Trait
Muscle stiffness
A condition in which muscles cannot be moved quickly without accompanying pain or spasm.
Summary
- Body system
- Abnormality of the musculoskeletal system
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test63 genes linked to Muscle stiffness
Changes in these genes cause rare conditions in which Muscle stiffness is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| GLRBglycine receptor beta | Always | In 2 conditions |
| HSPG2heparan sulfate proteoglycan 2 | Always | In 1 condition |
| KPNA3karyopherin subunit alpha 3 | Always | In 1 condition |
| SCN4Asodium voltage-gated channel alpha subunit 4 | Always | In 4 conditions |
| ARXaristaless related homeobox | Very often (80–99%) | In 1 condition |
| ATAD1ATPase family AAA domain containing 1 | Very often (80–99%) | In 1 condition |
| CLCN1chloride voltage-gated channel 1 | Very often (80–99%) | In 3 conditions |
| DHCR2424-dehydrocholesterol reductase | Very often (80–99%) | In 1 condition |
| GLRA1glycine receptor alpha 1 | Very often (80–99%) | In 1 condition |
| GPHNgephyrin | Very often (80–99%) | In 1 condition |
| RNU4ATACRNA, U4atac small nuclear | Very often (80–99%) | In 1 condition |
| SLC6A5solute carrier family 6 member 5 | Very often (80–99%) | In 2 conditions |
| ACTA1actin alpha 1, skeletal muscle | Often (30–79%) | In 1 condition |
| ANO5anoctamin 5 | Often (30–79%) | In 1 condition |
| CACNA1Scalcium voltage-gated channel subunit alpha1 S | Often (30–79%) | In 2 conditions |
| CAVIN1caveolae associated protein 1 | Often (30–79%) | In 1 condition |
| CNBPCCHC-type zinc finger nucleic acid binding protein | Often (30–79%) | In 1 condition |
| FGFR1fibroblast growth factor receptor 1 | Often (30–79%) | In 1 condition |
| GABRA3gamma-aminobutyric acid type A receptor subunit alpha3 | Often (30–79%) | In 1 condition |
| KAT6Alysine acetyltransferase 6A | Often (30–79%) | In 1 condition |
| KBTBD13kelch repeat and BTB domain containing 13 | Often (30–79%) | In 2 conditions |
| KCNA1potassium voltage-gated channel subfamily A member 1 | Often (30–79%) | In 1 condition |
| KCNJ18potassium inwardly rectifying channel subfamily J member 18 | Often (30–79%) | In 1 condition |
| KLHL41kelch like family member 41 | Often (30–79%) | In 1 condition |
| KRASKRas proto-oncogene, GTPase | Often (30–79%) | In 1 condition |
| MYOTmyotilin | Often (30–79%) | In 2 conditions |
| MYPNmyopalladin | Often (30–79%) | In 1 condition |
| NEBnebulin | Often (30–79%) | In 1 condition |
| PANK2pantothenate kinase 2 | Often (30–79%) | In 1 condition |
| PRKAR1Bprotein kinase cAMP-dependent type I regulatory subunit beta | Often (30–79%) | In 1 condition |
| REEP2receptor accessory protein 2 | Often (30–79%) | In 1 condition |
| RYR1ryanodine receptor 1 | Often (30–79%) | In 2 conditions |
| SIL1SIL1 nucleotide exchange factor | Often (30–79%) | In 1 condition |
| SLC2A1solute carrier family 2 member 1 | Often (30–79%) | In 1 condition |
| SPG7SPG7 matrix AAA peptidase subunit, paraplegin | Often (30–79%) | In 1 condition |
| TPM2tropomyosin 2 | Often (30–79%) | In 1 condition |
| TPM3tropomyosin 3 | Often (30–79%) | In 1 condition |
| ADARadenosine deaminase RNA specific | Sometimes (5–29%) | In 1 condition |
| AOPEPaminopeptidase O (putative) | Sometimes (5–29%) | In 1 condition |
| CRYABcrystallin alpha B | Sometimes (5–29%) | In 1 condition |
Show 23 more genes
| Gene | How often it is seen | Conditions |
|---|---|---|
| GALCgalactosylceramidase | Sometimes (5–29%) | In 1 condition |
| HINT1histidine triad nucleotide binding protein 1 | Sometimes (5–29%) | In 2 conditions |
| IFIH1interferon induced with helicase C domain 1 | Sometimes (5–29%) | In 1 condition |
| KIF11kinesin family member 11 | Sometimes (5–29%) | In 1 condition |
| LSM11LSM11, U7 small nuclear RNA associated | Sometimes (5–29%) | In 1 condition |
| MYO5Amyosin VA | Sometimes (5–29%) | In 1 condition |
| POLGDNA polymerase gamma, catalytic subunit | Sometimes (5–29%) | In 1 condition |
| PSAPprosaposin | Sometimes (5–29%) | In 1 condition |
| RNASEH2Aribonuclease H2 subunit A | Sometimes (5–29%) | In 1 condition |
| RNASEH2Bribonuclease H2 subunit B | Sometimes (5–29%) | In 1 condition |
| RNASEH2Cribonuclease H2 subunit C | Sometimes (5–29%) | In 1 condition |
| RNU7-1RNA, U7 small nuclear 1 | Sometimes (5–29%) | In 1 condition |
| RRM1ribonucleotide reductase catalytic subunit M1 | Sometimes (5–29%) | In 1 condition |
| SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 | Sometimes (5–29%) | In 1 condition |
| TK2thymidine kinase 2 | Sometimes (5–29%) | In 1 condition |
| TOP3ADNA topoisomerase III alpha | Sometimes (5–29%) | In 1 condition |
| TREX1three prime repair exonuclease 1 | Sometimes (5–29%) | In 1 condition |
| ACADVLacyl-CoA dehydrogenase very long chain | Not recorded | In 1 condition |
| CPT2carnitine palmitoyltransferase 2 | Not recorded | In 1 condition |
| DYSFdysferlin | Not recorded | In 1 condition |
| LDHAlactate dehydrogenase A | Not recorded | In 1 condition |
| STIM1stromal interaction molecule 1 | Not recorded | In 1 condition |
| TNFRSF1ATNF receptor superfamily member 1A | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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