD119
Previous symbols
IFNGR
MANE Select transcript
ENST00000367739.9NM_000416.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Mendelian Susceptibility to Mycobacterial Disease (MSMD)

    • Mendelian susceptibility to mycobacterial disease

      Inherited defects in the IL-12/interferon-gamma pathway, caused by genes such as IL12RB1, IL12B, IFNGR1, IFNGR2, STAT1, IRF8, ISG15 and RORC.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Affected people and at-risk relatives should avoid BCG and other live vaccines, infections need prolonged treatment, and some forms respond to interferon-gamma.

How IFNGR1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 6, with a bracket where IFNGR1 sits. IFNGR1 and 6 genes near it on chromosome 6, from 136,708,435 to 137,708,434.Chromosome 66q23.3p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q27136.8 Mb137 Mb137.2 Mb137.4 Mb137.6 MbMAP3K5: 136,557,030–136,793,103, reverse strandMAP3K5PEX7: 136,822,546–136,914,598, forward strandPEX7SLC35D3: 136,921,923–136,925,660, forward strandSLC35D3IL20RA: 136,999,971–137,045,180, reverse strandIL20RAIL22RA2: 137,143,820–137,173,648, reverse strandIL22RA2IFNGR1: 137,197,485–137,219,385, reverse strandIFNGR1OLIG3: 137,492,199–137,494,394, reverse strandOLIG3Diagram of IFNGR1: 7 exons on the reverse strand of chromosome 6Exon 6: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 4: 2 known disease-causing sitesExon 3: 2 known disease-causing sitesExon 2: 1 known disease-causing siteExon 1: 1 known disease-causing siteExon 7: 137,197,485–137,198,639, 1,155 basesExon 6: 137,200,881–137,201,008, 128 basesExon 5: 137,203,499–137,203,685, 187 basesExon 4: 137,204,332–137,204,504, 173 basesExon 3: 137,206,136–137,206,308, 173 basesExon 2: 137,206,963–137,207,077, 115 basesExon 1: 137,219,243–137,219,385, 143 bases76543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.1 kb of the gene's 21.9 kb; 1,470 of those bases code for the protein.

How a genome test reads IFNGR1

10

positions in IFNGR1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 21.9 kb of IFNGR1, introns included, not only the 2.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). IFNGR1 gene: interferon gamma receptor 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/ifngr1

Vancouver

Dante Labs. IFNGR1 gene: interferon gamma receptor 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/ifngr1

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test