Gene
CCN6
cellular communication network factor 6
- HGNC 12771↗(opens in a new tab)
- Ensembl gene ENSG00000112761↗(opens in a new tab)
- NCBI Gene 8838↗(opens in a new tab)
Summary
- Cytogenetic location
- 6q21
- Coordinates
- Chromosome 6: 112,054,104–112,069,686 (GRCh38)
- Exons
- 5 exons across 15.6 kb
- Protein
- 354 amino acids
- Also known as
- WISP-3
- Previous symbols
- WISP3
- MANE Select transcript
- ENST00000368666.7NM_198239.2
- Locus type
- gene with protein product
- Very high
- Confident
- Low
- Very low
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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No Genome Test report reads CCN6 yet. The test sequences your whole genome, so your data includes it all the same.
How CCN6 is laid out
- Coding sequence
- Untranslated region
- Intron
- Direction of transcription
- Known disease-causing sites
Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.
Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).
Nearby genes from Ensembl release 116, on GRCh38.
Exons make up 1.4 kb of the gene's 15.6 kb; 1,065 of those bases code for the protein.
How a genome test reads CCN6
29
positions in CCN6 where ClinVar classes a change as pathogenic or likely pathogenic
None of them falls in a region short reads find hard.
A whole genome covers all 15.6 kb of CCN6, introns included, not only the 1.4 kb of exons.
Traits linked to CCN6
The Human Phenotype Ontology lists these as features of the rare conditions CCN6 can cause. Each trait's page lists the other genes linked to it.
Abnormality of the musculoskeletal system
- Flattened vertebrae
- Irregular vertebral endplates
- Polyarticular arthropathy
- Spondyloepiphyseal dysplasia
- Hyperconvex vertebral body endplates
- Infancy onset short-trunk short stature
- Irregularity of vertebral bodies
- Limitation of joint mobility
Show 21 more traits
- Muscle weakness
- Permanent flexion of the finger or toe
- Scoliosis
- Thoracolumbar kyphoscoliosis
- Tired easily
- Wedge-shaped vertebrae
- Abnormal ilium morphology
- Abnormality of the shoulder
- Beaking of vertebral bodies
- Generalized osteoporosis
- Large end part of bone
- Periarticular calcification
- Prominent swayback
- Degenerative joint disease
- Disease of the joints
- Flat end part of bone
- Joint stiffness
- Kyphoscoliosis
- Limited neck movement
- Osteoporosis
- Sclerotic vertebral endplates
Abnormality of limbs
- Narrow small joints of the hand
- Abnormality of hand joint mobility
- Abnormality of the elbow
- Abnormality of the hip joint
- Abnormality of the knee
- Joint contracture of the hand
- Wrist swelling
- Broad femoral neck
Show 12 more traits
- Coxa vara
- Enlarged end part of innermost thighbone
- Enlarged hinge joints
- Flat end part of innermost thighbone
- Irregular acetabular roof
- Knock knees
- Outward bow-leggedness
- Short neck of thighbone
- Abnormal feet structure
- Broad wide portion of long bone
- Enlarged metacarpophalangeal joints
- Permanent flexion of the finger
External links
Gene records
Transcript
Protein
Where this comes from
- HGNC: the gene's symbol, name, other symbols and location.
- MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
- ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
- The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
Cite this page
Dante Labs. (n.d.). CCN6 gene: cellular communication network factor 6. Retrieved 17 October 2026, from https://dantelabs.com/genes/ccn6
Dante Labs. CCN6 gene: cellular communication network factor 6 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/ccn6
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