AtlasWho We HelpOur ScienceProductsOutcomes
Log InAskSequence your genome↗
Trait
Lower limb amyotrophy
Muscular atrophy affecting the lower limb.
Summary
- Body system
- Abnormality of the musculoskeletal system
AtlasWho We HelpOur ScienceProductsOutcomes
Log InAskSequence your genome↗
This page as data
Add .json to the page's address, or ask for application/json, to read it as JSON.
library(jsonlite)
url <- "https://dantelabs.com/traits/lower-limb-amyotrophy.json"
page <- fromJSON(url)
page$trait$nameLower limb amyotrophyHP:0007210
AtlasWho We HelpOur ScienceProductsOutcomes
Log InAskSequence your genome↗
Read the genes linked to Lower limb amyotrophy, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test31 condition reports read genes linked to this trait
Dante Labs condition reports look at the genes behind groups of inherited conditions, read from one whole-genome test. Each page says which conditions and genes a report covers, how it is read and what it cannot tell you.
- Charcot-Marie-Tooth DiseaseReads 11 of these genesMFN2NEFHCOQ7MORC2HK1NDRG1About this report →
- Rare Hereditary Peripheral NeuropathiesReads 17 of these genesMFN2MTRFRNEFHPDXKTFGCOQ7About this report →
- CYP7B1-Related Spastic Paraplegia and Liver DiseaseReads 1 of these genesCYP7B1About this report →
- Danon DiseaseReads 1 of these genesLAMP2About this report →
Show 27 more reports
- Siddiqi SyndromeReads 1 of these genesFITM2About this report →
- Hereditary Spastic ParaplegiaReads 7 of these genesTFGPLP1CYP7B1FARS2KIF1ARTN2About this report →
- Distal MyopathiesReads 3 of these genesADSS1ANO5GNEAbout this report →
- Inherited Neurodegenerative DisordersReads 13 of these genesTFGAIMP1COQ7HYCC1PLP1BICD2About this report →
- Congenital MyopathiesReads 3 of these genesMYPNTPM2TPM3About this report →
- Pelizaeus-Merzbacher Disease & Hypomyelinating LeukodystrophiesReads 3 of these genesAIMP1HYCC1PLP1About this report →
- LipodystrophyReads 2 of these genesMFN2LMNAAbout this report →
- Limb-Girdle Muscular DystrophyReads 3 of these genesHMGCRANO5LMNAAbout this report →
- Spinal Muscular AtrophyReads 2 of these genesBICD2FBXO38About this report →
- Progressive Cardiac Conduction Disease & Sick Sinus SyndromeReads 1 of these genesLMNAAbout this report →
- Pyruvate Kinase Deficiency and Other Red Cell Enzyme DisordersReads 1 of these genesHK1About this report →
- Other Inherited LeukodystrophiesReads 3 of these genesAIMP1HYCC1PLP1About this report →
- HyperinsulinismReads 1 of these genesHK1About this report →
- Dilated CardiomyopathyReads 2 of these genesLMNAMYPNAbout this report →
- Myofibrillar MyopathiesReads 1 of these genesKYAbout this report →
- Lysosomal Storage DiseaseReads 2 of these genesLAMP2GNEAbout this report →
- Primary Mitochondrial DiseaseReads 3 of these genesMTRFRCOQ7FARS2About this report →
- Leigh SyndromeReads 2 of these genesMTRFRFARS2About this report →
- Hereditary Sensory and Autonomic Neuropathies (incl. Familial Dysautonomia)Reads 1 of these genesKIF1AAbout this report →
- Syndromic CraniosynostosisReads 1 of these genesKAT6AAbout this report →
- Intellectual DisabilityReads 3 of these genesKAT6AKIF1ANEXMIFAbout this report →
- Inherited ThrombocytopeniasReads 1 of these genesGNEAbout this report →
- Osteogenesis ImperfectaReads 1 of these genesANO5About this report →
- Hypertrophic CardiomyopathyReads 1 of these genesMYPNAbout this report →
- Retinitis PigmentosaReads 1 of these genesHK1About this report →
- Congenital Disorders of GlycosylationReads 1 of these genesGNEAbout this report →
- Epilepsy (Full Panel)Reads 1 of these genesNEXMIFAbout this report →
Read the genes linked to Lower limb amyotrophy, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome Test38 genes linked to Lower limb amyotrophy
Changes in these genes cause rare conditions in which Lower limb amyotrophy is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| HMGCR3-hydroxy-3-methylglutaryl-CoA reductase | Always | In 1 condition |
| INPP4Ainositol polyphosphate-4-phosphatase type I A | Always | In 1 condition |
| MFN2mitofusin 2 | Always | In 1 condition |
| MTRFRmitochondrial translation release factor in rescue | Always | In 1 condition |
| NEFHneurofilament heavy chain | Always | In 1 condition |
| PDXKpyridoxal kinase | Always | In 1 condition |
| TFGtrafficking from ER to golgi regulator | Always | In 1 condition |
| AIMP1aminoacyl tRNA synthetase complex interacting multifunctional protein 1 | Very often (80–99%) | In 1 condition |
| COQ7coenzyme Q7, hydroxylase | Very often (80–99%) | In 1 condition |
| HYCC1hyccin PI4KA lipid kinase complex subunit 1 | Very often (80–99%) | In 1 condition |
| KAT6Alysine acetyltransferase 6A | Very often (80–99%) | In 1 condition |
| MORC2MORC family CW-type zinc finger 2 | Very often (80–99%) | In 1 condition |
| PLP1proteolipid protein 1 | Very often (80–99%) | In 1 condition |
| ADSS1adenylosuccinate synthase 1 | Often (30–79%) | In 1 condition |
| ANO5anoctamin 5 | Often (30–79%) | In 1 condition |
| ARSIarylsulfatase family member I | Often (30–79%) | In 1 condition |
| ATAD3AATPase family AAA domain containing 3A | Often (30–79%) | In 1 condition |
| BICD2BICD cargo adaptor 2 | Often (30–79%) | In 1 condition |
| CYP7B1cytochrome P450 family 7 subfamily B member 1 | Often (30–79%) | In 2 conditions |
| FARS2phenylalanyl-tRNA synthetase 2, mitochondrial | Often (30–79%) | In 2 conditions |
| HK1hexokinase 1 | Often (30–79%) | In 1 condition |
| KIF1Akinesin family member 1A | Often (30–79%) | In 1 condition |
| KYkyphoscoliosis peptidase | Often (30–79%) | In 1 condition |
| LAMP2lysosome associated membrane protein 2 | Often (30–79%) | In 1 condition |
| NDRG1N-myc downstream regulated 1 | Often (30–79%) | In 1 condition |
| RTN2reticulon 2 | Often (30–79%) | In 1 condition |
| SLC33A1solute carrier family 33 member 1 | Often (30–79%) | In 1 condition |
| UBAP1ubiquitin associated protein 1 | Often (30–79%) | In 1 condition |
| VWA1von Willebrand factor A domain containing 1 | Often (30–79%) | In 1 condition |
| GNEglucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase | Sometimes (5–29%) | In 1 condition |
| LMNAlamin A/C | Sometimes (5–29%) | In 1 condition |
| MYPNmyopalladin | Sometimes (5–29%) | In 1 condition |
| NEFLneurofilament light chain | Sometimes (5–29%) | In 1 condition |
| NEXMIFneurite extension and migration factor | Sometimes (5–29%) | In 1 condition |
| TPM2tropomyosin 2 | Sometimes (5–29%) | In 1 condition |
| TPM3tropomyosin 3 | Sometimes (5–29%) | In 1 condition |
| FBXO38F-box protein 38 | Not recorded | In 1 condition |
| FITM2fat storage inducing transmembrane protein 2 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Narrower traits
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.19-9814e911.
AtlasWho We HelpOur ScienceProductsOutcomes
Log InAskSequence your genome↗
From traits to your genome
Read the genes behind these traits in your own DNA.
The Genome Test sequences nearly all of your DNA, not a preset panel, so every gene on these pages is in your data. Premium adds 810+ physician-ready reports.
From $449
Free shipping · Results in 6–8 weeks
