Gene
TLR4
toll like receptor 4
- HGNC 11850(opens in a new tab)
- Ensembl gene ENSG00000136869(opens in a new tab)
- NCBI Gene 7099(opens in a new tab)
Summary
- Cytogenetic location
- 9q33.1
- Coordinates
- Chromosome 9: 117,704,403–117,724,735 (GRCh38)
- Exons
- 3 exons across 20.3 kb
- Protein
- 839 amino acids
- Also known as
- hToll, CD284, TLR-4, ARMD10
- MANE Select transcript
- ENST00000355622.8NM_138554.5
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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How TLR4 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 12.7 kb of the gene's 20.3 kb; 2,520 of those bases code for the protein.
Traits linked to TLR4
The Human Phenotype Ontology lists these as features of the rare conditions TLR4 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the immune system
- Meningitis
- Acne
- Erythema nodosum
- Immunologic hypersensitivity
- Increased inflammatory response
- Pimple
- Brain inflammation
- Muscle inflammation
Show 1 more trait
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
Cite this page
Dante Labs. (n.d.). TLR4 gene: toll like receptor 4. Retrieved 16 October 2026, from https://dantelabs.com/genes/tlr4
Dante Labs. TLR4 gene: toll like receptor 4 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tlr4
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