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Gene

TRIP13

thyroid hormone receptor interactor 13

Summary

Cytogenetic location
5p15.33
Coordinates
Chromosome 5: 892,884–918,120 (GRCh38)
Exons
13 exons across 25.2 kb
Protein
432 amino acids
Inheritance
Autosomal recessive
Also known as
16E1BP
MANE Select transcript
ENST00000166345.8NM_004237.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Female Infertility

    • inherited oocyte maturation defect
      • 2 GenCC submitters rate it definitive or strong

  • Mosaic Variegated Aneuploidy Syndrome

    • Autosomal recessive

      Mosaic gains and losses of whole chromosomes with growth restriction, microcephaly and an increased risk of rhabdomyosarcoma, Wilms tumour and leukaemia.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      Childhood cancer surveillance for affected children; carriers have no expected health effects.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How TRIP13 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 5, with a bracket where TRIP13 sits. TRIP13 and 16 genes near it on chromosome 5, from 405,502 to 1,405,501.Chromosome 55p15.33p15.33p15.32p15.31p15.2p15.1p14.3p14.2p14.1p13.3p13.2p13.1p12p11q11.1q11.2q12.1q12.2q12.3q13.1q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q31.1q31.2q31.3q32q33.1q33.2q33.3q34q35.1q35.2q35.30.6 Mb0.8 Mb1 Mb1.2 Mb1.4 MbPDCD6-AHRR: 271,670–438,291, forward strandPDCD6-AHRRAHRR: 320,682–438,307, forward strandAHRREXOC3: 442,522–471,939, forward strandEXOC3SLC9A3: 470,456–524,450, reverse strandSLC9A3CEP72: 612,305–667,703, forward strandCEP72TPPP: 658,850–693,997, reverse strandTPPPZDHHC11B: 710,355–784,729, reverse strandZDHHC11BZDHHC11: 795,605–858,973, reverse strandZDHHC11BRD9: 850,291–892,838, reverse strandBRD9TRIP13: 892,884–918,120, forward strandTRIP13NKD2: 1,008,021–1,040,630, forward strandNKD2SLC12A7: 1,050,384–1,156,237, reverse strandSLC12A7SLC6A19: 1,201,595–1,225,111, forward strandSLC6A19SLC6A18: 1,225,381–1,246,189, forward strandSLC6A18TERT: 1,253,147–1,295,086, reverse strandTERTCLPTM1L: 1,316,821–1,345,100, reverse strandCLPTM1LSLC6A3: 1,392,794–1,445,514, reverse strandSLC6A3Diagram of TRIP13: 13 exons on the forward strand of chromosome 5Exon 1: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 1: 892,884–893,090, 207 basesExon 2: 894,787–894,952, 166 basesExon 3: 896,665–896,794, 130 basesExon 4: 900,494–900,549, 56 basesExon 5: 901,341–901,431, 91 basesExon 6: 904,148–904,220, 73 basesExon 7: 907,130–907,193, 64 basesExon 8: 907,988–908,074, 87 basesExon 9: 908,355–908,461, 107 basesExon 10: 911,843–911,996, 154 basesExon 11: 914,465–914,577, 113 basesExon 12: 915,904–915,973, 70 basesExon 13: 917,008–918,120, 1,113 bases124681012135′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.4 kb of the gene's 25.2 kb; 1,299 of those bases code for the protein.

How a genome test reads TRIP13

3

positions in TRIP13 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 25.2 kb of TRIP13, introns included, not only the 2.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TRIP13 gene: thyroid hormone receptor interactor 13. Retrieved 16 October 2026, from https://dantelabs.com/genes/trip13

Vancouver

Dante Labs. TRIP13 gene: thyroid hormone receptor interactor 13 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/trip13

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