Trait
Hand clenching
An abnormal hand posture in which the hands are clenched to fists. All digits held completely flexed at the metacarpophalangeal and interphalangeal joints. In prenatal sonography of the fetal clenched hand, the index finger overlaps a clenched fist formed by the other digits. The proximal interphalangeal articulation of the index finger is flexed and ulnarly deviated, and the thumb is adducted.
Summary
- Also called
- Clenched hands, Clenched hand, Fisted hand, Fisting, Hands fisted, Hands tightly fisted, Thumb clasp
- Body system
- Abnormality of limbs
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test36 genes linked to Hand clenching
Changes in these genes cause rare conditions in which Hand clenching is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| CDK5cyclin dependent kinase 5 | Always | In 1 condition |
| DSTdystonin | Always | In 3 conditions |
| GTPBP2GTP binding protein 2 | Always | In 1 condition |
| MOGSmannosyl-oligosaccharide glucosidase | Always | In 1 condition |
| SCYL2SCY1 like pseudokinase 2 | Always | In 1 condition |
| THOC2THO complex subunit 2 | Always | In 1 condition |
| TOR1Atorsin family 1 member A | Always | In 1 condition |
| WWOXWW domain containing oxidoreductase | Always | In 1 condition |
| L1CAML1 cell adhesion molecule | Very often (80–99%) | In 1 condition |
| NR4A2nuclear receptor subfamily 4 group A member 2 | Very often (80–99%) | In 1 condition |
| SMG9SMG9 nonsense mediated mRNA decay factor | Very often (80–99%) | In 1 condition |
| TBR1T-box brain transcription factor 1 | Very often (80–99%) | In 1 condition |
| ASXL3ASXL transcriptional regulator 3 | Often (30–79%) | In 1 condition |
| BICD2BICD cargo adaptor 2 | Often (30–79%) | In 1 condition |
| GALCgalactosylceramidase | Often (30–79%) | In 1 condition |
| KIDINS220kinase D interacting substrate 220 | Often (30–79%) | In 1 condition |
| MAPTmicrotubule associated protein tau | Often (30–79%) | In 1 condition |
| MYOD1myogenic differentiation 1 | Often (30–79%) | In 1 condition |
| PSAPprosaposin | Often (30–79%) | In 1 condition |
| SNAPINSNAP associated protein | Often (30–79%) | In 1 condition |
| BCORBCL6 corepressor | Sometimes (5–29%) | In 1 condition |
| COG8component of oligomeric golgi complex 8 | Sometimes (5–29%) | In 1 condition |
| FLNBfilamin B | Sometimes (5–29%) | In 1 condition |
| GNB1G protein subunit beta 1 | Sometimes (5–29%) | In 1 condition |
| GRIK2glutamate ionotropic receptor kainate type subunit 2 | Sometimes (5–29%) | In 1 condition |
| HNRNPH1heterogeneous nuclear ribonucleoprotein H1 | Sometimes (5–29%) | In 1 condition |
| KCNA1potassium voltage-gated channel subfamily A member 1 | Sometimes (5–29%) | In 1 condition |
| SYNE1spectrin repeat containing nuclear envelope protein 1 | Sometimes (5–29%) | In 1 condition |
| ATP6V1E1ATPase H+ transporting V1 subunit E1 | Not recorded | In 1 condition |
| BLTP1bridge-like lipid transfer protein family member 1 | Not recorded | In 1 condition |
| CNTNAP1contactin associated protein 1 | Not recorded | In 1 condition |
| GLE1GLE1 RNA export mediator | Not recorded | In 1 condition |
| NEBnebulin | Not recorded | In 1 condition |
| SLC6A9solute carrier family 6 member 9 | Not recorded | In 1 condition |
| TPM2tropomyosin 2 | Not recorded | In 1 condition |
| WDR73WD repeat domain 73 | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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