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Gene

LYN

LYN proto-oncogene, Src family tyrosine kinase

Summary

Cytogenetic location
8q12.1
Coordinates
Chromosome 8: 55,879,835–56,014,169 (GRCh38)
Exons
13 exons across 134.3 kb
Protein
512 amino acids
Inheritance
Autosomal dominant
Also known as
JTK8
MANE Select transcript
ENST00000519728.6NM_002350.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Rare Monogenic Autoinflammatory Diseases

    • LYN-related autoinflammatory disease with vasculitisAutosomal dominant

      Neonatal-onset fevers, rash, blood vessel inflammation and liver involvement caused by LYN gain-of-function variants.

      • 2 GenCC submitters rate it definitive or strong

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How LYN is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 8, with a bracket where LYN sits. LYN and 9 genes near it on chromosome 8, from 55,447,002 to 56,447,001.Chromosome 88q12.1p23.3p23.2p23.1p22p21.3p21.2p21.1p12p11.23p11.22p11.21p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.3q21.11q21.12q21.13q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.355.6 Mb55.8 Mb56 Mb56.2 Mb56.4 MbXKR4: 55,102,028–55,542,054, forward strandXKR4TMEM68: 55,696,424–55,773,417, reverse strandTMEM68TGS1: 55,773,065–55,827,247, forward strandTGS1LYN: 55,879,835–56,014,169, forward strandLYNRPS20: 56,020,034–56,074,575, reverse strandRPS20MOS: 56,112,942–56,113,982, reverse strandMOSPLAG1: 56,160,909–56,211,357, reverse strandPLAG1CHCHD7: 56,211,560–56,218,809, forward strandCHCHD7SDR16C5: 56,300,005–56,320,776, reverse strandSDR16C5PENK: 56,436,674–56,448,048, reverse strandPENKDiagram of LYN: 13 exons on the forward strand of chromosome 8Exon 1: 55,879,835–55,880,103, 269 basesExon 2: 55,941,855–55,941,991, 137 basesExon 3: 55,946,448–55,946,493, 46 basesExon 4: 55,947,618–55,947,723, 106 basesExon 5: 55,950,459–55,950,557, 99 basesExon 6: 55,950,681–55,950,784, 104 basesExon 7: 55,951,966–55,952,115, 150 basesExon 8: 55,953,832–55,953,984, 153 basesExon 9: 55,966,715–55,966,897, 183 basesExon 10: 55,969,717–55,969,793, 77 basesExon 11: 55,998,346–55,998,499, 154 basesExon 12: 55,999,418–55,999,549, 132 basesExon 13: 56,009,908–56,014,169, 4,262 bases124681012135′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 5.9 kb of the gene's 134.3 kb; 1,539 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). LYN gene: LYN proto-oncogene, Src family tyrosine kinase. Retrieved 16 October 2026, from https://dantelabs.com/genes/lyn

Vancouver

Dante Labs. LYN gene: LYN proto-oncogene, Src family tyrosine kinase [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/lyn

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