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Gene

CD70

CD70 molecule

Summary

Cytogenetic location
19p13.3
Coordinates
Chromosome 19: 6,585,839–6,591,150 (GRCh38)
Exons
3 exons across 5.3 kb
Protein
193 amino acids
Inheritance
Autosomal recessive
Also known as
CD27L, CD27-L
Previous symbols
CD27LG, TNFSF7
MANE Select transcript
ENST00000245903.4NM_001252.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Severe Combined Immunodeficiency

    • Autosomal recessive

      Severe combined immunodeficiency (SCID) comprises a group of rare monogenic primary immunodeficiency disorders characterized by a lack of functional peripheral T lymphocytes resulting in early-onset severe respiratory infections and failure to thrive. They are classified according to immunological phenotype into SCID with absence of T cells but presence of B cells (T-B+ SCID) or SCID with absence of both (T-B- SCID). Both of these groups include several forms, with or without natural killer (NK) cells.

      • ClinGen rates the link definitive
      • 2 GenCC submitters rate it definitive or strong

Broader groupings

  • Other Inborn Errors of Immunity

    • Inborn error of immunity

      One of 114 genes linked to it

      Inherited disorders of the immune system caused by changes in single genes, affecting how the body fights infection or regulates inflammation.

      • ClinGen rates the link definitive
      • 2 GenCC submitters rate it definitive or strong
    • Immunodeficiency Disease

      One of 170 genes linked to it

      Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

      • ClinGen rates the link definitive
      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      HSCT for SCID and severe PIDs; immunoglobulin replacement (IVIG/SCIG) for antibody deficiencies; leniolisib (Joenja, FDA 2023) for APDS; gene therapy for ADA-SCID; abatacept for CTLA4/LRBA deficiency; prophylactic antibiotics; G-CSF for CGD

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How CD70 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 19, with a bracket where CD70 sits. CD70 and 28 genes near it on chromosome 19, from 6,088,495 to 7,088,494.Chromosome 1919p13.3p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.436.2 Mb6.4 Mb6.6 Mb6.8 Mb7 MbRFX2: 5,993,164–6,199,572, reverse strandRFX2ACSBG2: 6,135,247–6,193,094, forward strandACSBG2MLLT1: 6,210,377–6,280,029, reverse strandMLLT1ACER1: 6,306,030–6,333,612, reverse strandACER1CLPP: 6,361,427–6,370,242, forward strandCLPPALKBH7: 6,372,715–6,377,261, forward strandALKBH7PSPN: 6,375,148–6,379,058, reverse strandPSPNGTF2F1: 6,379,545–6,393,981, reverse strandGTF2F1KHSRP: 6,413,102–6,424,824, reverse strandKHSRPSLC25A41: 6,426,037–6,433,779, reverse strandSLC25A23: 6,436,068–6,465,203, reverse strandSLC25A23CRB3: 6,463,777–6,467,239, forward strandCRB3DENND1C: 6,467,207–6,482,557, reverse strandDENND1CTUBB4A: 6,494,308–6,502,848, reverse strandTUBB4ATNFSF9: 6,530,985–6,535,926, forward strandTNFSF9CD70: 6,585,839–6,591,150, reverse strandCD70TNFSF14: 6,658,085–6,670,621, reverse strandTNFSF14C3: 6,677,704–6,730,562, reverse strandC3GPR108: 6,729,914–6,737,665, reverse strandGPR108TRIP10: 6,737,925–6,751,530, forward strandTRIP10SH2D3A: 6,751,899–6,768,109, reverse strandSH2D3AVAV1: 6,772,676–6,857,366, forward strandVAV1ADGRE1: 6,887,530–6,940,459, forward strandADGRE1MBD3L2B: 7,018,969–7,021,431, reverse strandMBD3L2BMBD3L5: 7,030,578–7,033,011, forward strandMBD3L5MBD3L4: 7,037,749–7,040,179, reverse strandMBD3L4MBD3L2: 7,049,321–7,051,735, forward strandMBD3L2MBD3L3: 7,056,207–7,069,665, reverse strandZNF557: 7,069,416–7,096,206, forward strandDiagram of CD70: 3 exons on the reverse strand of chromosome 19Exon 3: 6,585,839–6,586,405, 567 basesExon 2: 6,590,103–6,590,136, 34 basesExon 1: 6,590,841–6,591,150, 310 bases3215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.9 kb of the gene's 5.3 kb; 582 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CD70 gene: CD70 molecule. Retrieved 17 October 2026, from https://dantelabs.com/genes/cd70

Vancouver

Dante Labs. CD70 gene: CD70 molecule [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/cd70

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