Skip to content
Use your HSA or FSA funds

Gene

ANTXR2

ANTXR cell adhesion molecule 2

Summary

Cytogenetic location
4q21.21
Coordinates
Chromosome 4: 79,901,146–80,073,229 (GRCh38)
Exons
17 exons across 172.1 kb
Protein
488 amino acids
Inheritance
Autosomal recessive
Also known as
CMG2, CMG-2, FLJ31074
MANE Select transcript
ENST00000403729.7NM_058172.6
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Hereditary Fibromatoses

    • Hyaline fibromatosis syndromeAutosomal recessive

      Skin nodules, gum overgrowth, painful joint contractures and, in severe forms, protein-losing diarrhoea, caused by variants in ANTXR2.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How ANTXR2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 4, with a bracket where ANTXR2 sits. ANTXR2 and 3 genes near it on chromosome 4, from 79,487,188 to 80,487,187.Chromosome 44q21.21p16.3p16.2p16.1p15.33p15.32p15.31p15.2p15.1p14p13p12p11q11q12q13.1q13.2q13.3q21.1q21.21q21.22q21.23q21.3q22.1q22.2q22.3q23q24q25q26q27q28.1q28.2q28.3q31.1q31.21q31.22q31.23q31.3q32.1q32.2q32.3q33q34.1q34.2q34.3q35.1q35.279.6 Mb79.8 Mb80 Mb80.2 Mb80.4 MbANTXR2: 79,901,146–80,073,229, reverse strandANTXR2PRDM8: 80,183,879–80,260,318, forward strandPRDM8FGF5: 80,266,639–80,336,680, forward strandFGF5CFAP299: 80,335,730–80,963,750, forward strandCFAP299Diagram of ANTXR2: 17 exons on the reverse strand of chromosome 4Exon 15: 3 known disease-causing sitesExon 14: 2 known disease-causing sitesExon 13: 3 known disease-causing sitesExon 12: 1 known disease-causing siteExon 9: 2 known disease-causing sitesExon 8: 2 known disease-causing sitesExon 3: 2 known disease-causing sitesExon 2: 1 known disease-causing siteExon 1: 2 known disease-causing sitesExon 17: 79,901,146–79,907,467, 6,322 basesExon 16: 79,977,621–79,977,701, 81 basesExon 15: 79,978,007–79,978,174, 168 basesExon 14: 79,983,878–79,983,970, 93 basesExon 13: 79,984,819–79,984,863, 45 basesExon 12: 80,008,521–80,008,616, 96 basesExon 11: 80,018,898–80,018,976, 79 basesExon 10: 80,031,623–80,031,692, 70 basesExon 9: 80,033,472–80,033,570, 99 basesExon 8: 80,035,972–80,036,032, 61 basesExon 7: 80,054,272–80,054,352, 81 basesExon 6: 80,055,150–80,055,218, 69 basesExon 5: 80,055,360–80,055,467, 108 basesExon 4: 80,055,932–80,056,013, 82 basesExon 3: 80,069,436–80,069,507, 72 basesExon 2: 80,071,583–80,071,654, 72 basesExon 1: 80,072,409–80,073,229, 821 bases171510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 8.4 kb of the gene's 172.1 kb; 1,467 of those bases code for the protein.

How a genome test reads ANTXR2

26

positions in ANTXR2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 172.1 kb of ANTXR2, introns included, not only the 8.4 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ANTXR2 gene: ANTXR cell adhesion molecule 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/antxr2

Vancouver

Dante Labs. ANTXR2 gene: ANTXR cell adhesion molecule 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/antxr2

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test