Trait
Joint contracture
A limitation in the passive range of motion of a joint resulting from loss of elasticity in the periarticular tissues owing to structural changes of non-bony tissues, such as muscles, tendons, ligaments, joint capsules or skin. A contracture prevents movement of the associated body part.
Summary
- Also called
- Contracture
- Body system
- Abnormality of the musculoskeletal system
Reference genomeGRCh38hg38
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Get my Genome Test66 genes linked to Joint contracture
Changes in these genes cause rare conditions in which Joint contracture is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ACER3alkaline ceramidase 3 | Always | In 1 condition |
| ACTA1actin alpha 1, skeletal muscle | Always | In 1 condition |
| ALG1ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase | Always | In 1 condition |
| B3GALT6beta-1,3-galactosyltransferase 6 | Always | In 1 condition |
| BRAT1BRCA1 associated ATM activator 1 | Always | In 1 condition |
| ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit | Always | In 1 condition |
| ERLIN2ER lipid raft associated 2 | Always | In 1 condition |
| FCSKfucose kinase | Always | In 1 condition |
| FLVCR1FLVCR choline and heme transporter 1 | Always | In 1 condition |
| HSPB8heat shock protein family B (small) member 8 | Always | In 1 condition |
| KDM2Blysine demethylase 2B | Always | In 1 condition |
| LIASlipoic acid synthetase | Always | In 1 condition |
| LMNAlamin A/C | Always | In 1 condition |
| NALCNsodium leak channel, non-selective | Always | In 1 condition |
| POLD1DNA polymerase delta 1, catalytic subunit | Always | In 1 condition |
| SNUPNsnurportin 1 | Always | In 1 condition |
| SPTSSAserine palmitoyltransferase small subunit A | Always | In 1 condition |
| TPM2tropomyosin 2 | Always | In 1 condition |
| TTNtitin | Always | In 1 condition |
| AIMP1aminoacyl tRNA synthetase complex interacting multifunctional protein 1 | Very often (80–99%) | In 1 condition |
| FAM111BFAM111 trypsin like peptidase B | Very often (80–99%) | In 1 condition |
| FLVCR2FLVCR choline and putative heme transporter 2 | Very often (80–99%) | In 1 condition |
| NKX6-2NK6 homeobox 2 | Very often (80–99%) | In 1 condition |
| PRUNE1prune exopolyphosphatase 1 | Very often (80–99%) | In 1 condition |
| WDR45BWD repeat domain 45B | Very often (80–99%) | In 1 condition |
| ADAMTSL2ADAMTS like 2 | Often (30–79%) | In 1 condition |
| ATP6V1AATPase H+ transporting V1 subunit A | Often (30–79%) | In 1 condition |
| BGNbiglycan | Often (30–79%) | In 1 condition |
| BUD13BUD13 spliceosome associated protein | Often (30–79%) | In 1 condition |
| COG3component of oligomeric golgi complex 3 | Often (30–79%) | In 1 condition |
| COL6A3collagen type VI alpha 3 chain | Often (30–79%) | In 1 condition |
| ELOVL4ELOVL fatty acid elongase 4 | Often (30–79%) | In 1 condition |
| FAM177A1family with sequence similarity 177 member A1 | Often (30–79%) | In 1 condition |
| FBN1fibrillin 1 | Often (30–79%) | In 1 condition |
| FUT8fucosyltransferase 8 | Often (30–79%) | In 1 condition |
| GFM2GTP dependent ribosome recycling factor mitochondrial 2 | Often (30–79%) | In 1 condition |
| HIKESHIheat shock protein nuclear import factor hikeshi | Often (30–79%) | In 1 condition |
| IBA57iron-sulfur cluster assembly factor IBA57 | Often (30–79%) | In 1 condition |
| KLHL7kelch like family member 7 | Often (30–79%) | In 1 condition |
| LTBP3latent transforming growth factor beta binding protein 3 | Often (30–79%) | In 1 condition |
Show 26 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| MRPS34mitochondrial ribosomal protein S34 | Often (30–79%) | In 1 condition |
| NCAPG2non-SMC condensin II complex subunit G2 | Often (30–79%) | In 1 condition |
| PGBD5piggyBac transposable element derived 5 | Often (30–79%) | In 1 condition |
| SCARF2scavenger receptor class F member 2 | Often (30–79%) | In 1 condition |
| SLC26A2solute carrier family 26 member 2 | Often (30–79%) | In 1 condition |
| STAT4signal transducer and activator of transcription 4 | Often (30–79%) | In 1 condition |
| STIM1stromal interaction molecule 1 | Often (30–79%) | In 1 condition |
| TBCKTBC1 domain containing kinase | Often (30–79%) | In 1 condition |
| TOR1AIP1torsin 1A interacting protein 1 | Often (30–79%) | In 1 condition |
| TRIP4thyroid hormone receptor interactor 4 | Often (30–79%) | In 1 condition |
| ATP6V1E1ATPase H+ transporting V1 subunit E1 | Sometimes (5–29%) | In 1 condition |
| COASYCoenzyme A synthase | Sometimes (5–29%) | In 1 condition |
| EXOSC8exosome component 8 | Sometimes (5–29%) | In 1 condition |
| FLNCfilamin C | Sometimes (5–29%) | In 1 condition |
| GRIA4glutamate ionotropic receptor AMPA type subunit 4 | Sometimes (5–29%) | In 1 condition |
| GSCgoosecoid homeobox | Sometimes (5–29%) | In 1 condition |
| NACC1nucleus accumbens associated 1 | Sometimes (5–29%) | In 1 condition |
| PCNAproliferating cell nuclear antigen | Sometimes (5–29%) | In 1 condition |
| PDGFRBplatelet derived growth factor receptor beta | Sometimes (5–29%) | In 1 condition |
| POGZpogo transposable element derived with ZNF domain | Sometimes (5–29%) | In 1 condition |
| POLR1ARNA polymerase I subunit A | Sometimes (5–29%) | In 1 condition |
| PTH1Rparathyroid hormone 1 receptor | Sometimes (5–29%) | In 1 condition |
| TNPO3transportin 3 | Sometimes (5–29%) | In 1 condition |
| TRAF7TNF receptor associated factor 7 | Sometimes (5–29%) | In 1 condition |
| DDCdopa decarboxylase | Rarely (1–4%) | In 1 condition |
| GMPPBGDP-mannose pyrophosphorylase B | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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