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Gene

NPR2

natriuretic peptide receptor 2

Summary

Cytogenetic location
9p13.3
Coordinates
Chromosome 9: 35,791,591–35,809,731 (GRCh38)
Exons
22 exons across 18.1 kb
Protein
1,047 amino acids
Also known as
GUCY2B, ANPb, GC-B
Previous symbols
ANPRB, NPRB, AMDM
MANE Select transcript
ENST00000342694.7NM_003995.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads NPR2 yet. The test sequences your whole genome, so your data includes it all the same.

How NPR2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 9, with a bracket where NPR2 sits. NPR2 and 31 genes near it on chromosome 9, from 35,300,661 to 36,300,660.Chromosome 99p13.3p24.3p24.2p24.1p23p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q13q21.11q21.12q21.13q21.2q21.31q21.32q21.33q22.1q22.2q22.31q22.32q22.33q31.1q31.2q31.3q32q33.1q33.2q33.3q34.11q34.12q34.13q34.2q34.335.4 Mb35.6 Mb35.8 Mb36 Mb36.2 MbUNC13B: 35,161,829–35,405,339, forward strandUNC13BRUSC2: 35,489,670–35,562,266, forward strandRUSC2CIMIP2B: 35,561,831–35,563,914, reverse strandCIMIP2BTESK1: 35,605,235–35,610,328, forward strandTESK1CD72: 35,609,965–35,646,810, reverse strandCD72SIT1: 35,649,288–35,650,970, reverse strandRMRP: 35,657,750–35,658,019, reverse strandCCDC107: 35,658,277–35,661,524, forward strandARHGEF39: 35,658,874–35,675,866, reverse strandARHGEF39CA9: 35,673,898–35,681,159, forward strandCA9TPM2: 35,681,992–35,691,116, reverse strandTPM2TLN1: 35,696,925–35,732,212, reverse strandCREB3: 35,732,296–35,738,887, forward strandCREB3GBA2: 35,734,577–35,749,986, reverse strandGBA2RGP1: 35,748,613–35,759,600, forward strandRGP1MSMP: 35,752,990–35,756,613, reverse strandMSMPNPR2: 35,791,591–35,809,731, forward strandNPR2SPAG8: 35,808,045–35,812,272, reverse strandSPAG8HINT2: 35,812,960–35,815,354, reverse strandHINT2: 35,812,960–35,828,732, reverse strandTMEM8B: 35,814,451–35,865,518, forward strandFAM221B: 35,816,391–35,828,747, reverse strandOR13J1: 35,869,463–35,870,401, reverse strandOR13J1HRCT1: 35,906,202–35,907,136, forward strandHRCT1SPAAR: 35,909,488–35,937,153, forward strandSPAAROR2S2: 35,957,108–35,958,154, reverse strandOR2S2OR13C7: 36,002,909–36,003,867, reverse strandOR13C7RECK: 36,036,896–36,124,457, forward strandRECKGLIPR2: 36,136,417–36,163,913, forward strandGLIPR2CCIN: 36,165,751–36,172,384, forward strandCCINCLTA: 36,190,856–36,304,781, forward strandCLTAGNE: 36,214,441–36,277,042, reverse strandGNEDiagram of NPR2: 22 exons on the forward strand of chromosome 9Exon 1: 9 known disease-causing sitesExon 2: 4 known disease-causing sitesExon 3: 1 known disease-causing siteExon 4: 4 known disease-causing sitesExon 5: 3 known disease-causing sitesExon 6: 3 known disease-causing sitesExon 7: 2 known disease-causing sitesExon 8: 1 known disease-causing siteExon 9: 2 known disease-causing sitesExon 10: 3 known disease-causing sitesExon 11: 3 known disease-causing sitesExon 12: 1 known disease-causing siteExon 13: 1 known disease-causing siteExon 14: 6 known disease-causing sitesExon 15: 7 known disease-causing sitesExon 16: 2 known disease-causing sitesExon 17: 4 known disease-causing sitesExon 19: 6 known disease-causing sitesExon 20: 4 known disease-causing sitesExon 1: 35,791,591–35,793,075, 1,485 basesExon 2: 35,793,898–35,794,103, 206 basesExon 3: 35,799,618–35,799,731, 114 basesExon 4: 35,800,022–35,800,157, 136 basesExon 5: 35,800,389–35,800,483, 95 basesExon 6: 35,800,709–35,800,841, 133 basesExon 7: 35,801,070–35,801,154, 85 basesExon 8: 35,801,643–35,801,763, 121 basesExon 9: 35,801,926–35,802,000, 75 basesExon 10: 35,802,206–35,802,283, 78 basesExon 11: 35,802,503–35,802,607, 105 basesExon 12: 35,802,732–35,802,803, 72 basesExon 13: 35,805,511–35,805,670, 160 basesExon 14: 35,805,830–35,805,985, 156 basesExon 15: 35,806,065–35,806,233, 169 basesExon 16: 35,806,392–35,806,538, 147 basesExon 17: 35,807,023–35,807,146, 124 basesExon 18: 35,807,330–35,807,398, 69 basesExon 19: 35,808,509–35,808,683, 175 basesExon 20: 35,808,755–35,808,853, 99 basesExon 21: 35,809,156–35,809,247, 92 basesExon 22: 35,809,380–35,809,731, 352 bases12468101214161820225′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.2 kb of the gene's 18.1 kb; 3,144 of those bases code for the protein.

How a genome test reads NPR2

76

positions in NPR2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 18.1 kb of NPR2, introns included, not only the 4.2 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). NPR2 gene: natriuretic peptide receptor 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/npr2

Vancouver

Dante Labs. NPR2 gene: natriuretic peptide receptor 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/npr2

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