Reference genomeGRCh38hg38
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Read the genes linked to Reduced systolic function, and the rest of your genome, with one test.
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Get my Genome Test15 genes linked to Reduced systolic function
Changes in these genes cause rare conditions in which Reduced systolic function is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| JPH2junctophilin 2 | Always | In 1 condition |
| NEXNnexilin F-actin binding protein | Always | In 1 condition |
| CASQ2calsequestrin 2 | Often (30–79%) | In 1 condition |
| DESdesmin | Often (30–79%) | In 1 condition |
| RYR2ryanodine receptor 2 | Often (30–79%) | In 1 condition |
| TRDNtriadin | Often (30–79%) | In 1 condition |
| MYPNmyopalladin | Sometimes (5–29%) | In 1 condition |
| SOX17SRY-box transcription factor 17 | Sometimes (5–29%) | In 1 condition |
| TKFCtriokinase and FMN cyclase | Sometimes (5–29%) | In 1 condition |
| TPM2tropomyosin 2 | Sometimes (5–29%) | In 1 condition |
| TPM3tropomyosin 3 | Sometimes (5–29%) | In 1 condition |
| LIMS2LIM zinc finger domain containing 2 | Not recorded | In 1 condition |
| PLNphospholamban | Not recorded | In 1 condition |
| SCN5Asodium voltage-gated channel alpha subunit 5 | Not recorded | In 1 condition |
| SGCDsarcoglycan delta | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
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Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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