Trait
Tired easily
Clinical name: Easy fatigability
Increased susceptibility to fatigue.
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test98 genes linked to Tired easily
Changes in these genes cause rare conditions in which Tired easily is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CHRNA1cholinergic receptor nicotinic alpha 1 subunit | Always | In 1 condition |
| CHRNB1cholinergic receptor nicotinic beta 1 subunit | Always | In 1 condition |
| CHRNDcholinergic receptor nicotinic delta subunit | Always | In 2 conditions |
| CWF19L1CWF19 like cell cycle control factor 1 | Always | In 1 condition |
| FEM1Bfem-1 homolog B | Always | In 1 condition |
| ISCUiron-sulfur cluster assembly enzyme | Always | In 1 condition |
| KCNK3potassium two pore domain channel subfamily K member 3 | Always | In 1 condition |
| MBTPS1membrane bound transcription factor peptidase, site 1 | Always | In 1 condition |
| MUSKmuscle associated receptor tyrosine kinase | Always | In 2 conditions |
| PACSIN3protein kinase C and casein kinase substrate in neurons 3 | Always | In 1 condition |
| PFKMphosphofructokinase, muscle | Always | In 1 condition |
| PPP2R5Cprotein phosphatase 2 regulatory subunit B'gamma | Always | In 1 condition |
| RAPSNreceptor associated protein of the synapse | Always | In 1 condition |
| SCN4Asodium voltage-gated channel alpha subunit 4 | Always | In 1 condition |
| SLC25A1solute carrier family 25 member 1 | Always | In 1 condition |
| SLC25A4solute carrier family 25 member 4 | Always | In 2 conditions |
| SLC25A42solute carrier family 25 member 42 | Always | In 1 condition |
| TRU-TCA1-1tRNA-SeC (anticodon TCA) 1-1 | Always | In 1 condition |
| ACTA1actin alpha 1, skeletal muscle | Often (30–79%) | In 1 condition |
| AIPAHR interacting HSP90 co-chaperone | Often (30–79%) | In 1 condition |
| BAG3BAG cochaperone 3 | Often (30–79%) | In 1 condition |
| CCN6cellular communication network factor 6 | Often (30–79%) | In 1 condition |
| CDH23cadherin related 23 | Often (30–79%) | In 2 conditions |
| CHST11carbohydrate sulfotransferase 11 | Often (30–79%) | In 1 condition |
| DCCDCC netrin 1 receptor | Often (30–79%) | In 1 condition |
| DNAL4dynein axonemal light chain 4 | Often (30–79%) | In 1 condition |
| FKBP14FKBP prolyl isomerase 14 | Often (30–79%) | In 1 condition |
| HACD13-hydroxyacyl-CoA dehydratase 1 | Often (30–79%) | In 1 condition |
| HSPB3heat shock protein family B (small) member 3 | Often (30–79%) | In 1 condition |
| ITGA7integrin subunit alpha 7 | Often (30–79%) | In 1 condition |
| LDHAlactate dehydrogenase A | Often (30–79%) | In 1 condition |
| LIG3DNA ligase 3 | Often (30–79%) | In 1 condition |
| MAP3K20mitogen-activated protein kinase kinase kinase 20 | Often (30–79%) | In 2 conditions |
| MEN1menin 1 | Often (30–79%) | In 1 condition |
| MGME1mitochondrial genome maintenance exonuclease 1 | Often (30–79%) | In 2 conditions |
| MYL2myosin light chain 2 | Often (30–79%) | In 1 condition |
| NARS2asparaginyl-tRNA synthetase 2, mitochondrial | Often (30–79%) | In 1 condition |
| NTN1netrin 1 | Often (30–79%) | In 1 condition |
| PNPLA2patatin like domain 2, triacylglycerol lipase | Often (30–79%) | In 2 conditions |
| POLGDNA polymerase gamma, catalytic subunit | Often (30–79%) | In 2 conditions |
Show 58 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| PRKAR1Aprotein kinase cAMP-dependent type I regulatory subunit alpha | Often (30–79%) | In 1 condition |
| RAD51RAD51 recombinase | Often (30–79%) | In 1 condition |
| RRM2Bribonucleotide reductase regulatory TP53 inducible subunit M2B | Often (30–79%) | In 2 conditions |
| RYR1ryanodine receptor 1 | Often (30–79%) | In 2 conditions |
| SDHAsuccinate dehydrogenase complex flavoprotein subunit A | Often (30–79%) | In 1 condition |
| SDHAF1succinate dehydrogenase complex assembly factor 1 | Often (30–79%) | In 1 condition |
| SDHBsuccinate dehydrogenase complex iron sulfur subunit B | Often (30–79%) | In 1 condition |
| SDHDsuccinate dehydrogenase complex subunit D | Often (30–79%) | In 1 condition |
| SELENONselenoprotein N | Often (30–79%) | In 1 condition |
| SLC18A3solute carrier family 18 member A3 | Often (30–79%) | In 1 condition |
| SYT2synaptotagmin 2 | Often (30–79%) | In 2 conditions |
| TGFB1transforming growth factor beta 1 | Often (30–79%) | In 1 condition |
| TPM2tropomyosin 2 | Often (30–79%) | In 2 conditions |
| TPM3tropomyosin 3 | Often (30–79%) | In 2 conditions |
| TYMPthymidine phosphorylase | Often (30–79%) | In 1 condition |
| ALG14ALG14 UDP-N-acetylglucosaminyltransferase subunit | Sometimes (5–29%) | In 1 condition |
| ALG2ALG2 alpha-1,3/1,6-mannosyltransferase | Sometimes (5–29%) | In 1 condition |
| CALRcalreticulin | Sometimes (5–29%) | In 1 condition |
| CMPK2cytidine/uridine monophosphate kinase 2 | Sometimes (5–29%) | In 1 condition |
| COL13A1collagen type XIII alpha 1 chain | Sometimes (5–29%) | In 1 condition |
| COLQcollagen like tail subunit of asymmetric acetylcholinesterase | Sometimes (5–29%) | In 2 conditions |
| DPAGT1dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 | Sometimes (5–29%) | In 1 condition |
| GFPT1glutamine--fructose-6-phosphate transaminase 1 | Sometimes (5–29%) | In 3 conditions |
| GMPPBGDP-mannose pyrophosphorylase B | Sometimes (5–29%) | In 2 conditions |
| GTPBP3GTP binding protein 3, mitochondrial | Sometimes (5–29%) | In 1 condition |
| HNRNPKheterogeneous nuclear ribonucleoprotein K | Sometimes (5–29%) | In 2 conditions |
| JAK2Janus kinase 2 | Sometimes (5–29%) | In 1 condition |
| JAM2junctional adhesion molecule 2 | Sometimes (5–29%) | In 1 condition |
| KICS2KICSTOR subunit 2 | Sometimes (5–29%) | In 1 condition |
| LAMB2laminin subunit beta 2 | Sometimes (5–29%) | In 1 condition |
| MICU1mitochondrial calcium uptake 1 | Sometimes (5–29%) | In 1 condition |
| MPLMPL proto-oncogene, thrombopoietin receptor | Sometimes (5–29%) | In 1 condition |
| MYORGmyogenesis regulating glycosidase | Sometimes (5–29%) | In 1 condition |
| MYPNmyopalladin | Sometimes (5–29%) | In 1 condition |
| NAA60N-alpha-acetyltransferase 60, NatF catalytic subunit | Sometimes (5–29%) | In 1 condition |
| NEBnebulin | Sometimes (5–29%) | In 1 condition |
| NFE2L2NFE2 like bZIP transcription factor 2 | Sometimes (5–29%) | In 1 condition |
| PDGFBplatelet derived growth factor subunit B | Sometimes (5–29%) | In 1 condition |
| PDGFRBplatelet derived growth factor receptor beta | Sometimes (5–29%) | In 1 condition |
| POLG2DNA polymerase gamma 2, accessory subunit | Sometimes (5–29%) | In 1 condition |
| POMT1protein O-mannosyltransferase 1 | Sometimes (5–29%) | In 2 conditions |
| RRP12ribosomal RNA processing 12 homolog | Sometimes (5–29%) | In 1 condition |
| SLC20A2solute carrier family 20 member 2 | Sometimes (5–29%) | In 1 condition |
| TET2tet methylcytosine dioxygenase 2 | Sometimes (5–29%) | In 1 condition |
| TWNKtwinkle mtDNA helicase | Sometimes (5–29%) | In 1 condition |
| XPR1xenotropic and polytropic retrovirus receptor 1 | Sometimes (5–29%) | In 1 condition |
| AGKacylglycerol kinase | Not recorded | In 1 condition |
| AGRNagrin | Not recorded | In 1 condition |
| CASQ1calsequestrin 1 | Not recorded | In 1 condition |
| CHRNEcholinergic receptor nicotinic epsilon subunit | Not recorded | In 3 conditions |
| DNM2dynamin 2 | Not recorded | In 1 condition |
| DOK7docking protein 7 | Not recorded | In 1 condition |
| MTMR14myotubularin related protein 14 | Not recorded | In 1 condition |
| PYROXD1pyridine nucleotide-disulphide oxidoreductase domain 1 | Not recorded | In 1 condition |
| STIM1stromal interaction molecule 1 | Not recorded | In 1 condition |
| SURF1SURF1 cytochrome c oxidase assembly factor | Not recorded | In 1 condition |
| TDP2tyrosyl-DNA phosphodiesterase 2 | Not recorded | In 1 condition |
| TMEM126Btransmembrane protein 126B | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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