Trait
Decreased ability to exercise
Clinical name: Exercise intolerance
A functional motor deficit where individuals whose responses to the challenges of exercise fail to achieve levels considered normal for their age and gender.
Summary
- Also called
- Inability to exercise, Low exercise endurance, Poor exercise tolerance
- Body system
- Constitutional symptom
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read the genes linked to Decreased ability to exercise, and the rest of your genome, with one test.
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Get my Genome Test171 genes linked to Decreased ability to exercise
Changes in these genes cause rare conditions in which Decreased ability to exercise is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| ATP5F1DATP synthase F1 subunit delta | Always | In 2 conditions |
| COA3cytochrome c oxidase assembly factor 3 | Always | In 1 condition |
| COL13A1collagen type XIII alpha 1 chain | Always | In 1 condition |
| FARSAphenylalanyl-tRNA synthetase subunit alpha | Always | In 1 condition |
| FARSBphenylalanyl-tRNA synthetase subunit beta | Always | In 1 condition |
| FASTKD5FASTK mitochondrial RNA regulator 5 | Always | In 1 condition |
| GAAalpha glucosidase | Always | In 1 condition |
| GYS1glycogen synthase 1 | Always | In 2 conditions |
| HSPB8heat shock protein family B (small) member 8 | Always | In 1 condition |
| ISCUiron-sulfur cluster assembly enzyme | Always | In 1 condition |
| JPH1junctophilin 1 | Always | In 1 condition |
| MIEF2mitochondrial elongation factor 2 | Always | In 1 condition |
| MLIPmuscular LMNA interacting protein | Always | In 1 condition |
| MPV17mitochondrial inner membrane protein MPV17 | Always | In 1 condition |
| MSL2MSL complex subunit 2 | Always | In 1 condition |
| PACSIN3protein kinase C and casein kinase substrate in neurons 3 | Always | In 1 condition |
| PHKA1phosphorylase kinase regulatory subunit alpha 1 | Always | In 2 conditions |
| PIEZO2piezo type mechanosensitive ion channel component 2 | Always | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Always | In 5 conditions |
| POLG2DNA polymerase gamma 2, accessory subunit | Always | In 2 conditions |
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Always | In 1 condition |
| SLC18A3solute carrier family 18 member A3 | Always | In 1 condition |
| SLC25A4solute carrier family 25 member 4 | Always | In 3 conditions |
| TAFAZZINtafazzin, phospholipid-lysophospholipid transacylase | Always | In 2 conditions |
| TMEM126Btransmembrane protein 126B | Always | In 1 condition |
| TOP3ADNA topoisomerase III alpha | Always | In 2 conditions |
| TRMT5tRNA methyltransferase 5 | Always | In 1 condition |
| CCDC78coiled-coil domain containing 78 | Very often (80–99%) | In 1 condition |
| CPT2carnitine palmitoyltransferase 2 | Very often (80–99%) | In 2 conditions |
| DMDdystrophin | Very often (80–99%) | In 1 condition |
| ENO3enolase 3 | Very often (80–99%) | In 2 conditions |
| HADHAhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha | Very often (80–99%) | In 1 condition |
| HADHBhydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta | Very often (80–99%) | In 1 condition |
| PYGMglycogen phosphorylase, muscle associated | Very often (80–99%) | In 2 conditions |
| RNASEH1ribonuclease H1 | Very often (80–99%) | In 2 conditions |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Very often (80–99%) | In 4 conditions |
| ABCC9ATP binding cassette subfamily C member 9 | Often (30–79%) | In 1 condition |
| ACTA1actin alpha 1, skeletal muscle | Often (30–79%) | In 1 condition |
| ACTC1actin alpha cardiac muscle 1 | Often (30–79%) | In 1 condition |
| ALDH4A1aldehyde dehydrogenase 4 family member A1 | Often (30–79%) | In 1 condition |
Show 131 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| C1QBPcomplement C1q binding protein | Often (30–79%) | In 1 condition |
| CHCHD10coiled-coil-helix-coiled-coil-helix domain containing 10 | Often (30–79%) | In 2 conditions |
| CITED2Cbp/p300 interacting transactivator with ED-rich tail 2 | Often (30–79%) | In 2 conditions |
| COQ8Acoenzyme Q8A | Often (30–79%) | In 2 conditions |
| DTNAdystrobrevin alpha | Often (30–79%) | In 1 condition |
| ETFAelectron transfer flavoprotein subunit alpha | Often (30–79%) | In 1 condition |
| ETFBelectron transfer flavoprotein subunit beta | Often (30–79%) | In 1 condition |
| ETFDHelectron transfer flavoprotein dehydrogenase | Often (30–79%) | In 1 condition |
| GATA4GATA binding protein 4 | Often (30–79%) | In 2 conditions |
| GATA5GATA binding protein 5 | Often (30–79%) | In 1 condition |
| GATA6GATA binding protein 6 | Often (30–79%) | In 2 conditions |
| GJA5gap junction protein alpha 5 | Often (30–79%) | In 1 condition |
| GLAgalactosidase alpha | Often (30–79%) | In 1 condition |
| GMPPBGDP-mannose pyrophosphorylase B | Often (30–79%) | In 2 conditions |
| HINT1histidine triad nucleotide binding protein 1 | Often (30–79%) | In 1 condition |
| KBTBD13kelch repeat and BTB domain containing 13 | Often (30–79%) | In 2 conditions |
| KCNA5potassium voltage-gated channel subfamily A member 5 | Often (30–79%) | In 1 condition |
| KCNE1potassium voltage-gated channel subfamily E regulatory subunit 1 | Often (30–79%) | In 1 condition |
| KCNE2potassium voltage-gated channel subfamily E regulatory subunit 2 | Often (30–79%) | In 1 condition |
| KCNJ2potassium inwardly rectifying channel subfamily J member 2 | Often (30–79%) | In 1 condition |
| KCNJ3potassium inwardly rectifying channel subfamily J member 3 | Often (30–79%) | In 1 condition |
| KCNJ5potassium inwardly rectifying channel subfamily J member 5 | Often (30–79%) | In 1 condition |
| KCNQ1potassium voltage-gated channel subfamily Q member 1 | Often (30–79%) | In 1 condition |
| KLHL41kelch like family member 41 | Often (30–79%) | In 1 condition |
| MGME1mitochondrial genome maintenance exonuclease 1 | Often (30–79%) | In 2 conditions |
| MRPS2mitochondrial ribosomal protein S2 | Often (30–79%) | In 1 condition |
| MT-TEmitochondrially encoded tRNA-Glu (GAA/G) | Often (30–79%) | In 1 condition |
| MT-TKmitochondrially encoded tRNA-Lys (AAA/G) | Often (30–79%) | In 1 condition |
| MYH6myosin heavy chain 6 | Often (30–79%) | In 1 condition |
| MYL4myosin light chain 4 | Often (30–79%) | In 1 condition |
| MYPNmyopalladin | Often (30–79%) | In 1 condition |
| NEBnebulin | Often (30–79%) | In 1 condition |
| NKX2-5NK2 homeobox 5 | Often (30–79%) | In 2 conditions |
| NKX2-6NK2 homeobox 6 | Often (30–79%) | In 1 condition |
| NPPAnatriuretic peptide A | Often (30–79%) | In 1 condition |
| NUP155nucleoporin 155 | Often (30–79%) | In 1 condition |
| OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | Often (30–79%) | In 1 condition |
| PFKMphosphofructokinase, muscle | Often (30–79%) | In 1 condition |
| PGAM2phosphoglycerate mutase 2 | Often (30–79%) | In 2 conditions |
| PGM1phosphoglucomutase 1 | Often (30–79%) | In 1 condition |
| PHKG1phosphorylase kinase catalytic subunit gamma 1 | Often (30–79%) | In 1 condition |
| PITX2paired like homeodomain 2 | Often (30–79%) | In 1 condition |
| POLR2ARNA polymerase II subunit A | Often (30–79%) | In 1 condition |
| SCN1Bsodium voltage-gated channel beta subunit 1 | Often (30–79%) | In 1 condition |
| SCN2Bsodium voltage-gated channel beta subunit 2 | Often (30–79%) | In 1 condition |
| SCN3Bsodium voltage-gated channel beta subunit 3 | Often (30–79%) | In 1 condition |
| SCN4Bsodium voltage-gated channel beta subunit 4 | Often (30–79%) | In 1 condition |
| SCN5Asodium voltage-gated channel alpha subunit 5 | Often (30–79%) | In 1 condition |
| SLC4A1solute carrier family 4 member 1 (Diego blood group) | Often (30–79%) | In 1 condition |
| TBX20T-box transcription factor 20 | Often (30–79%) | In 1 condition |
| TLL1tolloid like 1 | Often (30–79%) | In 2 conditions |
| TPM2tropomyosin 2 | Often (30–79%) | In 1 condition |
| TPM3tropomyosin 3 | Often (30–79%) | In 1 condition |
| TTNtitin | Often (30–79%) | In 1 condition |
| TWNKtwinkle mtDNA helicase | Often (30–79%) | In 3 conditions |
| YARS2tyrosyl-tRNA synthetase 2 | Often (30–79%) | In 1 condition |
| ABCA3ATP binding cassette subfamily A member 3 | Sometimes (5–29%) | In 1 condition |
| ACAD9acyl-CoA dehydrogenase family member 9 | Sometimes (5–29%) | In 1 condition |
| ATP11AATPase phospholipid transporting 11A | Sometimes (5–29%) | In 1 condition |
| ATP5F1AATP synthase F1 subunit alpha | Sometimes (5–29%) | In 1 condition |
| ATP5F1EATP synthase F1 subunit epsilon | Sometimes (5–29%) | In 1 condition |
| ATP5MKATP synthase membrane subunit k | Sometimes (5–29%) | In 1 condition |
| ATP5POATP synthase peripheral stalk subunit OSCP | Sometimes (5–29%) | In 1 condition |
| ATPAF2ATP synthase mitochondrial F1 complex assembly factor 2 | Sometimes (5–29%) | In 1 condition |
| COL12A1collagen type XII alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| DOT1LDOT1 like histone lysine methyltransferase | Sometimes (5–29%) | In 1 condition |
| DPP9dipeptidyl peptidase 9 | Sometimes (5–29%) | In 1 condition |
| DSPdesmoplakin | Sometimes (5–29%) | In 1 condition |
| EPB41erythrocyte membrane protein band 4.1 | Sometimes (5–29%) | In 1 condition |
| FAM13Afamily with sequence similarity 13 member A | Sometimes (5–29%) | In 1 condition |
| GCDHglutaryl-CoA dehydrogenase | Sometimes (5–29%) | In 1 condition |
| GYPCglycophorin C (Gerbich blood group) | Sometimes (5–29%) | In 1 condition |
| HIVEP2HIVEP zinc finger 2 | Sometimes (5–29%) | In 1 condition |
| MT-ATP6mitochondrially encoded ATP synthase membrane subunit 6 | Sometimes (5–29%) | In 1 condition |
| MT-ATP8mitochondrially encoded ATP synthase membrane subunit 8 | Sometimes (5–29%) | In 2 conditions |
| MT-CO1mitochondrially encoded cytochrome c oxidase I | Sometimes (5–29%) | In 1 condition |
| MT-CO2mitochondrially encoded cytochrome c oxidase II | Sometimes (5–29%) | In 1 condition |
| MT-CO3mitochondrially encoded cytochrome c oxidase III | Sometimes (5–29%) | In 1 condition |
| MT-CYBmitochondrially encoded cytochrome b | Sometimes (5–29%) | In 1 condition |
| MT-ND1mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 | Sometimes (5–29%) | In 1 condition |
| MT-ND4mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4 | Sometimes (5–29%) | In 1 condition |
| MT-ND5mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5 | Sometimes (5–29%) | In 1 condition |
| MT-ND6mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6 | Sometimes (5–29%) | In 1 condition |
| MT-TFmitochondrially encoded tRNA-Phe (UUU/C) | Sometimes (5–29%) | In 1 condition |
| MT-THmitochondrially encoded tRNA-His (CAU/C) | Sometimes (5–29%) | In 1 condition |
| MT-TL1mitochondrially encoded tRNA-Leu (UUA/G) 1 | Sometimes (5–29%) | In 2 conditions |
| MT-TQmitochondrially encoded tRNA-Gln (CAA/G) | Sometimes (5–29%) | In 1 condition |
| MT-TS1mitochondrially encoded tRNA-Ser (UCN) 1 | Sometimes (5–29%) | In 2 conditions |
| MT-TS2mitochondrially encoded tRNA-Ser (AGU/C) 2 | Sometimes (5–29%) | In 1 condition |
| MT-TWmitochondrially encoded tRNA-Trp (UGA/G) | Sometimes (5–29%) | In 1 condition |
| MUC5Bmucin 5B, oligomeric mucus/gel-forming | Sometimes (5–29%) | In 1 condition |
| PARNpoly(A)-specific ribonuclease | Sometimes (5–29%) | In 1 condition |
| PHKA2phosphorylase kinase regulatory subunit alpha 2 | Sometimes (5–29%) | In 1 condition |
| PHKBphosphorylase kinase regulatory subunit beta | Sometimes (5–29%) | In 1 condition |
| PHKG2phosphorylase kinase catalytic subunit gamma 2 | Sometimes (5–29%) | In 1 condition |
| PTPMT1protein tyrosine phosphatase mitochondrial 1 | Sometimes (5–29%) | In 1 condition |
| RRM1ribonucleotide reductase catalytic subunit M1 | Sometimes (5–29%) | In 1 condition |
| RTEL1regulator of telomere elongation helicase 1 | Sometimes (5–29%) | In 1 condition |
| SFTPA1surfactant protein A1 | Sometimes (5–29%) | In 1 condition |
| SFTPA2surfactant protein A2 | Sometimes (5–29%) | In 1 condition |
| SFTPCsurfactant protein C | Sometimes (5–29%) | In 1 condition |
| SPTA1spectrin alpha, erythrocytic 1 | Sometimes (5–29%) | In 1 condition |
| SPTBspectrin beta, erythrocytic | Sometimes (5–29%) | In 1 condition |
| STN1STN1 subunit of CST complex | Sometimes (5–29%) | In 1 condition |
| TERCtelomerase RNA component | Sometimes (5–29%) | In 1 condition |
| TERTtelomerase reverse transcriptase | Sometimes (5–29%) | In 1 condition |
| TK2thymidine kinase 2 | Sometimes (5–29%) | In 1 condition |
| AGKacylglycerol kinase | Not recorded | In 1 condition |
| BCS1LBCS1 ubiquinol-cytochrome c reductase complex chaperone | Not recorded | In 1 condition |
| CAVIN1caveolae associated protein 1 | Not recorded | In 1 condition |
| COX10cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 | Not recorded | In 1 condition |
| COX15cytochrome c oxidase assembly factor COX15 | Not recorded | In 1 condition |
| COX6B1cytochrome c oxidase subunit 6B1 | Not recorded | In 1 condition |
| DNA2DNA replication helicase/nuclease 2 | Not recorded | In 1 condition |
| FASTKD2FASTK mitochondrial RNA regulator 2 | Not recorded | In 1 condition |
| FLAD1flavin adenine dinucleotide synthetase 1 | Not recorded | In 1 condition |
| LAMP2lysosome associated membrane protein 2 | Not recorded | In 1 condition |
| LDHAlactate dehydrogenase A | Not recorded | In 1 condition |
| MT-TNmitochondrially encoded tRNA-Asn (AAU/C) | Not recorded | In 1 condition |
| NDUFS4NADH:ubiquinone oxidoreductase subunit S4 | Not recorded | In 1 condition |
| PGK1phosphoglycerate kinase 1 | Not recorded | In 1 condition |
| PNPLA2patatin like domain 2, triacylglycerol lipase | Not recorded | In 1 condition |
| POPDC1popeye domain cAMP effector 1 | Not recorded | In 1 condition |
| RSPH4Aradial spoke head component 4A | Not recorded | In 1 condition |
| RSPH9radial spoke head component 9 | Not recorded | In 1 condition |
| SCO1synthesis of cytochrome C oxidase 1 | Not recorded | In 1 condition |
| SCO2synthesis of cytochrome C oxidase 2 | Not recorded | In 1 condition |
| SDHAsuccinate dehydrogenase complex flavoprotein subunit A | Not recorded | In 1 condition |
| SLC25A32solute carrier family 25 member 32 | Not recorded | In 1 condition |
| SURF1SURF1 cytochrome c oxidase assembly factor | Not recorded | In 1 condition |
| TACO1translational activator of cytochrome c oxidase I | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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