Trait

Muscle weakness between ribs

Clinical name: Intercostal muscle weakness

Lack of strength of the intercostal muscles, i.e., of the muscle groups running along the ribs that create and move the chest wall.

HPO HP:0004878

Body system: Abnormality of the musculoskeletal system Abnormality of the respiratory system

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11 condition reports read genes linked to this trait

Dante Labs condition reports look at the genes behind groups of inherited conditions, read from one whole-genome test. Each page says which conditions and genes a report covers, how it is read and what it cannot tell you.

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11 genes linked to Muscle weakness between ribs

Changes in these genes cause rare conditions in which Muscle weakness between ribs is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
VRK1VRK serine/threonine kinase 1	Often (30–79%)	In 1 condition
ACTA1actin alpha 1, skeletal muscle	Sometimes (5–29%)	In 1 condition
HACD13-hydroxyacyl-CoA dehydratase 1	Sometimes (5–29%)	In 1 condition
ITGA7integrin subunit alpha 7	Sometimes (5–29%)	In 1 condition
LAMA2laminin subunit alpha 2	Sometimes (5–29%)	In 1 condition
MAP3K20mitogen-activated protein kinase kinase kinase 20	Sometimes (5–29%)	In 1 condition
MYL2myosin light chain 2	Sometimes (5–29%)	In 1 condition
SELENONselenoprotein N	Sometimes (5–29%)	In 1 condition
TPM2tropomyosin 2	Sometimes (5–29%)	In 1 condition
TPM3tropomyosin 3	Sometimes (5–29%)	In 1 condition
TRPV4transient receptor potential cation channel subfamily V member 4	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Muscle weakness Respiratory function loss

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.19-9814e911.

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