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Gene

HLA-DQB1

major histocompatibility complex, class II, DQ beta 1

Summary

Cytogenetic location
6p21.32
Coordinates
Chromosome 6: 32,659,467–32,666,657 (GRCh38)
Exons
5 exons across 7.2 kb
Protein
261 amino acids
Also known as
IDDM1, CELIAC1
Previous symbols
HLA-DQB
MANE Select transcript
ENST00000434651.7NM_002123.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads HLA-DQB1 yet. The test sequences your whole genome, so your data includes it all the same.

How HLA-DQB1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 6, with a bracket where HLA-DQB1 sits. HLA-DQB1 and 31 genes near it on chromosome 6, from 32,163,062 to 33,163,061.Chromosome 66p21.32p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2732.2 Mb32.4 Mb32.6 Mb32.8 Mb33 MbPPT2: 32,146,580–32,163,679, forward strandPPT2-EGFL8: 32,153,845–32,171,978, forward strandEGFL8: 32,163,918–32,171,980, forward strandAGPAT1: 32,167,118–32,178,112, reverse strandRNF5: 32,178,391–32,184,769, forward strandAGER: 32,180,963–32,184,365, reverse strandAGERPBX2: 32,184,733–32,190,278, reverse strandPBX2GPSM3: 32,190,766–32,195,523, reverse strandGPSM3NOTCH4: 32,194,843–32,224,111, reverse strandNOTCH4TSBP1: 32,288,526–32,371,907, reverse strandTSBP1BTNL2: 32,391,481–32,407,181, reverse strandBTNL2HLA-DRA: 32,439,870–32,445,181, forward strandHLA-DRAHLA-DRB5: 32,516,622–32,530,369, reverse strandHLA-DRB5HLA-DRB1: 32,577,902–32,589,848, reverse strandHLA-DRB1HLA-DQA1: 32,628,179–32,659,533, forward strandHLA-DQA1HLA-DQB1: 32,659,467–32,666,657, reverse strandHLA-DQB1HLA-DQA2: 32,741,391–32,747,198, forward strandHLA-DQA2HLA-DQB2: 32,756,094–32,763,563, reverse strandHLA-DQB2HLA-DOB: 32,812,763–32,820,466, reverse strandHLA-DOB: 32,813,767–32,838,822, reverse strandTAP2: 32,821,833–32,838,802, reverse strandTAP2PSMB8: 32,840,717–32,844,679, reverse strandPSMB8PSMB9: 32,844,136–32,882,881, forward strandTAP1: 32,845,204–32,854,026, reverse strandHLA-DMB: 32,929,338–32,941,490, reverse strandHLA-DMB: 32,937,364–32,953,122, reverse strandHLA-DMA: 32,948,613–32,969,094, reverse strandHLA-DMABRD2: 32,968,564–32,981,505, forward strandBRD2HLA-DOA: 33,004,178–33,009,617, reverse strandHLA-DOAHLA-DPA1: 33,064,569–33,080,781, reverse strandHLA-DPA1HLA-DPB1: 33,073,786–33,091,655, forward strandHLA-DPB1COL11A2: 33,162,681–33,192,802, reverse strandCOL11A2Diagram of HLA-DQB1: 5 exons on the reverse strand of chromosome 6Exon 5: 32,659,467–32,660,249, 783 basesExon 4: 32,661,347–32,661,457, 111 basesExon 3: 32,661,967–32,662,248, 282 basesExon 2: 32,664,798–32,665,067, 270 basesExon 1: 32,666,499–32,666,657, 159 bases543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.6 kb of the gene's 7.2 kb; 786 of those bases code for the protein.

Traits linked to HLA-DQB1

The Human Phenotype Ontology lists these as features of the rare conditions HLA-DQB1 can cause. Each trait's page lists the other genes linked to it.

Abnormality of the nervous system

Show 32 more traits

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.

Cite this page

APA

Dante Labs. (n.d.). HLA-DQB1 gene: major histocompatibility complex, class II, DQ beta 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/hla-dqb1

Vancouver

Dante Labs. HLA-DQB1 gene: major histocompatibility complex, class II, DQ beta 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/hla-dqb1

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