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Gene

TNFRSF13B

TNF receptor superfamily member 13B

Summary

Cytogenetic location
17p11.2
Coordinates
Chromosome 17: 16,939,081–16,972,118 (GRCh38)
Exons
5 exons across 33 kb
Protein
293 amino acids
Also known as
TACI, CD267, IGAD2
MANE Select transcript
ENST00000261652.7NM_012452.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Common Variable Immunodeficiency (Monogenic CVID)

    • Common variable immunodeficiency

      Low IgG with low IgA and/or IgM and poor vaccine responses; single-gene forms include NFKB1, NFKB2, ICOS, CD19, CD81, CR2, IKZF1, IRF2BP2, SEC61A1 and TNFRSF13B (TACI).

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      Immunoglobulin replacement and early treatment of infections are standard; a genetic cause can guide monitoring for autoimmunity, lymphoma and lung disease, and some forms (such as LRBA deficiency) respond to targeted therapy.

Broader groupings

  • Other Inborn Errors of Immunity

    • Inborn error of immunity

      One of 114 genes linked to it

      Inherited disorders of the immune system caused by changes in single genes, affecting how the body fights infection or regulates inflammation.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
    • Immunodeficiency Disease

      One of 170 genes linked to it

      Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

      • ClinGen rates the link definitive
      • 5 GenCC submitters rate it definitive or strong
      What knowing changes

      HSCT for SCID and severe PIDs; immunoglobulin replacement (IVIG/SCIG) for antibody deficiencies; leniolisib (Joenja, FDA 2023) for APDS; gene therapy for ADA-SCID; abatacept for CTLA4/LRBA deficiency; prophylactic antibiotics; G-CSF for CGD

How TNFRSF13B is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 17, with a bracket where TNFRSF13B sits. TNFRSF13B and 11 genes near it on chromosome 17, from 16,455,600 to 17,455,599.Chromosome 1717p11.2p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.316.6 Mb16.8 Mb17 Mb17.2 Mb17.4 MbLRRC75A: 16,441,493–16,492,237, reverse strandLRRC75AZNF287: 16,546,954–16,569,218, reverse strandZNF287ZNF624: 16,620,734–16,653,860, reverse strandZNF624CCDC144A: 16,689,537–16,777,974, forward strandCCDC144A: 16,690,261–16,804,453, forward strandTNFRSF13B: 16,939,081–16,972,118, reverse strandTNFRSF13BMPRIP: 17,042,381–17,217,679, forward strandMPRIPPLD6: 17,200,622–17,206,369, reverse strandPLD6: 17,202,649–17,237,185, reverse strandFLCN: 17,212,200–17,237,326, reverse strandFLCNCOPS3: 17,244,686–17,281,311, reverse strandCOPS3NT5M: 17,303,316–17,347,663, forward strandNT5MDiagram of TNFRSF13B: 5 exons on the reverse strand of chromosome 17Exon 5: 1 known disease-causing siteExon 4: 9 known disease-causing sitesExon 3: 15 known disease-causing sitesExon 2: 7 known disease-causing sitesExon 1: 2 known disease-causing sitesExon 5: 16,939,081–16,939,797, 717 basesExon 4: 16,940,326–16,940,511, 186 basesExon 3: 16,948,738–16,948,983, 246 basesExon 2: 16,952,446–16,952,583, 138 basesExon 1: 16,972,015–16,972,118, 104 bases543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.4 kb of the gene's 33 kb; 882 of those bases code for the protein.

How a genome test reads TNFRSF13B

38

positions in TNFRSF13B where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 33 kb of TNFRSF13B, introns included, not only the 1.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TNFRSF13B gene: TNF receptor superfamily member 13B. Retrieved 16 October 2026, from https://dantelabs.com/genes/tnfrsf13b

Vancouver

Dante Labs. TNFRSF13B gene: TNF receptor superfamily member 13B [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tnfrsf13b

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