Trait
Reduced spine movement
Clinical name: Spinal rigidity
Reduced ability to move the vertebral column with a resulting limitation of neck and trunk flexion.
Summary
- Also called
- Rigid spine
- Body system
- Abnormality of the musculoskeletal system
Reference genomeGRCh38hg38
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Get my Genome Test57 genes linked to Reduced spine movement
Changes in these genes cause rare conditions in which Reduced spine movement is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| COL6A1collagen type VI alpha 1 chain | Always | In 3 conditions |
| FHL1four and a half LIM domains 1 | Always | In 4 conditions |
| FILIP1filamin A interacting protein 1 | Always | In 1 condition |
| HMGCS13-hydroxy-3-methylglutaryl-CoA synthase 1 | Always | In 1 condition |
| HSPB8heat shock protein family B (small) member 8 | Always | In 1 condition |
| KYkyphoscoliosis peptidase | Always | In 1 condition |
| LMNAlamin A/C | Always | In 5 conditions |
| MYMKmyomaker, myoblast fusion factor | Always | In 1 condition |
| ORAI1ORAI calcium release-activated calcium modulator 1 | Always | In 1 condition |
| TNNT1troponin T1, slow skeletal type | Always | In 1 condition |
| TRIM63tripartite motif containing 63 | Always | In 1 condition |
| ACTA1actin alpha 1, skeletal muscle | Very often (80–99%) | In 4 conditions |
| ACVR1activin A receptor type 1 | Very often (80–99%) | In 1 condition |
| COL12A1collagen type XII alpha 1 chain | Very often (80–99%) | In 2 conditions |
| COL6A2collagen type VI alpha 2 chain | Very often (80–99%) | In 5 conditions |
| COL6A3collagen type VI alpha 3 chain | Very often (80–99%) | In 2 conditions |
| SELENONselenoprotein N | Very often (80–99%) | In 3 conditions |
| ADAMTS15ADAM metallopeptidase with thrombospondin type 1 motif 15 | Often (30–79%) | In 1 condition |
| BAG3BAG cochaperone 3 | Often (30–79%) | In 1 condition |
| CAPN3calpain 3 | Often (30–79%) | In 1 condition |
| COL13A1collagen type XIII alpha 1 chain | Often (30–79%) | In 1 condition |
| DNAJB4DnaJ heat shock protein family (Hsp40) member B4 | Often (30–79%) | In 1 condition |
| EMDemerin | Often (30–79%) | In 1 condition |
| HSPG2heparan sulfate proteoglycan 2 | Often (30–79%) | In 1 condition |
| JAG2jagged canonical Notch ligand 2 | Often (30–79%) | In 1 condition |
| KBTBD13kelch repeat and BTB domain containing 13 | Often (30–79%) | In 1 condition |
| KLHL41kelch like family member 41 | Often (30–79%) | In 2 conditions |
| MGME1mitochondrial genome maintenance exonuclease 1 | Often (30–79%) | In 2 conditions |
| MYBPC1myosin binding protein C1 | Often (30–79%) | In 1 condition |
| MYH7myosin heavy chain 7 | Often (30–79%) | In 1 condition |
| MYPNmyopalladin | Often (30–79%) | In 1 condition |
| NEBnebulin | Often (30–79%) | In 3 conditions |
| SYNE1spectrin repeat containing nuclear envelope protein 1 | Often (30–79%) | In 1 condition |
| SYNE2spectrin repeat containing nuclear envelope protein 2 | Often (30–79%) | In 1 condition |
| TMEM43transmembrane protein 43 | Often (30–79%) | In 1 condition |
| TOR1AIP1torsin 1A interacting protein 1 | Often (30–79%) | In 1 condition |
| TPM2tropomyosin 2 | Often (30–79%) | In 2 conditions |
| TPM3tropomyosin 3 | Often (30–79%) | In 1 condition |
| TRIP4thyroid hormone receptor interactor 4 | Often (30–79%) | In 2 conditions |
| TTNtitin | Often (30–79%) | In 1 condition |
Show 17 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| CFL2cofilin 2 | Sometimes (5–29%) | In 1 condition |
| COL2A1collagen type II alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| ERLIN2ER lipid raft associated 2 | Sometimes (5–29%) | In 1 condition |
| INPP5Kinositol polyphosphate-5-phosphatase K | Sometimes (5–29%) | In 1 condition |
| JPH1junctophilin 1 | Sometimes (5–29%) | In 1 condition |
| LMOD3leiomodin 3 | Sometimes (5–29%) | In 1 condition |
| POMT1protein O-mannosyltransferase 1 | Sometimes (5–29%) | In 2 conditions |
| PYROXD1pyridine nucleotide-disulphide oxidoreductase domain 1 | Sometimes (5–29%) | In 1 condition |
| SCN4Asodium voltage-gated channel alpha subunit 4 | Sometimes (5–29%) | In 2 conditions |
| SNUPNsnurportin 1 | Sometimes (5–29%) | In 1 condition |
| TNPO3transportin 3 | Sometimes (5–29%) | In 1 condition |
| DESdesmin | Rarely (1–4%) | In 1 condition |
| DYSFdysferlin | Rarely (1–4%) | In 1 condition |
| CAVIN1caveolae associated protein 1 | Not recorded | In 1 condition |
| FKTNfukutin | Not recorded | In 1 condition |
| POMT2protein O-mannosyltransferase 2 | Not recorded | In 1 condition |
| VAMP1vesicle associated membrane protein 1 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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