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Gene

SOCS1

suppressor of cytokine signaling 1

Summary

Cytogenetic location
16p13.13
Coordinates
Chromosome 16: 11,254,417–11,256,204 (GRCh38)
Exons
2 exons across 1.8 kb
Protein
211 amino acids
Inheritance
Autosomal dominant
Also known as
SOCS-1, SSI-1, JAB, TIP3, Cish1
MANE Select transcript
ENST00000332029.4NM_003745.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Rare Monogenic Autoinflammatory Diseases

    • SOCS1 haploinsufficiencyAutosomal dominant

      Early-onset autoimmunity and inflammation, such as lupus, low platelets and arthritis, caused by variants in SOCS1.

      • ClinGen rates the link definitive
      • 3 GenCC submitters rate it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How SOCS1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 16, with a bracket where SOCS1 sits. SOCS1 and 15 genes near it on chromosome 16, from 10,755,311 to 11,755,310.Chromosome 1616p13.13p13.3p13.2p13.13p13.12p13.11p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q13q21q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.310.8 Mb11 Mb11.2 Mb11.4 Mb11.6 MbNUBP1: 10,743,786–10,769,812, forward strandNUBP1TVP23A: 10,760,919–10,818,794, reverse strandTVP23ACIITA: 10,866,222–10,943,021, forward strandCIITADEXI: 10,928,891–10,942,481, reverse strandDEXICLEC16A: 10,944,508–11,189,745, forward strandCLEC16ARMI2: 11,249,619–11,381,662, forward strandSOCS1: 11,254,417–11,256,204, reverse strandSOCS1TNP2: 11,267,748–11,269,533, reverse strandTNP2PRM3: 11,273,199–11,273,629, reverse strandPRM3PRM2: 11,275,632–11,276,488, reverse strandPRM2PRM1: 11,280,836–11,281,398, reverse strandAPOLTP: 11,359,845–11,527,247, reverse strandAPOLTPLITAF: 11,546,224–11,640,269, reverse strandLITAFSNN: 11,668,027–11,679,164, forward strandSNNTXNDC11: 11,679,073–11,743,703, reverse strandTXNDC11ZC3H7A: 11,750,586–11,797,263, reverse strandZC3H7ADiagram of SOCS1: 2 exons on the reverse strand of chromosome 16Exon 2: 4 known disease-causing sitesExon 2: 11,254,417–11,255,528, 1,112 basesExon 1: 11,256,079–11,256,204, 126 bases215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.2 kb of the gene's 1.8 kb; 636 of those bases code for the protein.

How a genome test reads SOCS1

4

positions in SOCS1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 1.8 kb of SOCS1, introns included, not only the 1.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SOCS1 gene: suppressor of cytokine signaling 1. Retrieved 16 October 2026, from https://dantelabs.com/genes/socs1

Vancouver

Dante Labs. SOCS1 gene: suppressor of cytokine signaling 1 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/socs1

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