Gene
PTPN6
protein tyrosine phosphatase non-receptor type 6
- HGNC 9658(opens in a new tab)
- Ensembl gene ENSG00000111679(opens in a new tab)
- NCBI Gene 5777(opens in a new tab)
Summary
- Cytogenetic location
- 12p13.31
- Coordinates
- Chromosome 12: 6,951,356–6,961,316 (GRCh38)
- Exons
- 16 exons across 10 kb
- Protein
- 595 amino acids
- Also known as
- HCP, HCPH, PTP-1C, SHP-1, SHP1
- MANE Select transcript
- ENST00000318974.14NM_002831.6
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
Read PTPN6, and the rest of your genome, with one test.
From $449Free shipping · Results in 6–8 weeks
Get my Genome TestCurated reports relevant to this gene
No Genome Test report reads PTPN6 yet. The test sequences your whole genome, so your data includes it all the same.
How PTPN6 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 2.2 kb of the gene's 10 kb; 1,788 of those bases code for the protein.
Traits linked to PTPN6
The Human Phenotype Ontology lists these as features of the rare conditions PTPN6 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the immune system
- Abnormal circulating interleukin concentration
- Predominantly dermal neutrophilic infiltrate
- Abnormality of tumor necrosis factor secretion
- Acne
- Increased circulating interleukin 6 concentration
- Muscle inflammation
- Sterile abscess
- Acne inversa
Show 3 more traits
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
Cite this page
Dante Labs. (n.d.). PTPN6 gene: protein tyrosine phosphatase non-receptor type 6. Retrieved 17 October 2026, from https://dantelabs.com/genes/ptpn6
Dante Labs. PTPN6 gene: protein tyrosine phosphatase non-receptor type 6 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ptpn6
One test. A lifetime of answers.
From $449Free shipping · Results in 6–8 weeks