Skip to content
Use your HSA or FSA funds

Gene

LMOD3

leiomodin 3

Summary

Cytogenetic location
3p14.1
Coordinates
Chromosome 3: 69,106,065–69,122,595 (GRCh38)
Exons
3 exons across 16.5 kb
Protein
560 amino acids
MANE Select transcript
ENST00000420581.7NM_198271.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Congenital Myopathies

    • Nemaline myopathy

      A congenital myopathy defined by rod-shaped structures in muscle fibers, most often caused by NEB or ACTA1 variants.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong

How LMOD3 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 3, with a bracket where LMOD3 sits. LMOD3 and 6 genes near it on chromosome 3, from 68,614,330 to 69,614,329.Chromosome 33p14.1p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q2968.8 Mb69 Mb69.2 Mb69.4 Mb69.6 MbTAFA4: 68,731,593–68,953,297, reverse strandTAFA4EOGT: 68,975,217–69,013,719, reverse strandEOGTTMF1: 69,019,827–69,052,382, reverse strandTMF1UBA3: 69,053,972–69,080,408, reverse strandUBA3ARL6IP5: 69,084,785–69,106,092, forward strandARL6IP5LMOD3: 69,106,065–69,122,595, reverse strandLMOD3FRMD4B: 69,168,782–69,542,583, reverse strandFRMD4BDiagram of LMOD3: 3 exons on the reverse strand of chromosome 3Exon 2: 32 known disease-causing sitesExon 1: 9 known disease-causing sitesExon 3: 69,106,065–69,109,121, 3,057 basesExon 2: 69,118,699–69,120,060, 1,362 basesExon 1: 69,122,093–69,122,595, 503 bases3215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.9 kb of the gene's 16.5 kb; 1,683 of those bases code for the protein.

How a genome test reads LMOD3

41

positions in LMOD3 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 16.5 kb of LMOD3, introns included, not only the 4.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). LMOD3 gene: leiomodin 3. Retrieved 17 October 2026, from https://dantelabs.com/genes/lmod3

Vancouver

Dante Labs. LMOD3 gene: leiomodin 3 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/lmod3

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test