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Gene

TNFRSF11B

TNF receptor superfamily member 11b

Summary

Cytogenetic location
8q24.12
Coordinates
Chromosome 8: 118,923,557–118,951,885 (GRCh38)
Exons
5 exons across 28.3 kb
Protein
401 amino acids
Inheritance
Autosomal recessive
Also known as
OCIF, TR1
Previous symbols
OPG
MANE Select transcript
ENST00000297350.9NM_002546.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Familial Paget Disease of Bone

    • Juvenile Paget diseaseAutosomal recessive

      A rare childhood-onset bone disorder caused by TNFRSF11B variants, with rapid bone turnover, bone pain, fractures and deformity.

      • 2 GenCC submitters rate it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How TNFRSF11B is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 8, with a bracket where TNFRSF11B sits. TNFRSF11B and 4 genes near it on chromosome 8, from 118,437,721 to 119,437,720.Chromosome 88q24.12p23.3p23.2p23.1p22p21.3p21.2p21.1p12p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.3q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.3118.6 Mb118.8 Mb119 Mb119.2 Mb119.4 MbSAMD12: 118,189,455–118,622,112, reverse strandSAMD12TNFRSF11B: 118,923,557–118,951,885, reverse strandTNFRSF11BCOLEC10: 118,995,452–119,113,619, forward strandCOLEC10MAL2: 119,165,034–119,249,903, forward strandMAL2CCN3: 119,416,368–119,424,453, forward strandCCN3Diagram of TNFRSF11B: 5 exons on the reverse strand of chromosome 8Exon 5: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 2: 1 known disease-causing siteExon 5: 118,923,557–118,924,762, 1,206 basesExon 4: 118,926,494–118,926,718, 225 basesExon 3: 118,928,738–118,928,929, 192 basesExon 2: 118,932,931–118,933,300, 370 basesExon 1: 118,951,792–118,951,885, 94 bases543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.1 kb of the gene's 28.3 kb; 1,206 of those bases code for the protein.

How a genome test reads TNFRSF11B

3

positions in TNFRSF11B where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 28.3 kb of TNFRSF11B, introns included, not only the 2.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TNFRSF11B gene: TNF receptor superfamily member 11b. Retrieved 17 October 2026, from https://dantelabs.com/genes/tnfrsf11b

Vancouver

Dante Labs. TNFRSF11B gene: TNF receptor superfamily member 11b [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tnfrsf11b

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