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Gene

MYD88

MYD88 innate immune signal transduction adaptor

Summary

Cytogenetic location
3p22.2
Coordinates
Chromosome 3: 38,138,661–38,143,022 (GRCh38)
Exons
5 exons across 4.4 kb
Protein
296 amino acids
MANE Select transcript
ENST00000650905.2NM_002468.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Other Inborn Errors of Immunity

      • Immunodeficiency Disease

        One of 170 genes linked to it

        Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

        • 2 GenCC submitters rate it definitive or strong
        What knowing changes

        HSCT for SCID and severe PIDs; immunoglobulin replacement (IVIG/SCIG) for antibody deficiencies; leniolisib (Joenja, FDA 2023) for APDS; gene therapy for ADA-SCID; abatacept for CTLA4/LRBA deficiency; prophylactic antibiotics; G-CSF for CGD

    How MYD88 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    Chromosome 3, with a bracket where MYD88 sits. MYD88 and 13 genes near it on chromosome 3, from 37,640,842 to 38,640,841.Chromosome 33p22.2p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q2937.8 Mb38 Mb38.2 Mb38.4 Mb38.6 MbITGA9: 37,452,090–37,823,622, forward strandITGA9CTDSPL: 37,861,832–37,984,469, forward strandCTDSPLVILL: 37,987,960–38,007,535, forward strandVILLPLCD1: 38,007,496–38,029,680, reverse strandPLCD1DLEC1: 38,039,190–38,124,025, forward strandDLEC1ACAA1: 38,103,129–38,137,647, reverse strandACAA1MYD88: 38,138,661–38,143,022, forward strandMYD88OXSR1: 38,165,089–38,255,487, forward strandOXSR1SLC22A13: 38,265,812–38,278,757, forward strandSLC22A13SLC22A14: 38,282,294–38,318,575, forward strandSLC22A14XYLB: 38,346,743–38,428,434, forward strandXYLBACVR2B: 38,453,843–38,493,142, forward strandACVR2BEXOG: 38,496,127–38,542,242, forward strandEXOGSCN5A: 38,548,057–38,649,743, reverse strandSCN5ADiagram of MYD88: 5 exons on the forward strand of chromosome 3Exon 1: 4 known disease-causing sitesExon 3: 1 known disease-causing siteExon 1: 38,138,661–38,139,028, 368 basesExon 2: 38,139,864–38,139,998, 135 basesExon 3: 38,140,388–38,140,568, 181 basesExon 4: 38,140,757–38,140,848, 92 basesExon 5: 38,141,132–38,143,022, 1,891 bases123455′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 2.7 kb of the gene's 4.4 kb; 891 of those bases code for the protein.

    How a genome test reads MYD88

    6

    positions in MYD88 where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 4.4 kb of MYD88, introns included, not only the 2.7 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). MYD88 gene: MYD88 innate immune signal transduction adaptor. Retrieved 17 October 2026, from https://dantelabs.com/genes/myd88

    Vancouver

    Dante Labs. MYD88 gene: MYD88 innate immune signal transduction adaptor [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/myd88

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