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Gene

COL10A1

collagen type X alpha 1 chain

Summary

Cytogenetic location
6q22.1
Coordinates
Chromosome 6: 116,118,909–116,126,132 (GRCh38)
Exons
3 exons across 7.2 kb
Protein
680 amino acids
MANE Select transcript
ENST00000651968.1NM_000493.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads COL10A1 yet. The test sequences your whole genome, so your data includes it all the same.

How COL10A1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 6, with a bracket where COL10A1 sits. COL10A1 and 12 genes near it on chromosome 6, from 115,622,521 to 116,622,520.Chromosome 66q22.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q27115.8 Mb116 Mb116.2 Mb116.4 Mb116.6 MbFRK: 115,931,149–116,061,093, reverse strandFRKNT5DC1: 116,100,804–116,249,497, forward strandNT5DC1COL10A1: 116,118,909–116,126,132, reverse strandCOL10A1TSPYL4: 116,249,964–116,254,075, reverse strandTSPYL4DSE: 116,253,604–116,444,861, forward strandDSETSPYL1: 116,267,760–116,279,930, reverse strandTSPYL1: 116,399,395–116,463,696, forward strandCALHM6: 116,461,365–116,466,082, forward strandCALHM6TRAPPC3L: 116,494,989–116,545,684, reverse strandTRAPPC3LCALHM5: 116,511,604–116,524,788, forward strandCALHM5CALHM4: 116,529,013–116,561,127, forward strandCALHM4RWDD1: 116,571,386–116,598,204, forward strandRWDD1RSPH4A: 116,616,474–116,634,765, forward strandRSPH4ADiagram of COL10A1: 3 exons on the reverse strand of chromosome 6Exon 3: 20 known disease-causing sitesExon 2: 1 known disease-causing siteExon 3: 116,118,909–116,121,961, 3,053 basesExon 2: 116,125,339–116,125,507, 169 basesExon 1: 116,126,053–116,126,132, 80 bases3215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.3 kb of the gene's 7.2 kb; 2,043 of those bases code for the protein.

How a genome test reads COL10A1

21

positions in COL10A1 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 7.2 kb of COL10A1, introns included, not only the 3.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). COL10A1 gene: collagen type X alpha 1 chain. Retrieved 17 October 2026, from https://dantelabs.com/genes/col10a1

Vancouver

Dante Labs. COL10A1 gene: collagen type X alpha 1 chain [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/col10a1

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