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Gene

TNNT1

troponin T1, slow skeletal type

Summary

Cytogenetic location
19q13.42
Coordinates
Chromosome 19: 55,132,698–55,149,206 (GRCh38)
Exons
14 exons across 16.5 kb
Protein
278 amino acids
Also known as
ANM, STNT, TNT, TNTS, FLJ98147, MGC104241, NEM5
MANE Select transcript
ENST00000588981.6NM_003283.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Congenital Myopathies

    • Nemaline myopathy

      A congenital myopathy defined by rod-shaped structures in muscle fibers, most often caused by NEB or ACTA1 variants.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong

How TNNT1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 19, with a bracket where TNNT1 sits. TNNT1 and 50 genes near it on chromosome 19, from 54,640,952 to 55,640,951.Chromosome 1919q13.42p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4354.8 Mb55 Mb55.2 Mb55.4 Mb55.6 MbLILRB4: 54,643,889–54,670,531, forward strandLILRB4KIR3DL3: 54,724,442–54,736,632, forward strandKIR3DL3KIR2DL3: 54,738,505–54,753,061, forward strandKIR2DL3KIR2DL1: 54,769,793–54,784,332, forward strandKIR2DL1KIR2DL4: 54,803,610–54,814,517, forward strandKIR2DL4KIR3DL1: 54,816,440–54,830,778, forward strandKIR3DL1KIR2DS4: 54,832,676–54,848,569, forward strandKIR2DS4KIR3DL2: 54,850,433–54,867,209, forward strandKIR3DL2FCAR: 54,874,227–54,891,420, forward strandFCARNCR1: 54,906,112–54,941,199, forward strandNCR1NLRP7: 54,923,454–54,966,312, reverse strandNLRP7NLRP2: 54,953,130–55,001,142, forward strandNLRP2GP6: 55,012,055–55,038,264, reverse strandGP6RDH13: 55,039,108–55,071,291, reverse strandRDH13EPS8L1: 55,072,020–55,090,124, forward strandEPS8L1PPP1R12C: 55,090,913–55,117,679, reverse strandPPP1R12CTNNT1: 55,132,698–55,149,206, reverse strandTNNT1TNNI3: 55,151,763–55,157,774, reverse strandTNNI3: 55,154,757–55,160,671, reverse strandDNAAF3: 55,158,661–55,166,722, reverse strandDNAAF3SYT5: 55,171,196–55,180,328, reverse strandPTPRH: 55,181,230–55,209,512, reverse strandPTPRHTMEM86B: 55,226,524–55,228,784, reverse strandTMEM86BPPP6R1: 55,229,776–55,259,070, reverse strandPPP6R1HSPBP1: 55,262,219–55,280,930, reverse strandHSPBP1BRSK1: 55,282,072–55,312,592, forward strandBRSK1TMEM150B: 55,309,440–55,334,048, reverse strandTMEM150BKMT5C: 55,339,367–55,348,122, forward strandKMT5CCOX6B2: 55,349,306–55,354,754, reverse strandCOX6B2: 55,352,301–55,359,516, reverse strandGARIN5B: 55,354,908–55,363,260, reverse strandIL11: 55,364,382–55,370,463, reverse strandTMEM190: 55,376,816–55,378,246, forward strandTMEM238: 55,379,244–55,384,305, reverse strandRPL28: 55,383,856–55,403,342, forward strandUBE2S: 55,385,311–55,408,164, reverse strandUBE2SSHISA7: 55,428,740–55,452,900, reverse strandSHISA7ISOC2: 55,452,975–55,462,343, reverse strandISOC2C19orf85: 55,463,001–55,464,752, reverse strandC19orf85ZNF628: 55,476,597–55,484,487, forward strandZNF628NAT14: 55,484,949–55,487,578, forward strandSSC5D: 55,488,404–55,519,099, forward strandSBK2: 55,528,607–55,537,143, reverse strandSBK2SBK3: 55,539,018–55,550,284, reverse strandSBK3ZNF579: 55,576,774–55,580,921, reverse strandZNF579FIZ1: 55,591,371–55,606,194, reverse strandFIZ1ZNF524: 55,599,714–55,603,592, forward strandZNF524ZNF865: 55,605,502–55,617,269, forward strandZNF865ZNF784: 55,620,741–55,624,570, reverse strandZNF581: 55,624,664–55,647,294, forward strandZNF580: 55,635,003–55,643,470, forward strandDiagram of TNNT1: 14 exons on the reverse strand of chromosome 19Exon 12: 3 known disease-causing sitesExon 11: 4 known disease-causing sitesExon 10: 3 known disease-causing sitesExon 9: 1 known disease-causing siteExon 8: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 5: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 2: 2 known disease-causing sitesExon 14: 55,132,698–55,132,960, 263 basesExon 13: 55,133,887–55,133,927, 41 basesExon 12: 55,134,066–55,134,204, 139 basesExon 11: 55,137,103–55,137,212, 110 basesExon 10: 55,137,961–55,138,074, 114 basesExon 9: 55,140,883–55,140,960, 78 basesExon 8: 55,141,186–55,141,302, 117 basesExon 7: 55,141,857–55,141,920, 64 basesExon 6: 55,145,544–55,145,565, 22 basesExon 5: 55,146,434–55,146,466, 33 basesExon 4: 55,146,681–55,146,707, 27 basesExon 3: 55,147,008–55,147,021, 14 basesExon 2: 55,147,126–55,147,168, 43 basesExon 1: 55,149,161–55,149,206, 46 bases141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.1 kb of the gene's 16.5 kb; 837 of those bases code for the protein.

How a genome test reads TNNT1

27

positions in TNNT1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 16.5 kb of TNNT1, introns included, not only the 1.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TNNT1 gene: troponin T1, slow skeletal type. Retrieved 16 October 2026, from https://dantelabs.com/genes/tnnt1

Vancouver

Dante Labs. TNNT1 gene: troponin T1, slow skeletal type [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tnnt1

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