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Gene

CALR

calreticulin

Summary

Cytogenetic location
19p13.13
Coordinates
Chromosome 19: 12,938,609–12,944,489 (GRCh38)
Exons
9 exons across 5.9 kb
Protein
417 amino acids
Also known as
RO, SSA, cC1qR, CRT, FLJ26680, CALR1
MANE Select transcript
ENST00000316448.10NM_004343.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads CALR yet. The test sequences your whole genome, so your data includes it all the same.

How CALR is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 19, with a bracket where CALR sits. CALR and 42 genes near it on chromosome 19, from 12,441,549 to 13,441,548.Chromosome 1919p13.13p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4312.6 Mb12.8 Mb13 Mb13.2 Mb13.4 Mb: 12,433,103–12,484,816, reverse strandZNF709: 12,461,184–12,513,854, reverse strandZNF709: 12,461,559–12,551,474, reverse strandZNF564: 12,524,903–12,551,542, reverse strandZNF564: 12,525,720–12,580,975, reverse strandZNF490: 12,575,832–12,640,098, reverse strandZNF490ZNF791: 12,610,916–12,633,840, forward strandZNF791MAN2B1: 12,643,831–12,666,762, reverse strand: 12,643,831–12,648,397, reverse strand: 12,664,828–12,669,397, reverse strandWDR83: 12,666,802–12,675,832, forward strandWDR83OS: 12,668,065–12,669,467, reverse strand: 12,668,071–12,681,834, reverse strandDHPS: 12,673,411–12,681,901, reverse strandDHPSFBXW9: 12,687,801–12,696,659, reverse strandFBXW9GNG14: 12,687,998–12,688,422, forward strandGNG14TNPO2: 12,699,111–12,724,011, reverse strandTNPO2TRIR: 12,730,640–12,734,747, reverse strandTRIRGET3: 12,737,139–12,748,325, forward strandGET3BEST2: 12,751,673–12,758,458, forward strandBEST2HOOK2: 12,762,640–12,872,740, reverse strandHOOK2JUNB: 12,791,486–12,793,315, forward strandPRDX2: 12,796,817–12,801,882, reverse strandTHSD8: 12,802,031–12,813,581, forward strandRNASEH2A: 12,806,505–12,813,644, forward strandRNASEH2ARTBDN: 12,825,477–12,838,362, reverse strandRTBDNMAST1: 12,833,860–12,874,952, forward strandMAST1DNASE2: 12,875,209–12,881,595, reverse strandKLF1: 12,884,405–12,887,201, reverse strandGCDH: 12,891,128–12,915,261, forward strandSYCE2: 12,898,786–12,919,306, reverse strandFARSA: 12,921,138–12,934,037, reverse strandFARSACALR: 12,938,609–12,944,489, forward strandCALRRAD23A: 12,945,716–12,953,646, forward strandRAD23AGADD45GIP1: 12,950,701–12,957,333, reverse strandGADD45GIP1DAND5: 12,965,159–12,974,760, forward strandNFIX: 12,995,401–13,098,796, forward strandNFIXLYL1: 13,099,028–13,103,188, reverse strandLYL1TRMT1: 13,104,899–13,117,567, reverse strandTRMT1NACC1: 13,116,468–13,141,147, forward strandNACC1STX10: 13,144,058–13,150,383, reverse strandSTX10IER2: 13,150,403–13,156,981, forward strandIER2CACNA1A: 13,206,442–13,624,489, reverse strandCACNA1ADiagram of CALR: 9 exons on the forward strand of chromosome 19Exon 9: 2 known disease-causing sitesExon 1: 12,938,609–12,938,770, 162 basesExon 2: 12,939,134–12,939,235, 102 basesExon 3: 12,939,428–12,939,631, 204 basesExon 4: 12,940,053–12,940,147, 95 basesExon 5: 12,940,243–12,940,452, 210 basesExon 6: 12,940,541–12,940,654, 114 basesExon 7: 12,940,744–12,940,887, 144 basesExon 8: 12,943,537–12,943,629, 93 basesExon 9: 12,943,713–12,944,489, 777 bases1234567895′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.9 kb of the gene's 5.9 kb; 1,254 of those bases code for the protein.

How a genome test reads CALR

2

positions in CALR where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 5.9 kb of CALR, introns included, not only the 1.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CALR gene: calreticulin. Retrieved 16 October 2026, from https://dantelabs.com/genes/calr

Vancouver

Dante Labs. CALR gene: calreticulin [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/calr

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