Skip to content
Use your HSA or FSA funds

Gene

TNXB

tenascin XB

Summary

Cytogenetic location
6p21.33-p21.32
Coordinates
Chromosome 6: 32,041,153–32,109,338 (GRCh38)
Exons
44 exons across 68.2 kb
Protein
4,244 amino acids
Also known as
TNXBS, XBS, XB, HXBL, TN-X, TNX
Previous symbols
TNXB1, TNXB2
MANE Select transcript
ENST00000644971.2NM_001365276.2
Locus type
gene with protein product

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

How TNXB is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 6, with a bracket where TNXB sits. TNXB and 64 genes near it on chromosome 6, from 31,575,246 to 32,575,245.Chromosome 66p21.33-p21.32p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2731.6 Mb31.8 Mb32 Mb32.2 Mb32.4 MbTNF: 31,575,558–31,578,336, forward strandLTB: 31,580,525–31,582,522, reverse strandLST1: 31,581,065–31,588,911, forward strandLST1NCR3: 31,588,895–31,593,217, reverse strandNCR3AIF1: 31,615,214–31,617,025, forward strandAIF1PRRC2A: 31,620,675–31,637,771, forward strandPRRC2A: 31,622,774–31,622,860, forward strand: 31,623,874–31,625,499, forward strandBAG6: 31,638,543–31,652,747, reverse strandAPOM: 31,652,416–31,658,214, forward strandC6orf47: 31,658,298–31,660,778, reverse strandGPANK1: 31,661,228–31,666,283, reverse strandCSNK2B: 31,665,227–31,670,343, forward strand: 31,666,102–31,673,546, forward strandLY6G5B: 31,669,976–31,673,776, forward strandLY6G5C: 31,676,684–31,684,040, reverse strandLY6G5CABHD16A: 31,686,954–31,703,391, reverse strandLY6G6F: 31,706,863–31,710,801, forward strandLY6G6F-LY6G6D: 31,706,904–31,717,918, forward strandLY6G6D: 31,715,285–31,717,919, forward strandLY6G6DMPIG6B: 31,718,594–31,726,714, forward strandLY6G6C: 31,718,648–31,721,746, reverse strandDDAH2: 31,726,586–31,730,617, reverse strandCLIC1: 31,730,579–31,740,558, reverse strandMSH5: 31,739,677–31,762,678, forward strandMSH5MSH5-SAPCD1: 31,740,020–31,764,851, forward strandSAPCD1: 31,762,656–31,764,851, forward strandVWA7: 31,765,590–31,777,328, reverse strandVWA7VARS1: 31,777,518–31,795,975, reverse strandLSM2: 31,797,019–31,806,992, reverse strandLSM2HSPA1L: 31,809,619–31,815,788, reverse strandHSPA1A: 31,815,543–31,817,994, forward strandHSPA1AHSPA1B: 31,827,738–31,830,254, forward strandHSPA1BNEU1: 31,857,063–31,862,905, reverse strandNEU1SLC44A4: 31,863,173–31,879,198, reverse strandSLC44A4EHMT2: 31,879,758–31,897,723, reverse strandEHMT2C2: 31,897,785–31,945,677, forward strandC2ZBTB12: 31,899,065–31,902,103, reverse strandZBTB12: 31,927,698–31,952,048, forward strandCFB: 31,945,650–31,952,086, forward strandNELFE: 31,952,087–31,959,079, reverse strandSKIC2: 31,959,025–31,969,852, forward strandSKIC2DXO: 31,969,810–31,972,517, reverse strandDXOWHR1: 31,971,091–31,982,821, forward strandWHR1C4A: 31,981,991–32,005,247, forward strandC4AC4B: 32,014,725–32,035,975, forward strandC4BCYP21A2: 32,038,297–32,042,321, forward strandCYP21A2TNXB: 32,041,153–32,109,338, reverse strandTNXBATF6B: 32,115,264–32,128,255, reverse strandATF6BFKBPL: 32,128,697–32,131,070, reverse strandFKBPLPPT2: 32,146,580–32,163,679, forward strandPRRT1: 32,147,292–32,153,083, reverse strandPRRT1: 32,150,495–32,154,373, reverse strandPPT2-EGFL8: 32,153,845–32,171,978, forward strandEGFL8: 32,163,918–32,171,980, forward strandAGPAT1: 32,167,118–32,178,112, reverse strandRNF5: 32,178,391–32,184,769, forward strandAGER: 32,180,963–32,184,365, reverse strandPBX2: 32,184,733–32,190,278, reverse strandGPSM3: 32,190,766–32,195,523, reverse strandNOTCH4: 32,194,843–32,224,111, reverse strandNOTCH4TSBP1: 32,288,526–32,371,907, reverse strandTSBP1BTNL2: 32,391,481–32,407,181, reverse strandBTNL2HLA-DRA: 32,439,870–32,445,181, forward strandHLA-DRAHLA-DRB5: 32,516,622–32,530,369, reverse strandHLA-DRB5Diagram of TNXB: 44 exons on the reverse strand of chromosome 6Exon 43: 1 known disease-causing siteExon 42: 1 known disease-causing siteExon 41: 1 known disease-causing siteExon 40: 1 known disease-causing siteExon 36: 1 known disease-causing siteExon 35: 1 known disease-causing siteExon 33: 1 known disease-causing siteExon 32: 3 known disease-causing sitesExon 31: 11 known disease-causing sitesExon 30: 6 known disease-causing sitesExon 29: 10 known disease-causing sitesExon 28: 9 known disease-causing sitesExon 27: 4 known disease-causing sitesExon 26: 9 known disease-causing sitesExon 25: 6 known disease-causing sitesExon 24: 11 known disease-causing sitesExon 23: 12 known disease-causing sitesExon 22: 2 known disease-causing sitesExon 21: 1 known disease-causing siteExon 20: 4 known disease-causing sitesExon 19: 6 known disease-causing sitesExon 18: 8 known disease-causing sitesExon 17: 4 known disease-causing sitesExon 16: 6 known disease-causing sitesExon 15: 5 known disease-causing sitesExon 14: 5 known disease-causing sitesExon 13: 10 known disease-causing sitesExon 12: 4 known disease-causing sitesExon 11: 8 known disease-causing sitesExon 10: 11 known disease-causing sitesExon 9: 6 known disease-causing sitesExon 8: 11 known disease-causing sitesExon 7: 8 known disease-causing sitesExon 6: 5 known disease-causing sitesExon 5: 7 known disease-causing sitesExon 4: 2 known disease-causing sitesExon 3: 50 known disease-causing sitesExon 2: 6 known disease-causing sitesExon 44: 32,041,153–32,041,450, 298 basesExon 43: 32,041,771–32,041,934, 164 basesExon 42: 32,042,012–32,042,173, 162 basesExon 41: 32,042,266–32,042,362, 97 basesExon 40: 32,042,455–32,042,606, 152 basesExon 39: 32,042,699–32,042,831, 133 basesExon 38: 32,042,951–32,043,081, 131 basesExon 37: 32,043,175–32,043,318, 144 basesExon 36: 32,043,437–32,043,556, 120 basesExon 35: 32,043,749–32,043,892, 144 basesExon 34: 32,044,007–32,044,129, 123 basesExon 33: 32,044,381–32,044,716, 336 basesExon 32: 32,045,006–32,045,326, 321 basesExon 31: 32,046,175–32,046,456, 282 basesExon 30: 32,047,734–32,048,012, 279 basesExon 29: 32,048,363–32,048,650, 288 basesExon 28: 32,049,270–32,049,587, 318 basesExon 27: 32,049,998–32,050,321, 324 basesExon 26: 32,052,670–32,052,993, 324 basesExon 25: 32,053,388–32,053,711, 324 basesExon 24: 32,055,851–32,056,174, 324 basesExon 23: 32,056,586–32,056,903, 318 basesExon 22: 32,058,058–32,058,390, 333 basesExon 21: 32,061,397–32,061,720, 324 basesExon 20: 32,062,157–32,062,483, 327 basesExon 19: 32,064,821–32,065,117, 297 basesExon 18: 32,067,661–32,067,984, 324 basesExon 17: 32,068,390–32,068,707, 318 basesExon 16: 32,068,822–32,069,136, 315 basesExon 15: 32,069,553–32,069,861, 309 basesExon 14: 32,070,127–32,070,414, 288 basesExon 13: 32,071,990–32,072,298, 309 basesExon 12: 32,073,647–32,073,952, 306 basesExon 11: 32,079,033–32,079,365, 333 basesExon 10: 32,081,368–32,081,673, 306 basesExon 9: 32,082,036–32,082,326, 291 basesExon 8: 32,084,413–32,084,709, 297 basesExon 7: 32,085,750–32,086,118, 369 basesExon 6: 32,088,785–32,089,048, 264 basesExon 5: 32,089,223–32,089,379, 157 basesExon 4: 32,095,076–32,095,191, 116 basesExon 3: 32,095,611–32,097,449, 1,839 basesExon 2: 32,097,796–32,098,206, 411 basesExon 1: 32,109,181–32,109,338, 158 bases442515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 13.1 kb of the gene's 68.2 kb; 12,735 of those bases code for the protein.

How a genome test reads TNXB

273

positions in TNXB where ClinVar classes a change as pathogenic or likely pathogenic

273 of them (100%) fall in regions short reads find hard.

  • Low mappability (51 sites)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
  • MHC (273 sites)The major histocompatibility complex (HLA genes), highly polymorphic and poorly represented by a single reference.
  • Segmental duplications (71 sites)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 68.2 kb of TNXB, introns included, not only the 13.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TNXB gene: tenascin XB. Retrieved 17 October 2026, from https://dantelabs.com/genes/tnxb

Vancouver

Dante Labs. TNXB gene: tenascin XB [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/tnxb

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test