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Gene

LBR

lamin B receptor

Summary

Cytogenetic location
1q42.12
Coordinates
Chromosome 1: 225,401,502–225,428,038 (GRCh38)
Exons
14 exons across 26.5 kb
Protein
615 amino acids
Also known as
DHCR14B, TDRD18
MANE Select transcript
ENST00000272163.9NM_002296.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads LBR yet. The test sequences your whole genome, so your data includes it all the same.

How LBR is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where LBR sits. LBR and 7 genes near it on chromosome 1, from 224,914,770 to 225,914,769.Chromosome 11q42.12p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44225 Mb225.2 Mb225.4 Mb225.6 Mb225.8 MbDNAH14: 224,896,262–225,399,292, forward strandDNAH14LBR: 225,401,502–225,428,038, reverse strandLBRENAH: 225,486,765–225,653,334, reverse strandENAHSRP9: 225,777,699–225,790,670, forward strandSRP9EPHX1: 225,810,048–225,845,567, forward strandEPHX1TMEM63A: 225,845,532–225,884,122, reverse strandTMEM63ALEFTY1: 225,886,279–225,911,382, reverse strandLEFTY1: 225,886,696–225,924,278, reverse strandDiagram of LBR: 14 exons on the reverse strand of chromosome 1Exon 14: 2 known disease-causing sitesExon 13: 2 known disease-causing sitesExon 12: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 6: 1 known disease-causing siteExon 3: 2 known disease-causing sitesExon 14: 225,401,502–225,403,463, 1,962 basesExon 13: 225,404,404–225,404,526, 123 basesExon 12: 225,404,626–225,404,706, 81 basesExon 11: 225,406,664–225,406,832, 169 basesExon 10: 225,410,291–225,410,416, 126 basesExon 9: 225,411,337–225,411,440, 104 basesExon 8: 225,412,454–225,412,645, 192 basesExon 7: 225,415,278–225,415,332, 55 basesExon 6: 225,417,984–225,418,180, 197 basesExon 5: 225,419,263–225,419,452, 190 basesExon 4: 225,419,715–225,419,798, 84 basesExon 3: 225,422,077–225,422,277, 201 basesExon 2: 225,423,911–225,424,089, 179 basesExon 1: 225,427,954–225,428,038, 85 bases141210864215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.7 kb of the gene's 26.5 kb; 1,848 of those bases code for the protein.

How a genome test reads LBR

9

positions in LBR where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 26.5 kb of LBR, introns included, not only the 3.7 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). LBR gene: lamin B receptor. Retrieved 17 October 2026, from https://dantelabs.com/genes/lbr

Vancouver

Dante Labs. LBR gene: lamin B receptor [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/lbr

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