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Gene

IL36RN

interleukin 36 receptor antagonist

Summary

Cytogenetic location
2q14.1
Coordinates
Chromosome 2: 113,059,198–113,064,744 (GRCh38)
Exons
5 exons across 5.5 kb
Protein
155 amino acids
Inheritance
Autosomal recessive
Also known as
FIL1, FIL1(DELTA), FIL1D, IL1HY1, IL1RP3, IL1L1, IL-1F5, IL36RA, MGC29840
Previous symbols
IL1F5
MANE Select transcript
ENST00000393200.7NM_012275.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Rare Monogenic Autoinflammatory Diseases

    • Generalised pustular psoriasis (DITRA)Autosomal recessive

      Episodes of widespread sterile pustules with fever, caused by IL36RN deficiency.

      • 2 GenCC submitters rate it definitive or strong

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How IL36RN is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 2, with a bracket where IL36RN sits. IL36RN and 17 genes near it on chromosome 2, from 112,561,971 to 113,561,970.Chromosome 22q14.1p25.3p25.2p25.1p24.3p24.2p24.1p23.3p23.2p23.1p22.3p22.2p22.1p21p16.3p16.2p16.1p15p14p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13q14.1q14.2q14.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.1q32.2q32.3q33.1q33.2q33.3q34q35q36.1q36.2q36.3q37.1q37.2q37.3112.6 Mb112.8 Mb113 Mb113.2 Mb113.4 MbPOLR1B: 112,541,915–112,579,818, forward strandPOLR1BCHCHD5: 112,584,240–112,589,275, forward strandCHCHD5SLC20A1: 112,645,853–112,664,727, forward strandSLC20A1NT5DC4: 112,721,020–112,742,879, forward strandNT5DC4CKAP2L: 112,736,349–112,764,664, reverse strandCKAP2LIL1A: 112,773,916–112,784,500, reverse strandIL1AIL1B: 112,829,750–112,864,235, reverse strandIL1BIL37: 112,911,160–112,918,882, forward strandIL37IL36G: 112,973,203–112,985,672, forward strandIL36GIL36A: 113,005,459–113,008,044, forward strandIL36AIL36B: 113,022,089–113,052,867, reverse strandIL36BIL36RN: 113,059,198–113,064,744, forward strandIL36RNIL38: 113,067,970–113,075,843, forward strandIL38IL1RN: 113,099,315–113,134,016, forward strandIL1RNPSD4: 113,157,325–113,209,396, forward strandPSD4PAX8: 113,215,997–113,279,001, reverse strandPAX8ZNG1B: 113,437,691–113,496,204, forward strandZNG1BFOXD4L1: 113,498,665–113,501,150, forward strandFOXD4L1Diagram of IL36RN: 5 exons on the forward strand of chromosome 2Exon 2: 1 known disease-causing siteExon 3: 2 known disease-causing sitesExon 4: 3 known disease-causing sitesExon 5: 5 known disease-causing sitesExon 1: 113,059,198–113,059,241, 44 basesExon 2: 113,059,412–113,059,467, 56 basesExon 3: 113,060,852–113,060,937, 86 basesExon 4: 113,062,124–113,062,251, 128 basesExon 5: 113,062,453–113,064,744, 2,292 bases123455′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.6 kb of the gene's 5.5 kb; 468 of those bases code for the protein.

How a genome test reads IL36RN

15

positions in IL36RN where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 5.5 kb of IL36RN, introns included, not only the 2.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). IL36RN gene: interleukin 36 receptor antagonist. Retrieved 17 October 2026, from https://dantelabs.com/genes/il36rn

Vancouver

Dante Labs. IL36RN gene: interleukin 36 receptor antagonist [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/il36rn

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