Trait

Decreased muscle movement

Clinical name: Hypokinesia

Abnormally diminished motor activity. In contrast to paralysis, hypokinesia is not characterized by a lack of motor strength, but rather by a poverty of movement. The typical habitual movements (e.g., folding the arms, crossing the legs) are reduced in frequency.

HPO HP:0002375

Also called: Decreased spontaneous movement, Decreased spontaneous movements
Body system: Abnormality of the nervous system

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60 genes linked to Decreased muscle movement

Changes in these genes cause rare conditions in which Decreased muscle movement is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
ATP7BATPase copper transporting beta	Always	In 1 condition
MRPS16mitochondrial ribosomal protein S16	Always	In 1 condition
PET117PET117 cytochrome c oxidase chaperone	Always	In 1 condition
PRKNparkin RBR E3 ubiquitin protein ligase	Always	In 1 condition
RFC4replication factor C subunit 4	Always	In 1 condition
TRIM63tripartite motif containing 63	Always	In 1 condition
DOK7docking protein 7	Very often (80–99%)	In 1 condition
GLDNgliomedin	Very often (80–99%)	In 1 condition
KIF21Akinesin family member 21A	Very often (80–99%)	In 1 condition
LAMA2laminin subunit alpha 2	Very often (80–99%)	In 1 condition
MAGEL2MAGE family member L2	Very often (80–99%)	In 1 condition
MUSKmuscle associated receptor tyrosine kinase	Very often (80–99%)	In 1 condition
MYOD1myogenic differentiation 1	Very often (80–99%)	In 1 condition
NUP88nucleoporin 88	Very often (80–99%)	In 1 condition
RAPSNreceptor associated protein of the synapse	Very often (80–99%)	In 1 condition
SLC18A3solute carrier family 18 member A3	Very often (80–99%)	In 1 condition
TUBA1Atubulin alpha 1a	Very often (80–99%)	In 1 condition
WWOXWW domain containing oxidoreductase	Very often (80–99%)	In 1 condition
ACTA1actin alpha 1, skeletal muscle	Often (30–79%)	In 3 conditions
AIFM1apoptosis inducing factor mitochondria associated 1	Often (30–79%)	In 2 conditions
ATP13A2ATPase cation transporting 13A2	Often (30–79%)	In 1 condition
FRRS1Lferric chelate reductase 1 like	Often (30–79%)	In 1 condition
GFM1G elongation factor mitochondrial 1	Often (30–79%)	In 1 condition
HTThuntingtin	Often (30–79%)	In 1 condition
KLHL40kelch like family member 40	Often (30–79%)	In 1 condition
KLHL41kelch like family member 41	Often (30–79%)	In 3 conditions
LMOD3leiomodin 3	Often (30–79%)	In 2 conditions
NEBnebulin	Often (30–79%)	In 3 conditions
SLC16A2solute carrier family 16 member 2	Often (30–79%)	In 1 condition
SLC2A3solute carrier family 2 member 3	Often (30–79%)	In 1 condition
SLC6A3solute carrier family 6 member 3	Often (30–79%)	In 1 condition
THtyrosine hydroxylase	Often (30–79%)	In 2 conditions
TPM3tropomyosin 3	Often (30–79%)	In 1 condition
TSPOAP1TSPO associated protein 1	Often (30–79%)	In 1 condition
WARS2tryptophanyl tRNA synthetase 2, mitochondrial	Often (30–79%)	In 1 condition
ALG11ALG11 alpha-1,2-mannosyltransferase	Sometimes (5–29%)	In 1 condition
CFL2cofilin 2	Sometimes (5–29%)	In 1 condition
CLTCclathrin heavy chain	Sometimes (5–29%)	In 1 condition
DDCdopa decarboxylase	Sometimes (5–29%)	In 1 condition
LGI3leucine rich repeat LGI family member 3	Sometimes (5–29%)	In 1 condition

Show 20 more genes

Gene	How often it is seen	Conditions
POLGDNA polymerase gamma, catalytic subunit	Sometimes (5–29%)	In 1 condition
POLG2DNA polymerase gamma 2, accessory subunit	Sometimes (5–29%)	In 1 condition
PPP2R2Bprotein phosphatase 2 regulatory subunit Bbeta	Sometimes (5–29%)	In 1 condition
PRNPprion protein (Kanno blood group)	Sometimes (5–29%)	In 1 condition
RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B	Sometimes (5–29%)	In 1 condition
SLC25A4solute carrier family 25 member 4	Sometimes (5–29%)	In 1 condition
SLC39A14solute carrier family 39 member 14	Sometimes (5–29%)	In 1 condition
TPM2tropomyosin 2	Sometimes (5–29%)	In 1 condition
TWNKtwinkle mtDNA helicase	Sometimes (5–29%)	In 1 condition
DPM2dolichyl-phosphate mannosyltransferase subunit 2, regulatory	Not recorded	In 1 condition
GBA1glucosylceramidase beta 1	Not recorded	In 1 condition
GLRA1glycine receptor alpha 1	Not recorded	In 1 condition
GPHNgephyrin	Not recorded	In 1 condition
LAMP2lysosome associated membrane protein 2	Not recorded	In 1 condition
MPZmyelin protein zero	Not recorded	In 1 condition
MTM1myotubularin 1	Not recorded	In 1 condition
PAM16presequence translocase associated motor 16	Not recorded	In 1 condition
PDE8Bphosphodiesterase 8B	Not recorded	In 1 condition
SLC52A2solute carrier family 52 member 2	Not recorded	In 1 condition
SNCAsynuclein alpha	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Diminished movement

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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