Skip to content
Use your HSA or FSA funds

Gene

TYROBP

transmembrane immune signaling adaptor TYROBP

Summary

Cytogenetic location
19q13.12
Coordinates
Chromosome 19: 35,904,403–35,908,295 (GRCh38)
Exons
5 exons across 3.9 kb
Protein
113 amino acids
Inheritance
Autosomal recessive
Also known as
DAP12, PLO-SL, KARAP
Previous symbols
PLOSL
MANE Select transcript
ENST00000262629.9NM_003332.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Adult-Onset Leukodystrophies (CSF1R, LMNB1, Nasu-Hakola)

    • Nasu-Hakola disease (polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy)Autosomal recessive

      Changes in TYROBP or TREM2 cause bone cysts and fractures in young adulthood, followed by progressive changes in personality and memory.

      • 3 GenCC submitters rate it definitive or strong

Broader groupings

  • Other Inherited Leukodystrophies

    • Leukodystrophy (other and unspecified types)

      One of 80 genes linked to it

      Inherited conditions that damage or prevent the normal formation of myelin, the white matter of the brain and spinal cord. Different types follow autosomal recessive, autosomal dominant or X-linked inheritance depending on the gene involved.

      • 3 GenCC submitters rate it definitive or strong
      What knowing changes

      Knowing the specific genetic cause can end a diagnostic search, guide supportive care and surveillance, show whether a specific treatment exists, and allow testing of relatives.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How TYROBP is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 19, with a bracket where TYROBP sits. TYROBP and 46 genes near it on chromosome 19, from 35,406,349 to 36,406,348.Chromosome 1919q13.12p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4335.6 Mb35.8 Mb36 Mb36.2 Mb36.4 MbFFAR2: 35,443,907–35,451,767, forward strandFFAR2KRTDAP: 35,487,324–35,495,558, reverse strandDMKN: 35,497,220–35,513,704, reverse strandDMKNSBSN: 35,523,367–35,528,351, reverse strandSBSNGAPDHS: 35,533,455–35,545,319, forward strandGAPDHSTMEM147: 35,545,600–35,547,527, forward strandTMEM147ATP4A: 35,549,339–35,563,658, reverse strandATP4APMIS2: 35,586,161–35,587,296, forward strandPMIS2HAUS5: 35,612,735–35,625,355, forward strandHAUS5RBM42: 35,628,989–35,638,927, forward strandRBM42ETV2: 35,641,730–35,644,871, forward strandETV2COX6B1: 35,648,230–35,662,890, forward strandCOX6B1UPK1A: 35,666,516–35,678,481, forward strandUPK1AZBTB32: 35,704,558–35,717,048, forward strandKMT2B: 35,717,973–35,738,880, forward strandIGFLR1: 35,738,798–35,742,459, reverse strand: 35,739,252–35,745,432, reverse strandU2AF1L4: 35,742,464–35,745,460, reverse strandPSENEN: 35,745,070–35,747,519, forward strand: 35,745,678–35,754,519, forward strandLIN37: 35,748,361–35,754,519, forward strandHSPB6: 35,754,566–35,758,079, reverse strandHSPB6PROSER3: 35,758,143–35,771,398, forward strandPROSER3ARHGAP33: 35,774,532–35,788,822, forward strandARHGAP33PRODH2: 35,799,975–35,813,299, reverse strandPRODH2NPHS1: 35,825,372–35,869,287, reverse strandNPHS1KIRREL2: 35,851,369–35,867,145, forward strandAPLP1: 35,867,899–35,879,803, forward strandAPLP1NFKBID: 35,887,129–35,902,303, reverse strandNFKBIDHCST: 35,899,017–35,904,377, forward strandHCSTTYROBP: 35,904,403–35,908,295, reverse strandTYROBPLRFN3: 35,935,358–35,946,624, forward strandLRFN3SDHAF1: 35,995,188–35,996,312, forward strandSDHAF1SYNE4: 36,000,545–36,008,831, reverse strandSYNE4ALKBH6: 36,009,113–36,014,297, reverse strandALKBH6CLIP3: 36,014,660–36,033,343, reverse strandCLIP3THAP8: 36,033,393–36,054,739, reverse strandWDR62: 36,054,649–36,105,112, forward strandWDR62OVOL3: 36,111,116–36,113,711, forward strandOVOL3POLR2I: 36,111,817–36,115,213, reverse strandPOLR2ITBCB: 36,114,289–36,125,948, forward strandTBCBCAPNS1: 36,139,953–36,150,356, forward strandCAPNS1COX7A1: 36,150,287–36,152,699, reverse strandZNF565: 36,181,542–36,246,257, reverse strandZNF565ZNF146: 36,214,602–36,239,969, forward strandZNF146ZFP14: 36,334,453–36,379,208, reverse strandZFP14ZFP82: 36,383,120–36,418,924, reverse strandZFP82Diagram of TYROBP: 5 exons on the reverse strand of chromosome 19Exon 3: 2 known disease-causing sitesExon 5: 35,904,403–35,904,634, 232 basesExon 4: 35,907,218–35,907,264, 47 basesExon 3: 35,907,446–35,907,580, 135 basesExon 2: 35,907,730–35,907,762, 33 basesExon 1: 35,908,168–35,908,295, 128 bases543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 0.6 kb of the gene's 3.9 kb; 342 of those bases code for the protein.

How a genome test reads TYROBP

2

positions in TYROBP where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 3.9 kb of TYROBP, introns included, not only the 0.6 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). TYROBP gene: transmembrane immune signaling adaptor TYROBP. Retrieved 16 October 2026, from https://dantelabs.com/genes/tyrobp

Vancouver

Dante Labs. TYROBP gene: transmembrane immune signaling adaptor TYROBP [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/tyrobp

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test